Abstract:
Objective:To observe the effect of Guben Zhixiao prescription in the prevention of asthma in young rats.
Methods:Take 100 young rats,but select only 60,who were divided into 5 groups randomly;the blank group and the model group were given physiological saline stomach irrigation for 28 days,the other 3 groups with 28 days of medicine irrigation.Except the blank group,asthma model was made in all the other groups(by egg albumin all(OVA) intraperitoneal injection sensitization and  atomization inhalation stimulation).Observe the effect of irrigation in rat stomach on day 14 on the incubation period;when rats had contact with 1% OVA smog for the first time observe if there was symptoms of asthma and record the level,compare the asthma incidence(level 3) among the groups.
Results:(1)After 14 days of irrigation and compared with the model group,Guben Zhixiao prescription in large or small dose had longer incubation period,which had significant difference(P<0.05).(2)Compared with the model group at the first time of contact between rat and 1% OVA aerosol,Guben Zhixiao prescription apparently reduced asthma level,with significant difference(P<0.05);(3)On 4 and 7 days of stimulation,and compared with model group in Guben Zhixiao prescription in large or small dose group,level 3 asthma rates had a significant decrease,with significant difference(P<0.05).
Conclusions:Guben Zhixiao prescription can extend the incubation period in rats,reduce asthma rates,reduce asthma degree,and has good prevention and cure effect on the young rats asthma.