Abstract:
Henoch-Schonlein purpura(HSP) is the common vasculitis affecting mainly children. In recent years, the incidence of HSP has been increasing while its pathogenesis is still unclear. Studying the pathogenesis of HSP from the gene level becomes one of the hotspots in the research field. Recently some studies have shown that the gene polymorphism of certain cytokines are related to the pathogenesis, pathological progression and prognosis of HSP, e.g., interleukin gene, angiotensinogen gene, human leukocyte antigen gene, and vascular endothelial growth factor gene, etc. Through the literature review and comprehensive analysis of the related cytokine polymorphisms, this paper provides references for future research on the pathogenesis of HSP from gene level.

Key words: Henoch-Schonlein purpura, Cytokine, Gene polymorphism, Children