儿童传染性单核细胞增多症临床特征分析

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (3): 240-242.

Analysis of clinical characteristics of infectious mononucleosis in children

Objective: To analyze the clinical characteristics of children with infectious mononucleosis(IM) and to further guide clinical diagnosis and treatment.#br# Methods: A total of 119 hospitalized children with IM diagnosed in our hospital from January 1, 2017 to December 31, 2019 were selected as the observation group, and 62 healthychildren were selected as the control group. Clinical and laboratory data were obtained and analyzed.#br# Results: The results showed that 31 cases (26.05%) were IgA positive to EB virus antibody, 107 cases(89.92%) were IgM positive, and 33 cases(27.73%) were IgG positive. There were 54 patients with atypical lymphocytes ≥10%(45.37%).There were 35 cases(29.41%) complicated with IgM antibody positive.CD3+ and CD3+CD8+ were significantly higher in 83 patients with improved cellularimmune function than in the control group(P<0.01);CD3+CD4+, CD4+/CD8+, and CD19+ were significantly lower than those in the control group(P<0.05);59 cases (49.58%) were with impaired liver function.#br# Conclusion: Positive IgM antibody in acute stage of IM is an important basis for clinical diagnosis. The dysfunction of cellular immunity and abnormal liver function caused by IM are common. The morphological changes of peripheral blood cells are obvious in the early stage of disease. Therefore, the analysis of clinical characteristicsof children with IM is helpful to guide clinicians in the early diagnosis and treatment of the disease, contributing to the early analysis of the disease condition, formulation of medication regimen and judgment of prognosis.

Department of Pediatrics, Suzhou Municipal Hospital(Suzhou Hospital Affiliated to Nanjing Medical University),Suzhou 215002,China

Online:2021-06-25 Published:2021-12-17

Abstract

Abstract: Objective: To analyze the clinical characteristics of children with infectious mononucleosis(IM) and to further guide clinical diagnosis and treatment.
Methods: A total of 119 hospitalized children with IM diagnosed in our hospital from January 1, 2017 to December 31, 2019 were selected as the observation group, and 62 healthychildren were selected as the control group. Clinical and laboratory data were obtained and analyzed.
Results: The results showed that 31 cases (26.05%) were IgA positive to EB virus antibody, 107 cases(89.92%) were IgM positive, and 33 cases(27.73%) were IgG positive. There were 54 patients with atypical lymphocytes ≥10%(45.37%).There were 35 cases(29.41%) complicated with IgM antibody positive.CD3+ and CD3+CD8+ were significantly higher in 83 patients with improved cellularimmune function than in the control group(P<0.01);CD3+CD4+, CD4+/CD8+, and CD19+ were significantly lower than those in the control group(P<0.05);59 cases (49.58%) were with impaired liver function.
Conclusion: Positive IgM antibody in acute stage of IM is an important basis for clinical diagnosis. The dysfunction of cellular immunity and abnormal liver function caused by IM are common. The morphological changes of peripheral blood cells are obvious in the early stage of disease. Therefore, the analysis of clinical characteristicsof children with IM is helpful to guide clinicians in the early diagnosis and treatment of the disease, contributing to the early analysis of the disease condition, formulation of medication regimen and judgment of prognosis.

Key words: Infectious mononucleosis, Epstein Barr virus infection, Cellular immune function, Children

BAO Lili, JI Chenlin, WU Ping, ZHAO Kai. Analysis of clinical characteristics of infectious mononucleosis in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(3): 240-242.

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Analysis of clinical characteristics of infectious mononucleosis in children

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