Abstract: ObjectiveTo make a Meta-analysis of the main risk factors for neonatal nosocomial infection, so as to further improve medical preventive measures and reduce the incidence of neonatal nosocomial infection.Methods Both Chinese and foreign databases were searched, and STATA/SE 12.0 software was used for Meta-analysis.Results Totally 52 studies were included, involving 94 223 neonates with infection. Meta-analysis showed that 12 risk factors were with statistically significant difference, including gestational age <37 weeks(RR=0.92, 95%CI=0.90-0.93), birth weight<2 500 g(RR=0.92, 95%CI=0.91-0.94), hospital stay>7 days (RR=0.93, 95%CI=0.91-0.95), mechanical ventilation (RR=0.88, 95%CI=0.85-0.91), parenteral nutrition(RR=0.92, 95%CI=0.89-0.96), invasive procedures(RR=0.89, 95%CI=0.84-0.93), intravenous catheterization(RR=0.91, 95%CI=0.83-0.99), neonatal asphyxia(RR=0.94, 95%CI=0.89-0.99), mode of delivery (RR=0.93, 95%CI=0.88-0.98), PICC (RR=0.84, 95%CI=0.74-0.96), amniotic fluid turbidity (RR=0.91, 95%CI=0.85-0.96) and breast feeding (RR=0.93, 95%CI=0.87-1.00), which were risk factors for neonatal infection. Sensitivity analysis and publication bias results showed that the publication bias was not obvious.ConclusionIn neonatal nursing and clinical work, medical staff should improve the identification and judgment of risk factors for neonatal infection and actively take preventive measures in order to reduce the morbidity and mortality of neonatal nosocomial infection.

Key words: Nosocomial infection, Meta-analysis, Risk factors, Neonates