ISSN 1674-3865  CN 21-1569/R
主管：国家卫生和计划生育委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
Chinese Pediatrics of Integrated Traditional and Western Medicine

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (4): 328-.

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Different doses of dexmedetomidineby nasal dripping in surgery for pediatric hernia

Objective:To investigate the efficacy and safety of dexmedetomidine (DEX) by nasal dripping in surgery for pediatric hernia.#br# Methods:A total of 90 children undergoing elective hernia surgery were divided into 3 groups with 30 cases in eachgroup by random number table method. They were divided into saline solution control group (control group), DEX 1.0 μg/kg group (low dose group), DEX 2.0 μg/kg group (high dose group).The time of anesthesia, operation, wake-up and extubation and total dosage of remifentanil and propofol during anesthesia were recorded, respectively. HR and SpO-2 were recorded before and at 10 min, 20 min and 30 min after intranasal DEX administration. After the operation, the agitation was evaluated by agitation scoring method on wake-up and at 15 min, 30 min and 60 min after wake-up.#br# Results:There was no statistically significant difference in the time of anesthesia, operation, wake-up and extubation among the 3 groups(P>0.05). The dosage of remifentanil and propofol in control group was significantly higher than that in the other two groups, and the dosage in the high dose group was significantly lower than that in the low dose group, the difference being statistically significant. There was no significant difference in the HR at any time points(P>0.05). Compared with SpO-2before intranasal DEX administration, SpO-2 in low dose group was decreased at 30 min(P<0.05), and SpO-2 was decreased at every time points after intranasal administration in high dose group(P<0.05). SpO-2 in high dose group was significantly lower than that of control group at every time points(P<0.05). The agitation scores after at each time point after wake-up in the high dose group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05).#br# Conclusion:Nasal dripping pretreatmentwith 2.0 μg/kg DEX can significantly reduce the dosage of other intravenous anesthetics and the occurrence of agitation during hernia operation without prolonging the time of wake-up, which is worthy of clinical promotion and popularization.   

  1. Liaoning Health Industry Group Benxi Steel General Hospital，Benxi 117000，China
  • Online:2021-08-25 Published:2021-12-10

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Abstract: Objective:To investigate the efficacy and safety of dexmedetomidine (DEX) by nasal dripping in surgery for pediatric hernia.
Methods:A total of 90 children undergoing elective hernia surgery were divided into 3 groups with 30 cases in eachgroup by random number table method. They were divided into saline solution control group (control group), DEX 1.0 μg/kg group (low dose group), DEX 2.0 μg/kg group (high dose group).The time of anesthesia, operation, wake-up and extubation and total dosage of remifentanil and propofol during anesthesia were recorded, respectively. HR and SpO-2 were recorded before and at 10 min, 20 min and 30 min after intranasal DEX administration. After the operation, the agitation was evaluated by agitation scoring method on wake-up and at 15 min, 30 min and 60 min after wake-up.
Results:There was no statistically significant difference in the time of anesthesia, operation, wake-up and extubation among the 3 groups(P>0.05). The dosage of remifentanil and propofol in control group was significantly higher than that in the other two groups, and the dosage in the high dose group was significantly lower than that in the low dose group, the difference being statistically significant. There was no significant difference in the HR at any time points(P>0.05). Compared with SpO-2before intranasal DEX administration, SpO-2 in low dose group was decreased at 30 min(P<0.05), and SpO-2 was decreased at every time points after intranasal administration in high dose group(P<0.05). SpO-2 in high dose group was significantly lower than that of control group at every time points(P<0.05). The agitation scores after at each time point after wake-up in the high dose group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05).
Conclusion:Nasal dripping pretreatmentwith 2.0 μg/kg DEX can significantly reduce the dosage of other intravenous anesthetics and the occurrence of agitation during hernia operation without prolonging the time of wake-up, which is worthy of clinical promotion and popularization.

Key words: Hernia, Dexmedetomidine, Anesthesia, Postoperative agitation, Nasal dripping, Children