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25 August 2018, Volume 10 Issue 4 Previous Issue    Next Issue

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Effects of ginseng Rg1 on hippocampal neuronal apoptosis and learning ability of neonatal rats with hypoxic-ischemic brain damage LEI Xunming 2018, 10 (4):  277-279.  doi: 10.3969/j.issn.1674-3865.2018.04.001 Abstract ( 936 )   PDF (340KB) ( 433 )   Save Objective:To investigate the effects of ginseng Rg1 on hippocampal neuronal apoptosis and learning ability of neonatal rats with hypoxic-ischemic brain damage.Methods:A total of 60 15-day SD rats were chosen and randomly divided into 3 groups: HIBD group, ginseng Rg1 low-dose group and high-dose group, 20 rats in each group. After surgery, ginseng Rg1 was peritoneally injected at 20 μg/g and 10 μg/g every day in the high-dose and low-dose group, while normal saline was injected in HIBD group. The injection continued for 25 days. TUNEL method was used to detect the neuronal apoptosis in hippocampal CA1 area, the learning ability and memory of the rats in each group were tested, and the correct response rate was calculated.Results:The number of TUNEL positive cells in hippocampus CA1 area of low-dose group and high-dose group was lower than that of HIBD group, and the number of TUNEL positive cells in hippocampus CA1 area of high-dose group was lower than that in low-dose group(P<0.05). The correct response rate of learning ability and memory test in low-dose group and high-dose group was higher than that in HIBD group. The correct response rate of learning ability and memory test in high-dose group was higher than that in low-dose group(P<0.05).Conclusion:Ginseng Rg1 can reduce the apoptosis of hippocampal neurons in neonatal rats with hypoxic-ischemic brain damage, and effectively improve the learning ability and memory of these rats. Related Articles | Metrics

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Bacteriostatic effect of Gui-Fei-Jing Chinese medicine extract on Mycoplasma pneumoniae CEN Kaiying, WANG Haiying 2018, 10 (4):  280-282.  doi: 10.3969/j.issn.1674-3865.2018.04.002 Abstract ( 861 )   PDF (393KB) ( 583 )   Save Objective:To observe the effect of the water extract or ethanol extract of Houttuynia (H. cordata), pberetima and Cortex Mori, whether in compound, or used alone, or used by combining either two of them, in inhibiting Mycoplasma pneumoniae in vitro.Methods:Mycoplasma pneumoniae was cultured and the drug sensitivity test was performed. MIC method was used to determine the in vitro inhibitory effect of each group of combination on Mycoplasma pneumoniae.Results:All groups had inhibitory effect on Mycoplasma pneumoniae. Among them, the MIC value in the ethanol extract of compound group, which was significantly lower than that in the water extract and the ethanol extract of Houttuynia cordata，the water extract and the ethanol extract of Cortex Mori, the water extract and the ethanol extract of the combination group of pberetima and Cortex Mori,and the water extract and the ethanol extract of the combination group of Cortex Mori and Houttuynia cordata,the difference being statistically significant（P<0.01）.Conclusion:The Chinese medicine extract has bacteriostatic effect, and if used in combination, the effect will be enhanced. Related Articles | Metrics

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Research progress of gene polymorphism of cytokines in Henoch-Schonlein purpura XI Leying, REN Xianqing 2018, 10 (4):  282-286.  doi: 10.3969/j.issn.1674-3865.2018.04.003 Abstract ( 888 )   PDF (608KB) ( 324 )   Save Henoch-Schonlein purpura(HSP) is the common vasculitis affecting mainly children. In recent years, the incidence of HSP has been increasing while its pathogenesis is still unclear. Studying the pathogenesis of HSP from the gene level becomes one of the hotspots in the research field. Recently some studies have shown that the gene polymorphism of certain cytokines are related to the pathogenesis, pathological progression and prognosis of HSP, e.g., interleukin gene, angiotensinogen gene, human leukocyte antigen gene, and vascular endothelial growth factor gene, etc. Through the literature review and comprehensive analysis of the related cytokine polymorphisms, this paper provides references for future research on the pathogenesis of HSP from gene level. Related Articles | Metrics

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Meta-analysis of the effect of erythropoietin on neonates with hypoxic-ischemic encephalopathy ZHANG Yaodong, TAN Lina, KANG Wenqing, XU Bangli, LIU Dapeng, WANG Caijun 2018, 10 (4):  287-291.  doi: 10.3969/j.issn.1674-3865.2018.04.004 Abstract ( 707 )   PDF (2225KB) ( 84 )   Save Objective:To investigate the clinical efficacy of erythropoietin in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE) from the perspective of evidence based medicine.Methods:The Chinese Journal Net, Wanfang Database, Chongqing Weipu, Chinese Biomedical Literature Database and Pubmed were searched for the related literatures of HIE treated by erythropoietin. According to the clinical inclusion and exclusion criteria, Revman 5.1 software was used to analyze the conditions of included literature to evaluate the neonatal neurobehavioral scores at 7,14,and 28 days of treatment and the development indexes at 3 and 6 months.Results:Fifteen articles were included in the Meta-analysis, including 502 cases in the study group and 500 cases in the control group. Meta analysis at 7 days of treatment showed that OR=2.73(95%CI,0.73-4.73,Z=2.68,P=0.007). The results at 14 days showed that OR=1.78(95%CI,0.84-2.73，Z=3.70,P=0.000 2). The results of Meta analysis at 28 days showed that OR=2.34(95%CI,0.66-4.03,Z=2.73,P=0.006).3 months MDI and PDI Meta-analysis showed that OR=2.53(95%CI,1.72-3.72)，2.48(95%CI,1.66-3.73)，Z=4.70,4.40，P＜0.000 1; at 6 months, MDI and PDI Meta-analysis results suggested that OR=2.85(95%CI,1.68-4.82),2.77(95%CI,1.67-4.72)，Z=3.89,3.93,P＜0.000 1. There was no bias in the publication of all studies.Conclusion:Eperythropoietin for HIE can significantly improve neonatal neurobehavior and promote mental development. Related Articles | Metrics

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Observation on the effect of Xiaoji Zhisou decoction in the treatment of children with cough due to dyspepsia YIN Qihui 2018, 10 (4):  292-294.  doi: 10.3969/j.issn.1674-3865.2018.04.005 Abstract ( 846 )   PDF (403KB) ( 201 )   Save Objective:To observe the clinical effect of Xiaoji Zhisou decoction  in the treatment of children with cough due to dyspepsia.Methods:From March 2015 to March 2016, 96 children with dyspepsia cough(acute bronchitis) were treated in our hospital and they were randomly divided into observation group(n=50) and control group(n=46). The observation group was treated with Xiaoji Zhisou decoction and the control group with children's Qingfei oral liquid. The therapeutic effect and the recovery time of main TCM syndromes were compared between the two groups after a 15-day treatment.Results:The curative effect of the observation group was significantly higher than that of the control group after 15 days of treatment, and the difference was statistically significant(P<0.05). In the observation group, the recovery time of cough, expectoration, abdominal distension, constipation and defecation, and the main TCM syndromes of halitosis and hand and foot heat was significantly shorter than that in the control group(P<0.05).Conclusion:The effect of Xiaoji Zhisou decoction on dyspepsia cough is remarkable. Related Articles | Metrics

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Clinical effect of Children's Intelligence syrup for tic disorders KONG Min, HAO Aiqing, CHEN Bingtao, REN Lizhong 2018, 10 (4):  295-297.  doi: 10.3969/j.issn.1674-3865.2018.04.006 Abstract ( 1296 )   PDF (378KB) ( 162 )   Save Objective:To observe the clinical efficacy of Children＇s Intelligence syrup in the treatment of children with transient tic disorders.Methods:A total of 60 children with transient tic disorders were included in the study, who visited in the Pediatric Department of Qufu Hospital of Traditional Chinese Medicine between Jul. 2016 and Feb. 2018, and they were randomly divided into experimental group and control group, with 30 children in each group. The experimental group took Children＇s Intelligence syrup orally, and the control group took tiapride hydrochloride orally. Two groups were treated for 3 months as a course. The clinical efficacy was evaluated by Yale Globe Tic Severity Scale(YGTSS) with 5 dimensional scores (number, frequency, intensity, complexity and interference). The drug safety was evaluated by Treatment Emergent Symptom Scale(TESS).Results:The total scores of YGTSS of two groups after treatment were significantly lower than those before treatment, there being statistical difference（P<0.05）. The total scores of YGTSS of the experimental group were similar to those of the control group after treatment, and the difference was not statistically significant（P>0.05）. The total effective rate of two groups was similar, the difference being not statistically significant（P>0.05）. The total scores of TESS of the experimental group (2.05±0.18) were significantly lower than those of the control group（13.55±4.82）, there being statistical difference（P<0.05）.The main adverse reactions in experimental group were mild gastrointestinal reactions and those in control group were drowsiness, dizziness, nausea and worse school performance.Conclusion:Children＇s Intelligence syrup has significant effect in the treatment of children with tic disorders, which has fewer adverse reactions and higher safety, so it is worth the clinical promotion and application. Related Articles | Metrics

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Clinical effect of absorbable material in the treatment of children with Trapdoor suborbital fracture TANG Xia, TONG Huijuan, QIU Feng 2018, 10 (4):  298-300.  doi: 10.3969/j.issn.1674-3865.2018.04.007 Abstract ( 776 )   PDF (373KB) ( 200 )   Save Objective:To study the effect of absorbable material in the treatment of Trapdoor suborbital fracture in children.Methods:A total of 69 children with Trapdoor suborbital fracture were treated in Shenyang Fourth People's Hospital from Mar. 2015 to Mar. 2017. The clinical data of these children before and after surgery were analyzed and summarized, including visual function, ambiopa, eye movement, degree of ocular proptosis, and the CT results of orbit. A 6 month follow up was conducted to instruct the children to do eye muscle training.Results:After 6 months of treatment, ambiopa disappeared in 59 cases; there was no ambiopa in the front reading position or only a little residual ambiopa existed in the surrounding area in 7 cases; there was residual ambiopa in the front reading position in 3 cases. There was no exacerbation in ambiopa or the eye movement limitation in all the children. The difference in the degree of ocular proptosis of both eyes were within 2 mm in all the child patients. One child had permanent suborbital nerve damage. No children had rejection or infection after surgery.Conclusion:Early use of absorbable material in the treatment of children with Trapdoor suborbital fracture and eye muscle training after surgery result in good recovery of children. Related Articles | Metrics

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Analysis of the effect of TCM therapy on the temporal and spatial parameters of the gait in spasmodic cerebral palsy based on 3D gait system HU Xiaoli, WANG Xuefeng, HAN Yang 2018, 10 (4):  300-303.  doi: 10.3969/j.issn.1674-3865.2018.04.008 Abstract ( 717 )   PDF (529KB) ( 432 )   Save Objective:To evaluate the treatment effect of TCM therapy on spasmodic cerebral palsy based on the data of gait parameters provided by the 3D gait system.Methods:A total of 20 children with cerebral palsy were included in the study, who were treated in the Affiliated Hospital of Liaoning TCM University and Shenyang Children Hospital from Jan. 2014 to Jan.2015. Their gait was detected by 3D gait analysis system on admission and one month after TCM rehabilitation; the data were collected and compared before and after rehabilitation. The rehabilitation therapy was based on the Diagnosis and Treatment Program of Five Late, Five-soft and Five-hard(cerebral palsy) by the Eleventh-Five-Year Key Special Association Group of National TCM Administration Agency. The targeted treatment was performed according to the features of gait parameters of these children on admission to the hospital.Results:The length of gait interval in the children of each age group was improved after rehabilitation, and the difference was significantly statistical(P<0.05). The length of supporting on the left side in the children between 3 and 6 years old was improved after rehabilitation, and the length of waving on the right side in children between 7 and 8 years old was improved after rehabilitation, and there was statistical difference(P<0.05). The stride length was also improved in the children of 7 and 8 years old(P<0.05).Conclusion:Based on the 3D gait system, the TCM therapy is more targeted to the improvement of dyskinesia in the children with spasmodic. In addition, 3D gait analysis system is a scientific and objective technology to evaluate the TCM therapy. Related Articles | Metrics

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Observation on the clinical effect of Shenzhe Zhenqi decoction in the treatment of children with multiple tic disorder SONG Shuping 2018, 10 (4):  304-307.  doi: 10.3969/j.issn.1674-3865.2018.04.009 Abstract ( 1023 )   PDF (517KB) ( 146 )   Save Objective:To observe the clinical efficacy of Shenzhe Zhenqi decoction in the treatment of children with multiple tic disorder.Methods:From September 2014 to October 2016, 60 children with multiple tic disorder were admitted to the Pediatric Department of the Second People's Hospital of Anding District, Dingxi City for treatment, and they were randomly divided into observation group and control group(30 in each). The observation group was treated with Shenzhe Zhenqi decoction; the control group was treated with oral haloperidol, and Antan was used when there are side effects of vertebral body. Both groups were treated for 1 course of treatment. Observe the clinical efficacy, the incidence of side effects, the therapeutic effect on TCM syndromes and the long-term prognosis.Results:There was no significant difference in the total effective rate between the observation group(86.7%,26/30) and the control group(83.3%,25/30)(P>0.05). After treatment, the incidence of side effects in the observation group was 0, which was significantly lower than that in the control group (40%,12/30), and the difference was statistically significant(P<0.01). The effective rate of TCM syndromes in the observation group was 100.0% (30/30), which was significantly better than that in the control group (36.7%,11/30). The difference was statistically significant (P<0.05). Two groups of children were re-examined within half a year, and there was no recurrence in the observation group, but two patients in the control group relapsed after emotional stimulation, and the recurrence rate was 6.7%(2/30).Conclusion:Shenzhe Zhenqi decoction has a good curative effect on children with multiple tic disorder. The treatment can be performed from liver, kidney, spleen and lung to restore the function of viscera. Its curative effect is comparable to that of western medicine, and its clinical value is worth promoting. Related Articles | Metrics

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Clinical observation on acupoint application in the treatment of anorexia in children and its effect on appetite regulation factor WANG Liran 2018, 10 (4):  307-310.  doi: 10.3969/j.issn.1674-3865.2018.04.010 Abstract ( 887 )   PDF (497KB) ( 398 )   Save Objective:To discuss the effect of acupoint application of self-made plaster on anorexia in children and its effect on appetite regulation factor.Methods:Eighty children with anorexia were divided into the observation group(n=40) and control group(n=40) at random, Both groups of children were given basic treatment, such as correcting bad eating habits and dietary adjustment. Both groups took bifidobacterium orally, 1.0 g at a time, 3 times a day. The observation group also received acupoint application of self-made plaster, once a day for the first three days in a week, and was suspended for the next four days. The treatment lasted for 4 courses, with 2 weeks in a course. Observe clinical results，TCM syndrome score, serum leptin and neuropeptide Y levels before and after clinical treatment in the two groups. The recurrence rate was observed after 6 months and 1 year of discontinuation was also observed.Results:In the observation group 39 cases completed the treatment and one case lose. In the control group 38 cases completed the treatment, including 1 patient who had withdrawn from treatment due to adhesive allergy, and 1 patient who had anorexia due to secondary diseases. The total clinical effective rate in observation group(94.9%,37/39) was much higher than that in control group(76.3%,29/38)(P<0.05),the difference being statistical. The TCM syndrome score of both groups was lower than that before treatment, and the difference was statistically significant (P<0.05).Serum leptin and neuropeptide Y levels were higher in both groups after treatment than before treatment, and the difference was statistically significant(P<0.05).Serum leptin and neuropeptide Y levels in the observation group were higher than those in the control group after treatment, and the difference was statistically significant (P<0.05).The recurrence rate of children in the observation group was lower than that of the control group at 6 months and 1 year follow up after treatment, and the difference was statistically significant(P<0.05).Conclusion:Acupoint application of plaster combined with bifidobacterium in the treatment of anorexia in children has a good effect, which can significantly improve the nutritional status of children, and the recurrence rate is low, and its effect is related to the increase of serum leptin and neuropeptide Y levels. Related Articles | Metrics

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Clinical effect of iontophoresis of Chinese medicine as adjuvant treatment for children with diarrhea disease WU Jin 2018, 10 (4):  311-313.  doi: 10.3969/j.issn.1674-3865.2018.04.011 Abstract ( 782 )   PDF (409KB) ( 223 )   Save Objective:To observe the clinical effect of iontophoresis of Chinese medicine on the basis of traditional administration in the treatment of children with diarrhea disease.Methods:Totally 64 children with diarrhea disease were included as the research subjects and were randomly divided into observation group and control group, 32 children in each group. These children received treatment in Liangxiang Hospital of Fangshan District from Jan. 2014 to Dec. 2016. Traditional treatment was given to both groups, which was taking bifidobacterium tetravaccine tablets(live) and montmorillonite powder orally. The observation group was also given iontophoresis of Chinese medicine. The treatment lasted for 3 days as a course. After 3 days of treatment, observe the times of bowel movement, the properties of feces, the clinical effect, recovery time and adverse reactions of the two groups.Results:The improvement in times of bowel movement and the properties of feces was better in observation group than in control group(P<0.05). The total effective rate in observation group was 93.8%(30/32),significantly higher than that in control group(71.9%,23/32),the difference being significant(P<0.05).The recovery time of observation group was (5.0±0.9)d, shorter than that of control group［(7.0±1.3)d,P<0.05］.No adverse reaction was observed in both groups.Conclusion:The iontophoresis of Chinese medicine for children with diarrhea disease can shorten the treatment course. It is effective, convenient and without pain or adverse reaction. It is an effective method of treating children with diarrhea disease and worth clinical promotion. Related Articles | Metrics

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Clinical effect of the treatment for children with tic disorder based on "blood" by nourishing blood and eliminating wind XU Rui, ZHANG Xiao 2018, 10 (4):  314-316.  doi: 10.3969/j.issn.1674-3865.2018.04.012 Abstract ( 792 )   PDF (447KB) ( 166 )   Save Objective:To observe the clinical effect of the treatment for children with tic disorders based on "blood" by nourishing blood and eliminating wind.Methods:A total of 82 children with tic disorders were treated in Nanyang First People's Hospital from Jan. 2013 to Jan. 2016, and were included as the research subjects, among whom there were 38 cases of transient tic, 29 cases of chronic tic, and 15 cases of multiple tic. The electroencephalography(EEG) showed abnormal results in 27 cases, of which there were 11 cases of chronic tic, 7 cases of multiple tic and 9 cases of transient tic; among the 27 cases, 16 were with mild nonspecific abnormality, and 11 with moderate abnormality. Based on the treatment principle of nourishing blood and eliminating wind, the prescription of modified Tianma Gouteng Yin was made. The treatment lasted for two courses of treatment, one month as a course. The clinical effect and EEG improvement were observed.Results:The treatment was obviously effective in 56 cases, effective in 21 cases and in effective in 5 cases, the total effective rate being 93.9%（77/82）. Among the 27 cases of abnormal EEG, 13 returned to normal, of which 7 changed from moderate abnormality to mild abnormality. The improvement was not significant in 7 cases.Conclusion:According to the principle of nourishing blood and eliminating wind, the treatment based on "blood" has significant effect on children with tic disorders; it can promote the recovery of brain cells and significantly improve the electrophysiological activities of the brain, which is worth further studies and promotion. Related Articles | Metrics

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Effect of Chinese medicine retention enema combined with diazepam in treatment of febrile convulsion in children LIU Zhengmao 2018, 10 (4):  317-319.  doi: 10.3969/j.issn.1674-3865.2018.04.013 Abstract ( 879 )   PDF (404KB) ( 182 )   Save Objective:To observe the curative effect of intravenous injection of diazepam combined with Chinese medicine retention enema in the treatment of febrile convulsion in children.Methods:A total of 65 children with febrile seizures admitted from September 2015 to September 2017 to Xiangyang Hospital of Traditional Chinese Medicine were selected and randomly divided into two groups: 42 cases in the observation group and 23 cases in the control group. The observation group was treated by the intravenous injection of diazepam and Chinese medicine retention enema, and the control group was given intravenous injection of diazepam and rectal administration of diclofenac sodium. The patients were treated for 3 to 5 days according to the severity of the disease. The total effective rate of the two groups and the recurrence rate of convulsion within 72h were observed.Results:The total effective rate in the observation group(97.6%,41/42) was significantly higher than that in the control group(73.9%,17/23)(P<0.05), and the recurrence rate within 72h in the observation group(2.4%,1/42) was lower than that in the control group(26.1%,6/23)(P<0.05).Conclusion:The effectiveness of intravenous injection of diazepam combined with Chinese medicine retention enema is better than that of intravenous injection of diazepam combined with rectal administration of diclofenac sodium, and the recurrence rate is low. Related Articles | Metrics

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Effect of taking Chinese medicine orally combined with external treatment of pinching spine and inhalation therapy in the treatment of bronchiolitis ZHANG Meifang, ZHANG Qian, LIU Xiaona, JI Hongying, WANG Xiaojie, WANG Yunxia, DONG Qiuju, ZHANG Wenhui 2018, 10 (4):  319-322.  doi: 10.3969/j.issn.1674-3865.2018.04.014 Abstract ( 908 )   PDF (598KB) ( 132 )   Save Objective:To observe the effect of taking Chinese medicine orally combined with external treatment of pinching spine and inhalation therapy in the treatment of bronchiolitis.Methods:A total of 150 children with bronchiolitis treated in our hospital from Aug. 2015 to Oct. 2016 were included in the study, and they were randomly divided into two groups: observation group(75 cases) and control group(75 cases). Both groups were given comprehensive treatment of oxygen inhalation, anti-virus and sputum suction; in addition, compound ipratropium bromide solution and inhaled budesonide solution were given, and antibiotics were used for those with infection. The control group was treated with western medicine and was not intervened after relief; the observation group was treated with integrated Chinese and western medicine: for Chinese medicine, a self-mode prescription was used(5 g of radix sileris, 2 g of dark plum, 2 g of cicada, and 2 g of Ganodorma lucidum), and when the acute symptoms were relieved, Feng's spine-pinching was performed. Observe the relief time of wheezing, the recurrence rate and the clinical effect of the two groups.Results:The disappearance time of wheezing rales and cough in the observation group was significantly shorter than in the control group, and the difference was statistical(P<0.01). The non recurrence rate within one year in observation group was 69.3%(52/75), higher than the control group (38.6%,29/75), and there was statistical difference(P<0.01).After treatment, the total effective rate in observation group was 97.3%(73/75), higher than that in control group(74.7%,56/75), the difference being statistical(P<0.01).Conclusion:Taking Chinese medicine orally combined with external treatment of pinching spine and inhalation therapy has satisfactory effect in the treatment of bronchiolitis, and can prevent recurrent wheezing of this disease. Related Articles | Metrics

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Application of combined detection of white blood cell count, procalcitonin and C-reactive protein in the diagnosis of children with community-acquired pneumonia LENG Xiuzhi 2018, 10 (4):  323-326.  doi: 10.3969/j.issn.1674-3865.2018.04.015 Abstract ( 817 )   PDF (521KB) ( 118 )   Save Objective:To observe the application of combined detection of white blood cell count, procalcitonin and C-reactive protein in the diagnosis of children with community-acquired pneumonia.Methods:A total of 106 children with community-acquired pneumonia treated in our hospital from August 2016 to July 2017 were enrolled as study subjects. According to infection type, the patients were divided into bacteria group(57 cases) and non-bacteria group(49 cases). Bacteria group were divided into Gram-positive bacteria group(26 cases) and Gram-negative bacteria group(31 cases); there were 19 cases in severe infection group and 38 cases in non-severe group. Sixty healthy children in the same period were included as the control group. The WBC, procalcitonin and C-reactive protein levels of the two groups were compared.Results:The level of white blood cell count and procalcitonin level in bacteria group were significantly higher than those in non-bacteria group and control group(P＜0.05); the level of C-reactive protein in bacteria group and non-bacteria group were significantly higher than that in control group(P＜0.05) . The level of procalcitonin and C-reactive protein in severe infection group were significantly higher than that in non-severe group(P＜0.05). The level of procalcitonin in Gram-negative bacteria group was significantly higher than that in Gram-positive bacteria group(P＜0.05), but the level of white blood cell count and C-reactive protein was not statistically different between the two groups. After treatment, the level of white blood cell, procalcitonin and C-reactive protein in bacteria group gradually decreased, which returned to normal level before hospital discharge.Conclusion:The combination detection of peripheral white blood cell, procalcitonin and C-reactive protein can help to make preliminary diagnosis of bacteria and non bacteria infection in children with community-acquired pneumonia. The level of procalcitonin and C-reactive protein can be used to assess the disease severity, guide the clinical antibiotic treatment and evaluate the treatment results. Related Articles | Metrics

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Clinical characteristics and etiology of early-onset and late-onset neonatal sepsis GAO Chuchu, YANG Zuming, WANG Sannan, CAI Yan 2018, 10 (4):  327-329.  doi: 10.3969/j.issn.1674-3865.2018.04.016 Abstract ( 971 )   PDF (336KB) ( 431 )   Save Objective:To analyze the clinical characteristics and pathogenic bacteria distribution of early-onset and late-onset neonatal sepsis, in order to aid in the early clinical diagnosis and treatment.Methods:From Jan. 2017 to Oct. 2017, 28 cases of early-onset neonatal sepsis and 31 cases of late-onset neonatal sepsis were treated in our hospital, and their clinical data were analyzed.Results:The incidence of apnea, abdominal distention and heart rate increase was significantly higher in late onset group (P<0.05). There was no statistical difference in the incidence of abnormal body temperature, milk decrease, jaundice, skin empyesis or shortness of breath. Percentage of elevated C-reactive protein in late-onset group was significantly higher than that in early-onset group (P<0.05). There was no statistical difference in the percentage of abnormal WBC or platelet decrease. Streptococcus agalactiae was detected with the highest frequency in early-onset group(25%,7/28), while klebsiella pneumonia was the most frequently detected strain in late-onset group(38.71%,12/31).Conclusion:The symptoms of apnea, abdominal distention and heart rate increase are more common in late-onset neonatal sepsis than in early-onset neonatal sepsis. C-reactive protein is an important indicator in early evaluation of late-onset neonatal sepsis. Early-onset and late-onset neonatal sepsis differ in the distribution of pathogenic bacteria. Antibiotics should be used according to actual clinical conditions. Related Articles | Metrics

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Clinical Observation on treatment for constipation with lung-heat in children by modified Xiebai powder WANG Haijun, ZHOU Hongyun, ZHAO Qiong, LUO Yating, QIAN Ming 2018, 10 (4):  330-333.  doi: 10.3969/j.issn.1674-3865.2018.04.017 Abstract ( 856 )   PDF (475KB) ( 223 )   Save Objective:To observe the clinical efficacy of the prescription, modified Xiebai powder, in the treatment of constipation(lung heat) in children.Methods:Sixty patients with functional constipation treated in the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January to December 2014 were enrolled in the study. They were randomly divided into observation group and control group(30 in each). The observation group was treated with traditional Chinese medicine decoction, modified Xiebai powder, and the control group was treated with Chinese patent medicine, Maziren pill. The two groups also received basic treatment. The treatment lasted for 2 weeks.Results:The clinical efficacy of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.01). After treatment, the scores of TCM primary syndrome and secondary syndrome of two groups were lower than those before treatment, and the difference was statistically significant (P<0.05). After treatment, the scores of TCM primary syndromes and secondary syndromes in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05).Conclusion:The clinical efficacy of modified Xiebai powder in the treatment of pulmonary heat constipation(lung heat) in children is significant, which is worthy of clinical promotion. Related Articles | Metrics

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Clinical observation on the effect of modified Ganlu Xiaodu Dan in the treatment of children with acute suppurative tonsillitis JIN Songli, GUO Yingying 2018, 10 (4):  333-335.  doi: 10.3969/j.issn.1674-3865.2018.04.018 Abstract ( 975 )   PDF (396KB) ( 749 )   Save Objective:To observe the effect of modified Ganlu Xiaodu Dan as an assistant treatment for children with acute suppurative tonsillitis.Methods:A total of 108 children with acute suppurative tonsillitis were selected as the study subjects. These children were randomly divided into control group and observation group. The children in the control group were treated with conventional western medicine, while for the children in the observation group, a traditional Chinese medicine of modified Ganlu Xiaodu Dan was given besides the same treatment as the control group. The treatment lasted for 5 days as a course. After one course, the time of fever, the time of exudates disappearance, the time of tonsil contraction, the time of congestion relief and the clinical efficacy as well as adverse reactions were compared between the two groups.Results:The cure rate of the observation group was 48.15%（26/54）, and the total effective rate was 98.15%（53/54）, both of which were significantly higher than those of the control group［the cure rate being 27.78%（15/54）, the total effective rate being 85.19%（46/54）］.The difference was statistically significant(P<0.05). The time of fever abatement, the time of exudates disappearance, the time of tonsil contraction and the time of congestion relief in the observation group were significantly shorter than those in the control group. The difference was statistically significant(P<0.05). No adverse reactions were observed in both groups.Conclusion:The clinical effect of modified Ganlu Xiaodu Dan for the children with acute suppurative tonsillitis is definite, which is worthy of clinical application. Related Articles | Metrics

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Detection of ICAM-1 in peripheral blood and RANTES in bronchoalveolar lavage fluid in children with lobar pneumonia and its significance ZHANG Songlin, JIN Xiuhong, SHEN Zhaobo 2018, 10 (4):  336-339.  doi: 10.3969/j.issn.1674-3865.2018.04.019 Abstract ( 739 )   PDF (469KB) ( 160 )   Save Objective:To explore the significances of detection of intercellular adhesion molecule-1(ICAM-1) in peripheral blood and regulated upon activation normal T cell expressed and secreted(RANTES) in bronchoalveolar lavage fluid in children with lobar pneumonia and their correlation in pathogenesis of lobar pneumonia.Methods:A total of 95 children with respiratory diseases were included  as the research subjects, and they were divided into 3 groups: lobar pneumonia group(35 cases),bronchopneumonia group(30 cases) and tracheal stenosis group(control group,30 cases). The expression of ICAM-1 was detected by flow cytometry in lymphocyte of peripheral blood in 35 children with lobar pneumonia and 30 children with bronchopneumonia and 30 children with tracheal stenosis, and the level of RANTES was assayed with ELISA technique in the bronchoalveolar lavage fluid.Results:(1)The expression rate of ICAM-1 in lobar pneumonia group was much higher than that in bronchopneumonia group（P<0.05） and control group（P<0.01）,and it was higher in bronchopneumonia group than in control group（P<0.05）.(2)The level of RANTES in lobar pneumonia group and bronchopneumonia group was higher than that in control group（P<0.05）;however，no significant difference was found between lobar pneumonia group and bronchopneumonia group.(3)There was a positive correlation between ICAM 1 and RANTES in lobar pneumonia group(r=0.781，P＜0.01); however，no correlation was found in bronchopneumonia group and control group.Conclusion:ICAM-1 and RANTES are involved in the development of lobar pneumonia and play a synergistic role in it, so they can be used as indicators of lobar pneumonia, which provides theoretical basis for studying the pathogenesis of lobar pneumonia. Related Articles | Metrics

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Analysis of expression level of peripheral regulatory T cells and helper T cells in asthma children at stage of attack HAO Liangliang, ZHAO Yajuan, YANG Xiaotong, LI Zhe 2018, 10 (4):  340-343.  doi: 10.3969/j.issn.1674-3865.2018.04.020 Abstract ( 624 )   PDF (447KB) ( 146 )   Save Objective:To analyze the expression levels of peripheral regulatory T cells and helper T cells in asthma children at stage of attack.Methods:Totally 55 children with bronchial asthma treated in Shenyang Children's Hospital from Oct. 2016 to Dec. 2016 were chosen as the research subjects. According to the TCM syndrome type, they were divided into two groups: 26 in cold type asthma group and 29 in heat type asthma group. Another 28 children who were healthy on the physical examination during the same period were included as the control group. All the three groups of children received determination of the expression level of regulatory T cells(CD4 CD25+ Treg and CD4+ CD25+ Foxp3+ Treg) and helper T cells(CD4+,CD8+ and CD4+/CD8+).Results:CD4 CD25+ Treg and CD4+ CD25+ Foxp3+ Treg expression level of peripheral blood in cold and heat type asthma group was significantly lower than that in the control group. At the same time, CD4 CD25+ Treg and CD4+ CD25+ Foxp3+ Treg expression level of peripheral blood in cold type asthma group was significantly lower than that in heat asthma group(P<0.05). CD4+ expression level of peripheral blood in cold and heat type asthma group was significantly higher than that in the control group, but CD8+ expression level and CD4+/CD8+ ratio of peripheral blood were significantly lower than those in the control group. At the same time, CD4+ and CD8+ expression level in cold type asthma  group was significantly lower than that in the heat type asthma group(P<0.05).Conclusion:Regulatory T cells and helper T cells of peripheral blood have abnormal expression in cold and heat type asthma children，and the abnormal expression becomes more obvious in the cold type asthma group. Related Articles | Metrics

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Observation on the effect of infantile massage as adjuvant treatment for infants with herpangina(solid-heat syndrome) JIA Guohua 2018, 10 (4):  343-345.  doi: 10.3969/j.issn.1674-3865.2018.04.021 Abstract ( 757 )   PDF (389KB) ( 152 )   Save Objective:To observe the clinical effect of infantile massage as adjuvant treatment for infants with herpangina(solid-heat syndrome).Methods:Totally 107 cases of herpangina were selected who were treated from October 2015 to February 2017 in the Outpatient Department of Pediatrics, Fuping County Hospital of Hebei Province. The patients were randomly divided into two groups:54 cases in the observation group and 53 cases in the control group. The control group was treated with intravenous dripping of ribavirin and energy drugs, and antipyretic drugs were used for fever above 38.5 ℃. The observation group was treated with massage therapy on the basis of the treatment for control group. After 4 days, the treatment effect and the time for clinical symptoms and signs to disappear before and after treatment were compared between the two groups.Results:The total effective rate of the observation group was 90.7% (49/54), which was significantly higher than that of the control group (75.5%,40/53), and the difference was statistically significant (P<0.05). The fever abatement time, saliva disappearance time and herpes disappearance time in the observation group were shorter than those in the control group, the difference being statistically significant (P<0.05).Conclusion:The clinical efficacy of infantile massage in the treatment of infantile herpangina is better, and the method is simple and easy to perform; it's more likely for the children and their families to accept. Related Articles | Metrics

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Effect of rigid bronchoscope and bronchial lavage on children with plant foreign body JING Yunlong 2018, 10 (4):  346-348.  doi: 10.3969/j.issn.1674-3865.2018.04.022 Abstract ( 823 )   PDF (393KB) ( 144 )   Save Objective:To explore the clinical effect of two methods in the treatment of bronchial plant foreign body in children: simple rigid bronchoscope and bronchoscopy combined with bronchial lavage.Methods:From October 2014 to December 2015, 79 children with bronchial plant foreign bodies treated in Hunan Children's Hospital were selected as the subjects. According to different clinical treatments, there were 40 cases in the observation group and 39 cases in the control group. The control group was treated with the removal under rigid bronchoscope, and the observation group was treated with bronchial lavage combined with bronchoscope. The time of disappearance of the main symptoms, the mean time of hospitalization and the clinical effect were observed and compared between the two groups.Results:The disappearance time of shortness of breath (or wheezing), cough and moist rales in the observation group was significantly shorter than that in the control group (P<0.05). The mean hospitalization time of the observation group was (4.15±1.41) days, which was significantly shorter than that of the control group (6.16±1.84) days, and the difference was statistically significant (P<0.05). The effective rate of the observation group was 75.0% (30/40), which was significantly higher than that of the control group (38.4% ,15/39), and the difference was statistically significant (P<0.05).Conclusion:The treatment for bronchial plant foreign bodies in children with rigid bronchoscope combined with bronchial lavage has good clinical effect; the clinical symptoms and signs of children disappear quickly, and the recovery process is short, so it's worth clinical application. Related Articles | Metrics

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Clinical features of 88 children with multiple resistant bacteria, its treatment strategy and the analysis of prognosis TIAN Maoqiang, LONG Lihua, REN Yang, DAI Jianrong 2018, 10 (4):  349-351.  doi: 10.3969/j.issn.1674-3865.2018.04.023 Abstract ( 752 )   PDF (369KB) ( 190 )   Save Objective:To explore the clinical features of hospitalized children with multiple resistant bacteria and summarize effective treatment strategies in order to provide reference for reasonable use of antibiotics.Methods:In the children hospitalized for treatment in Tongren People's Hospital from Jan. 2014 to Dec. 2016,there were 88 children with multidrug resistant bacteria infection. The clinical features of these children were comprehensively analyzed(including systematic inflammatory response, routine blood test, C-reactive protein and calcitonin). The treatment strategies and prognosis were also analyzed to decide whether the drugs used according to experience were adjusted to sensitive antibiotics. The children were divided into two groups: the adjusted antibiotic group(group A,17 cases) and the non adjusted antibiotic group(group B,71 cases).Results:The white blood cell count, neutrophil proportion, and calcitonin increased in group A, while C-reactive protein decreased, but there was no statistical difference in WBC count between group A and group B(P>0.05);there was statistical difference in neutrophil proportion, C-reactive protein and calcitonin between the two groups(P<0.05). The systematic inflammatory response was obvious in group A, but not obvious in group B. The cure rate of group B was 95.8%(68/71), which was higher than that of group A(76.5%,13/17). The mean length of hospital stay was (7.44±1.13)d in group B, shorter than that of group A［(10.22±2.53)d,P<0.05］.Conclusion:In clinical work, it is necessary to scientifically analyze the clinical features and monitoring results, make correspondent treatment strategies use antibiotics reasonably in order to guarantee the effect and safety of the treatment. Related Articles | Metrics

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Clinical analysis and follow-up of 84 children with myasthenia gravis CHEN Mei, FENG Mei, YANG Sai 2018, 10 (4):  352-354.  doi: 10.3969/j.issn.1674-3865.2018.04.024 Abstract ( 705 )   PDF (409KB) ( 283 )   Save Objective:To analyze the clinical characteristics of 84 children with myasthenia gravis and to make follow-up.Methods:From January 2012 to December 2014, 84 cases of myasthenia gravis in two Department of Neurology in Hunan Children's Hospital were collected as the research subjects, and the clinical data were analyzed in detail.Results:There were 66 cases(78.57%) of musculus-ocularis type(type Ⅰ) in 84 cases, 10 cases(11.90%) of systematic type(type Ⅱ), 5 cases(5.95%) of severe radical type(type Ⅲ), and 3 cases(3.57%) of late-severe type(type Ⅳ); 40 cases(47.62%) had onset before 3 years of age,25 cases between 3 and 7(29.76%) and 19 cases(22.62%) over 7 years old. There were 15 cases(17.86%) of upper respiratory tract infection before onset. During the follow-up period, 1 case who responded poorly to cyclophosphamide was sent to another hospital for treatment and died during follow-up. There were 44 cases of recurrence, 1~2 times of recurrence in 36 cases(81.82%), 3~5 times in 6 cases(13.64%), and over 5 times in 2 cases(4.55%). Hormone therapy was effective and 1 child died during the follow-up.Conclusion:Myasthenia gravis children are more of musculus-ocularis type, with lower mortality and better prognosis. Related Articles | Metrics

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Application of comfort nursing in the nursing of asthmatic children in acute attack QIAN Oujing 2018, 10 (4):  355-357.  doi: 10.3969/j.issn.1674-3865.2018.04.025 Abstract ( 594 )   PDF (437KB) ( 222 )   Save Objective:To study the application result of comfort nursing in the nursing of asthmatic children in acute attack.Methods:A total of 108 children with asthma were chosen as the research subjects, who were treated in Shenyang 245 Hospital from August 2015 to August 2016, and they were randomly divided into two groups: observation group and control group, 54 cases in each. Conventional nursing was performed for the children in both groups, and the children in observation group were also given comfort nursing. Compare the following items between the two groups: improvement in signs and symptoms, length of hospital stay, hospitalization cost, and satisfaction degree to the nursing.Results:In the observation group, the disappearance time of the children's signs and symptoms of moist rales, wheezing, dyspnea, cough and expectoration was significantly shorter, compared with that of the control group, and the difference was statistically significant (P<0.05). The mean hospitalization time of the children in the observation group was significantly shorter than that of the control group, and the hospitalization cost was significantly less than that of the control group, and the difference was statistically significant (P<0.05). The total satisfaction rate of nursing in the observation group was 94.44%(51/54), which was significantly higher than the control group 77.78%(42/54). The difference was statistically significant(P<0.05).Conclusion:Comfortable nursing in children with acute episode of asthma can help to relieve the symptoms and signs quickly, shorten hospitalization time, save the cost of hospitalization and improve the nursing satisfaction of children's family. Related Articles | Metrics

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Experience of modified Ophiopogon decoction in treating chronic cough in children PENG Minghao, SONG Guihua 2018, 10 (4):  358-360.  doi: 10.3969/j.issn.1674-3865.2018.04.026 Abstract ( 1303 )   PDF (441KB) ( 429 )   Save Ophiopogon decoction is from Synopsis of the Golden Chamber, and is mainly used in the treatment of deficiency-heat and lung-weakness syndrome. Prof. Song Guihua has her own features in treating children with chronic cough. She believes that this disease is with deficiency in origin and excess in superficiality, so Prof. Song performs the treatment based on wind, stasis and deficiency according to the children's physical characteristics and the clinical symptoms. The deficiency of lung and spleen is the origin, and wind and stasis are the superficiality. Therefore, modified ophiopogon decoction is often used in clinical treatment, which has achieved significant effect. Related Articles | Metrics

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Clinical experience of Professor YU Jian in treating GVHR after umbilical cord blood stem cell transplantation SUN Wen, YU Jian, ZHANG Feifei, SHI Yumin 2018, 10 (4):  360-362.  doi: 10.3969/j.issn.1674-3865.2018.04.027 Abstract ( 799 )   PDF (398KB) ( 129 )   Save For the children's rare diseases, umbilical cord blood stem cell transplantation (UCBT) can be used as a radical treatment program. However, graft versus host response (GVHR) is more common after UCBT. Based on the physiological characteristics of children, Professor Yu perform the treatment by replenishing and restoring Lung qi and supplementing spleen and kidney, which has achieved good clinical effect. A case is presented here. Related Articles | Metrics

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Analysis of the clinical experience in treating Henoch-Schonlein purpura nephritis based on stasis XU Shuang, REN Xianqing 2018, 10 (4):  363-356.  doi: 10.3969/j.issn.1674-3865.2018.04.028 Abstract ( 783 )   PDF (436KB) ( 95 )   Save Henoch-Schonlein purpura nephritis（HSPN）is a difficult clinical disease in pediatrics. Professor Ren Xianqing thinks that the main pathogenesis of HSPN is heat，deficiency and stasis，and stasis is the mostimportant one. The treatment of activating blood and removing stasis should be used through the course，which is on the basis of "clearing heat and dispersing wind，benefiting qi and tonifying yin". Clinically，he proposes that using TCM syndrome differentiation and paying attention to the treatment of activating blood and removing stasis during the course of clinical treatment can prevent renal injury. Besides，the combination of Tripterygium Glycosides tablet and Piperazine Ferulate tablets can be used as needed during the treatment to improve blood hypercoagulability，which has prominent curative effect. Related Articles | Metrics

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Practice and experience of diversified teaching methods in the teaching of Pediatrics of Integrated Chinese and Western Medicine LUO Yinhe, WANG Mengqing, JIANG Ping, XIE Jing, LI Lipeng 2018, 10 (4):  366-368.  doi: 10.3969/j.issn.1674-3865.2018.04.029 Abstract ( 887 )   PDF (422KB) ( 363 )   Save Under new situation of the reform and deepening of China's higher education, in order to achieve the goal of cultivating new applied talents and improve the students' practical ability, innovation ability and comprehensive quality, the author has practiced and explored diversified teaching methods in the teaching of Pediatrics of Integrated Chinese and Western Medicine on the basis of analyzing the relationship between teaching methods and teaching effects and the focus of the teaching of Pediatrics of Integrated Chinese and Western Medicine. Related Articles | Metrics