Abstract:

Objective To explore the effect of mild hypothermia on neonatal hypoxic ischemic encephalopathy(HIE).Methods A total of 45 HIE children who were admitted to our hospital within 6 to 24 hours after birth were randomly divided into treatment group and control group with 45 in each group. The control group was treated with routine treatment and rhEPO 500 U/(kg·time), 3 times/week for 2 weeks. The treatment group was treated with systemic mild hypothermia for 72 hours in addition to the treatment for control group. All children were monitored by aEEG before treatment and 3 days after treatment. Neurological scores were measured on day 3, 5 and 7 after birth. Neonatal neurobehavioral assessment(NBNA) was performed on day 7, 14 and 28 after birth. Developmental quotient(DQ) was measured at 3 and 6 months after birth.Results The aEEG scores of the treatment group were significantly higher than those of the control group after 3 days of treatment(P<0.05), while there was no difference in neurological scores between the two groups at 3 days after birth(P>0.05).The neurological scores at 5 and 7 days after birth were lower in the treatment group than in the control group(P<0.05). The neonatal neurobehavioral scores at 7, 14 and 28 days after birth were higher in the treatment group were higher than those in control group(P<0.05). The scores in developmental quotient at 3 and 6 months after birth were higher in treatment group than in control group(P<0.05).Conclusion For neonatal hypoxic-ischemic encephalopathy, delayed systemic hypothermia treatment starting from 6 to 24 hours after birth can promote the early recovery of neurological function in HIE children.

Key words:

Neonatal hypoxic ischemic encephalopathy, Delayed, Hypothermia, Curative effect