ISSN 1674-3865  CN 21-1569/R
主管：国家卫生和计划生育委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
Chinese Pediatrics of Integrated Traditional and Western Medicine

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (3): 185-190.

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Meta-analysis of the treatment for Kawasaki disease with Weiqi and Yingxue differentiation

Objective: To conduct a Meta-analysis of the efficacy of Weiqi Yingxue differentiation in the treatment of Kawasaki disease.#br# Methods: Through computer and manual retrieval of keywords,search related literatures by logging into major database websites at home and abroad,and collect the literatures of randomized controlled clinical studies on the treatment of Kawasaki disease with Weiqi Yingxue differentiation published at home and abroad from 2005 to 2019.Through quality evaluation,supplementary and re-screening were conducted according to the inclusion criteria of literature.Intervention measures were Weiqi Yingxue differentiation treatment and conventional western medicine treatment.RevMan 5-3 software was used to make a meta-analysis of the included literatures that met the standards.It mainly included significantly effective rate,effective rate,heterogeneity and publication bias.#br# Results: A total of 195 relevant literatures were retrieved,and a total of 701 children with Kawasaki disease in 10 literatures were finally included.The significant effective and effective heterogeneity were:χ2=6.09,P=0.73;χ2=2.61,P=0.98.The results showed that there was no heterogeneity.When using Weiqi Yingxue differentiation combined with gamma globulin and pure gamma globulin to treat Kawasaki disease,the significant effective rate combined with OR=1.97,95% CI (1.44,2.68),overall effect test Z=4.29 (P<0.000 1).The effective rate was combined with OR=3.92,95% CI (2.24,6.86),and the overall effect test Z=4.77 (P<0.000 01).The difference was statistically significant.Meta-analysis showed that the total significantly effective rate and total effective rate of Weiqi Yingxue differentiation in the treatment of Kawasaki disease were significantly better than those of western medicine alone (P<0.05).#br# Conclusion: The total significantly effective rate and total effective rate of Weiqi Yingxue differentiation combined with gamma globulin in the treatment of Kawasaki disease are significantly higher than those of gamma globulin alone,which has certain advantages in improving the clinical efficacy in patients and reference significance in guiding clinical medication,so it is worthy of clinical promotion and application.   

  1. Guangzhou Women and Children′s Medical Center,Guangzhou 510623,China
  • Online:2021-06-25 Published:2021-12-15

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Abstract: Objective: To conduct a Meta-analysis of the efficacy of Weiqi Yingxue differentiation in the treatment of Kawasaki disease.
Methods: Through computer and manual retrieval of keywords,search related literatures by logging into major database websites at home and abroad,and collect the literatures of randomized controlled clinical studies on the treatment of Kawasaki disease with Weiqi Yingxue differentiation published at home and abroad from 2005 to 2019.Through quality evaluation,supplementary and re-screening were conducted according to the inclusion criteria of literature.Intervention measures were Weiqi Yingxue differentiation treatment and conventional western medicine treatment.RevMan 5-3 software was used to make a meta-analysis of the included literatures that met the standards.It mainly included significantly effective rate,effective rate,heterogeneity and publication bias.
Results: A total of 195 relevant literatures were retrieved,and a total of 701 children with Kawasaki disease in 10 literatures were finally included.The significant effective and effective heterogeneity were:χ2=6.09,P=0.73;χ2=2.61,P=0.98.The results showed that there was no heterogeneity.When using Weiqi Yingxue differentiation combined with gamma globulin and pure gamma globulin to treat Kawasaki disease,the significant effective rate combined with OR=1.97,95% CI (1.44,2.68),overall effect test Z=4.29 (P<0.000 1).The effective rate was combined with OR=3.92,95% CI (2.24,6.86),and the overall effect test Z=4.77 (P<0.000 01).The difference was statistically significant.Meta-analysis showed that the total significantly effective rate and total effective rate of Weiqi Yingxue differentiation in the treatment of Kawasaki disease were significantly better than those of western medicine alone (P<0.05).
Conclusion: The total significantly effective rate and total effective rate of Weiqi Yingxue differentiation combined with gamma globulin in the treatment of Kawasaki disease are significantly higher than those of gamma globulin alone,which has certain advantages in improving the clinical efficacy in patients and reference significance in guiding clinical medication,so it is worthy of clinical promotion and application.

Key words: Kawasaki disease, Weiqi Yingxue differentiation, Randomized controlled trial, Meta-analysis