ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (3): 237-240.

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Therapeutic effect and analysis of syndrome-differentiated treatment for children with Henoch-Schonlein purpuranephritis with traditional Chinese medicine

Objective: To explore the clinical effect of syndrome-differentiated treatment for children with Henoch-Schonlein purpura nephritis(HSPN) with traditional Chinese medicine.#br# Methods: A total of 62 childrenwith HSPN admitted to our hospital from September 2017 to June 2019 were selected as the research subjects, and they were randomly divided into control group and observation group, with 31 cases in each group. The control group was treated with conventional western medicine, and the observation group received modified TCM treatment based on syndrome differentiation as well as western medicine. Patients in both groups were treated for 20 weeks continuously. The clinical efficacy and the changes in urinary protein and erythrocyte count in 24 h before and after treatment were compared between the two groups.#br# Results: After 20 weeks of treatment, the total effective rate of the observation group was 96.8% (30/31), which was significantly higher than that of the control group(74.2%,23/31), and the difference was statistically significant(P<0.05). The 24 h urine protein quantity and urine red blood cell count in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).#br# Conclusion: The treatment with TCM based on syndrome differentiation has significant curative effect and can prevent kidney damage, which is worthy of clinical promotion.   

  1. Children's Hospital of Kaifeng, Kaifeng 475000,China
  • Published:2021-06-25 Online:2021-12-17

Abstract: Objective: To explore the clinical effect of syndrome-differentiated treatment for children with Henoch-Schonlein purpura nephritis(HSPN) with traditional Chinese medicine.
Methods: A total of 62 childrenwith HSPN admitted to our hospital from September 2017 to June 2019 were selected as the research subjects, and they were randomly divided into control group and observation group, with 31 cases in each group. The control group was treated with conventional western medicine, and the observation group received modified TCM treatment based on syndrome differentiation as well as western medicine. Patients in both groups were treated for 20 weeks continuously. The clinical efficacy and the changes in urinary protein and erythrocyte count in 24 h before and after treatment were compared between the two groups.
Results: After 20 weeks of treatment, the total effective rate of the observation group was 96.8% (30/31), which was significantly higher than that of the control group(74.2%,23/31), and the difference was statistically significant(P<0.05). The 24 h urine protein quantity and urine red blood cell count in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).
Conclusion: The treatment with TCM based on syndrome differentiation has significant curative effect and can prevent kidney damage, which is worthy of clinical promotion.

Key words: Henoch-Schonlein purpura, Kidney damage, Traditional Chinese medicine based on syndrome differentiation, Children