益气化瘀清热方治疗小儿激素敏感型肾病综合征疗效评价分析

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (4): 358-.

Evaluation of therapeutic effect of Yiqi Huayu Qingre decoction on pediatric hormone-sensitive nephrotic syndrome

Objective: To observe the curative effect of Yiqi Huayu Qingre decoction on hormone-sensitive nephrotic syndrome in children.#br# Methods: A total of 69 outpatients or inpatients with hormone-sensitive nephrotic syndrome treated in the First Affiliated Hospital of Henan University of Chinese Medicine and Zhengzhou Children's Hospital from July 2017 to July 2018 were enrolled in this study. Prospective cohort study was used. The 32 outpatients or inpatients with hormone-sensitive nephrotic syndrome in the First Affiliated Hospital of Henan University of ChineseMedicine were treated with Yiqi Huayu Qingre decoction on the basis of western medicine(observation group), and the 37 children with hormone-sensitive nephrotic syndrome treated with western medicine in outpatient or inpatient department of Zhengzhou Children's Hospital were selected as the control group. The control group was treated with glucocorticoid, and the observation group was treated with Yiqi Huayu Qingredecoction on the basis of glucocorticoid. The efficacy and hormone-related side effects were observed before treatment and 2 weeks,4 weeks,8 weeks,12 weeks and 36 weeks after treatment.#br# Results:After 2 weeks of treatment, there were 15 cases of complete remission and 17 cases of partial remission in observation group. In the control group,6 cases were completely relieved,28 cases were partially relieved, and 3 cases were not relieved. The curative effect of the observation group was better than that of the control group, and the difference was statistically significant(P=0.008).During the 36-week treatment, the recurrence rate of the observation group was 12.5%(4/32),which was significantly lower than that of the control group(35.1%,13/37),and the difference was statistically significant(P=0.048).The incidence of infection in the observationgroup was 31.3%(10/32),which was lower than 59.5%(22/37) in the control group, and the difference was statistically significant(P=0.029).There was no significant difference in buffalo hump or moon facecaused by hormones between the two groups(P>0.05).After 8 weeks of treatment, the sweating score and irritability score of the observation group were significantly lower than those of the control group, and the differencewas statistically significant(P<0.05).#br# Conclusion: Yiqi Huayu Qingre decoction can shorten the remissiontime of nephrotic syndrome, reduce the number of infections, reduce the recurrence rate, and reduce the sweating and irritability caused by hormones.

The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China

Online:2021-08-25 Published:2021-12-13

Abstract

Abstract: Objective: To observe the curative effect of Yiqi Huayu Qingre decoction on hormone-sensitive nephrotic syndrome in children.
Methods: A total of 69 outpatients or inpatients with hormone-sensitive nephrotic syndrome treated in the First Affiliated Hospital of Henan University of Chinese Medicine and Zhengzhou Children's Hospital from July 2017 to July 2018 were enrolled in this study. Prospective cohort study was used. The 32 outpatients or inpatients with hormone-sensitive nephrotic syndrome in the First Affiliated Hospital of Henan University of ChineseMedicine were treated with Yiqi Huayu Qingre decoction on the basis of western medicine(observation group), and the 37 children with hormone-sensitive nephrotic syndrome treated with western medicine in outpatient or inpatient department of Zhengzhou Children's Hospital were selected as the control group. The control group was treated with glucocorticoid, and the observation group was treated with Yiqi Huayu Qingredecoction on the basis of glucocorticoid. The efficacy and hormone-related side effects were observed before treatment and 2 weeks,4 weeks,8 weeks,12 weeks and 36 weeks after treatment.
Results:After 2 weeks of treatment, there were 15 cases of complete remission and 17 cases of partial remission in observation group. In the control group,6 cases were completely relieved,28 cases were partially relieved, and 3 cases were not relieved. The curative effect of the observation group was better than that of the control group, and the difference was statistically significant(P=0.008).During the 36-week treatment, the recurrence rate of the observation group was 12.5%(4/32),which was significantly lower than that of the control group(35.1%,13/37),and the difference was statistically significant(P=0.048).The incidence of infection in the observationgroup was 31.3%(10/32),which was lower than 59.5%(22/37) in the control group, and the difference was statistically significant(P=0.029).There was no significant difference in buffalo hump or moon facecaused by hormones between the two groups(P>0.05).After 8 weeks of treatment, the sweating score and irritability score of the observation group were significantly lower than those of the control group, and the differencewas statistically significant(P<0.05).
Conclusion: Yiqi Huayu Qingre decoction can shorten the remissiontime of nephrotic syndrome, reduce the number of infections, reduce the recurrence rate, and reduce the sweating and irritability caused by hormones.

Key words: Nephrotic syndrome, Yiqi Huayu Qingre decoction, Curative effect evaluation, Hormone-related side effect, Children

GAO Xuguang, YANG Meng, ZHANG Maohua, ZHAI Wensheng. Evaluation of therapeutic effect of Yiqi Huayu Qingre decoction on pediatric hormone-sensitive nephrotic syndrome[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(4): 358-.

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Evaluation of therapeutic effect of Yiqi Huayu Qingre decoction on pediatric hormone-sensitive nephrotic syndrome

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