基于网状Meta分析探讨10种中成药辅助治疗儿童肺炎支原体肺炎的临床疗效

doi:10.3969/j.issn.1674-3865.2021.03.002

Abstract

Abstract: Objective: To evaluate the efficacy of 10 Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia (MPP) in children through a network meta-analysis system.Methods: Search the CNKI,VIP,CBM,Wan Fang Date,Pubmed,Cochrane Library databases,the search time being from the establishment of the database to September 2020;the literatures on clinical trials of Chinese patent medicine combined with azithromycin in the treatment of children with MPP was collected.Two reviewers screened the literatures,extracted data,and evaluated the quality of the literatures independently.The clinical effectiveness was used as the outcome index.Revman 5.4 and Stata 14.0 softwares were used to conduct network meta-analysis.Results: A total of 48 literatures involving 4 895 children with MPP were included,concerning 10 Chinese patent medicines.The network meta-analysis showed:The clinical effectiveness of the combination of Huanglian Granules/Oral Liquid,Xiao′er Chiqiao Qingre Granules,Xiaoer Feike Granules,Xiaoer Feire Kechuan Oral Liquid,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Tuire Granules,Jinzhen Oral Liquid,Magan Granules and Podilan Antipyretic Oral Liquid with azithromycin in the treatment of children′s MPP was better than that of azithromycin alone.The other drugs showed no statistical difference when compared between each two.According to the ranking results of the surace under cumulative ranking area (SUCRA) value of different oral Chinese patent medicines,the top 4 medicines in terms of improving clinical efficiency were:Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules.Conclusion: Chinese patent medicine assisting azithromycin in the treatment of children with MPP can improve the clinical effectiveness,and the effects of Xiaoer Feike Granules,Xiaoer Xiaoji Zhike Oral Liquid,Chaigui Antipyretic Granules and Xiao′er Chiqiao Qingre Granules are better than other Chinese patent medicines.

Key words: Mycoplasma pneumoniae pneumonia, Chinese patent medicine, Azithromycin, Network meta-analysis

ZHONG Runfeng, WU Zhenqi, HOU Hongbin, REN Yuanyuan, WANG Xuefei. Exploration of the clinical efficacy of 10 kinds of Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(3): 191-196.

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Exploration of the clinical efficacy of 10 kinds of Chinese patent medicines in adjuvant treatment of Mycoplasma pneumoniae pneumonia in children

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