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Individualized intervention strategies in the treatment of childhood and adolescent obesity based on precision medicine LI Ping, YANG Fan, LIU Hanmin Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 1-7.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.001 Abstract （776）      PDF（pc） （1165KB）（1272）       Knowledge map    Save Childhood and adolescent obesity has become a global challenge in public health.Its high weight regain rate and risks of metabolic complications highlight the limitations of traditional intervention strategies.This review systematically explores individualized intervention strategies for obesity in children and adolescents in the context of precision medicine,breaking the traditional "one-size-fits-all" model.It integrates multi-omics technologies with intelligent management methods,proposing a multidimensional framework for precise intervention.First,a precise diagnosis and evaluation system is constructed based on multi-modal data,including genomics,radiomics,and gut microbiomics,to identify genetic susceptibility,metabolic phenotypes and microbiome characteristics,laying the foundation for stratified interventions.Secondly,individualized intervention plans are developed based on genetic risk scores,epigenetic regulatory mechanisms,and gut microbiome-targeted therapies:gene-guided strategies aim to optimize dietary structure through multi-gene risk assessments; epigenetic interventions aim to regulate DNA methylation and histone modification by taking advantage of nutrients (such as methyl donors and short-chain fatty acids),reversing metabolic dysregulation; microbiome remodeling aims to improve energy metabolism balance through probiotics and synbiotics.Furthermore,artificial intelligence and wearable devices are employed for dynamic monitoring in multiple scenarios.By collaborating with multidisciplinary teams in nutrition,sports medicine,and psychology,a smart management model of "hospital-family-community" network is established.While precision medicine offers groundbreaking directions for childhood obesity treatment,challenges such as biomarker validation,data integration,and long-term efficacy evaluation remain to be addressed.This review provides theoretical foundations and practical pathways for the improvement in the effectiveness and sustainability of interventions,emphasizing the need to integrate interdisciplinary innovative technologies in the future in order to promote the transformation of childhood obesity management toward precision and intelligence. Related Articles | Metrics

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Risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children:a systematic review and Meta-analysis LUO Zihao, GENG Gang, WANG Yanhong, LI Shaojun Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 500-508.   DOI: 10.3969/j.issn.1674-3865.2024.06.009 Abstract （660）      PDF（pc） （3957KB）（345）       Knowledge map    Save Objective:To systematically evaluate the risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.Methods:Computer retrieval was conducted in PubMed,Embase,Web of Science,Cochrane Library,CBM,Chinese Medical Journal Full-text Database,Wanfang Database,VIP and CNKI to collect related studies on risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.The retrieval period was from the establishment of the databases to February 2024.Meta-analysis was performed using Stata 18.0 and RevMan 5.4 software.Results:A total of 17 studies were included,all being case-control studies,involving 4 336 children.The results of Meta-analysis showed that fever duration［OR=4.45,95%CI(3.32-5.96),P<0.001］,C-reactive protein(CRP)［OR=1.45,95%CI(1.28-1.65),P<0.001］,D-dimer［OR=2.21,95%CI(1.27-3.85),P=0.005］,neutrophil ratio(N%)［OR=1.47,95%CI(1.17-1.85),P=0.001］,pleural effusion［OR=3.63,95%CI(2.77-4.76),P<0.001］,atelectasis［OR=4.03,95%CI(2.46-6.63),P<0.001］ and allergy history［OR=3.04,95%CI(2.39-3.78),P<0.001］ were positively correlated with Mycoplasma pneumoniae pneumonia complicated with plastic bronchitis in children,while lymphocyte ratio(L%)［OR=0.71,95%CI(0.52-0.96,P=0.030)］ was negatively correlated with it,and lactate dehydrogenase(LDH)［OR=1.02,95%CI(1.00-1.03),P=0.020］ was not an influencing factor for it.Conclusion:Current evidence shows that the longer the fever duration,the higher the proportion of CRP,D-dimer and neutrophils,and the lower the proportion of lymphocytes;combination with atelectasis,pleural effusion,and allergic history are risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children. Related Articles | Metrics

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Expert consensus on the diagnosis and treatment of pharyngitis and tonsillitis in children WANG Xuefeng, SHANG Yunxiao, XIONG Lei, ZHANG Jianhua, QIN Yanhong, LIU Changshan, ZHANG Baoqing, CAO Ling, XU Hua, WANG Lining, YANG Nan, LI Miao, YANG Yungang, ZHANG Xiuying Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 399-403.   DOI: 10.3969/j.issn.1674-3865.2024.05.009 Abstract （622）      PDF（pc） （1047KB）（410）       Knowledge map    Save Pharyngitis and tonsillitis are common respiratory infectious diseases in childhood,and are highly prevalent in spring and fall.They can be categorized into acute and chronic stages.The acute stage is characterized by rapid onset and progression of the disease,and in severe cases,hoarseness and even respiratory difficulties may occur.In the chronic stage,the disease is prolonged due to the lack of proper treatment.Repeated pharyngitis and tonsillitis can lead to voice changes in children.At present,there are not many western medicines that can effectively treat childhood pharyngitis and tonsillitis,which are mainly antibiotic drugs,and although there are many types of traditional Chinese medicines used to clear the throat,western pediatricians are not standardized in the selection,syndrome differentiation and application of traditional Chinese medicines.Therefore,it is particularly important to explore the treatment for pharyngitis and tonsillitis in children with integrated Chinese and western medicine.This consensus firstly systematizes the Chinese and western medical understanding of pharyngitis and tonsillitis in children;secondly,it discusses its staging,etiology and main risk factors;thirdly,it clarifies its diagnostic criteria;finally,it gives a detailed elaboration on the principle of integrated Chinese and western medicine treatment for pharyngitis and tonsillitis in children and the Chinese and western medicine treatment methods.This consensus provides Chinese and western pediatricians,especially western physicians,with ideas on integrated Chinese and western medicine treatment,and further standardizes the rational selection and application of Chinese and western medicines. Related Articles | Metrics

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Experience and reflection on traditional Chinese medicine treatment for precocious puberty in children and impaired height XIONG Lei, HE Xiying, CAO Ting Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 377-379.   DOI: 10.3969/j.issn.1674-3865.2024.05.003 Abstract （619）      PDF（pc） （1016KB）（642）       Knowledge map    Save The clinical manifestation of precocious puberty is the premature development of secondary sexual characteristics, which can cause increased growth rate, rapid skeletal maturation, premature epiphyseal closure, etc. If not treated in time, it may cause children to be short in adulthood and increase the risk of endocrine diseases. Gonadotrophin releasing hormone analogue is the first choice in the treatment of this disease in western medicine, which can significantly inhibit the sexual development process by regulating the hypothalamicpituitarygonadal axis, but there is still controversy in terms of benefits to children's height. Traditional Chinese medicine therapy has been proven to be safe and effective in improving children's symptoms, regulating sex hormone levels, delaying gonadal development, improving height impairment, and increasing adult height. Professor Xiong Lei believes that the core pathological mechanism of this disease is kidneyyin deficiency and hyperactivity of liveryang fire. The treatment should be nourishing yin to strengthen the root, and lowering fire to clear sources. At the same time, for the patients with stagnated heat of liver channel, the method of dispersing stagnatedliver qi and clearing fire is used; for those with internal retention of phlegmdampness, the method of invigorating spleen to dissipate phlegm is used; for those with disharmony in the middle jiao, the method of invigorating spleen and harmonizing stomach is used. For children with rapid progression, gonadotrophin releasing hormone analogue can be used at the same time; for children with growth retardation and height impairment, recombinant human growth hormone should be considered to maximize their benefits to the height. Related Articles | Metrics

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Studies on short stature in Chinese and western medicine and the prospects YU Jian, WANG Na Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 372-376.   DOI: 10.3969/j.issn.1674-3865.2024.05.002 Abstract （495）      PDF（pc） （1076KB）（565）       Knowledge map    Save Short stature is affected by many congenital and acquired environmental factors, which involves every stage from pregnancy to adolescence. From the perspective of integrated Chinese and western medicine, this article systematically summarizes the definition and epidemiological features of short stature in clinical practice, as well as its diagnosis and treatment strategies in Chinese and western medicine. It is emphasized that a comprehensive intervention should be performed in order to scientifically cope with the issues on children's growth and development, especially short stature, which includes life style adjustment, nutritional regulation, exercise and sleep management. Researches have shown that the integrated Chinese and western medicine therapy can not only increase the growth rate of children's height effectively, but also adjust the constitution of children in a comprehensive way, which improves the general health level of children. This article aims to provide theoretical support and practical reference for future clinical management of short stature and not-up-tostandard stature. Related Articles | Metrics

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Diagnosis and treatment guideline for functional dyspepsia in children with the integrated traditional Chinese and western medicine WANG Xuefeng, WU Jie, GONG Sitang, XIONG Lei, JIANG Mizu, WANG Baoxi, XU Hua, PENG Yu Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 461-468.   DOI: 10.3969/j.issn.1674-3865.2024.06.001 Abstract （490）      PDF（pc） （1049KB）（789）       Knowledge map    Save Functional dyspepsia,as one of the most common functional diseases of upper digestive tract,seriously affects the quality of life and growth and development of children in China.Due to the changing definition and symptom spectrum of functional dyspepsia in children,its diagnosis and treatment are controversial.In order to standardize the diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine,and effectively solve the clinical problems in the diagnosis and treatment of children with functional dyspepsia,this guideline is formulated to guide the standardized diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine. Related Articles | Metrics

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Treatment for childhood short stature based on "Yang transforming qi and yin shaping stature" TONG Tingting, ZHANG Guiju Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 392-394.   DOI: 10.3969/j.issn.1674-3865.2024.05.007 Abstract （412）      PDF（pc） （1048KB）（884）       Knowledge map    Save Childhood short stature is mostly caused by insufficient cong enital endowment and improper nutrition later on, and the key pathogenesis is the spleen and kidney insufficiency. At present, recombinant human growth hormones are used most often for the treatment of short stature in western medicine, and the treatment plan is relatively simple. Traditional Chinese medicine(TCM) has obvious effects in the treatment of short stature based on syndrome differentiation, which can effectively improve children's growth rate and regulate physical fitness. Based on the clinical experience of Professor Zhang Guiju and the theory of "Yang transforming qi and yin shaping stature" it is believed that childhood short stature is closely related to the insufficiency of "Yin shaping stature". Yin essence plays an important role in the growth and development of the human body. Children can gradually grow taller and stronger if the function of "Yin shaping stature" is normal. On the contrary, insufficiency in "Yin shaping stature" will lead to delayed growth and short stature in children. Therefore, in the treatment of childhood short stature, it is necessary to add yin-nourishing Chinese medicines based on syndrome differentiation, such as Radix rehmanniae praeparata, Cornus officina, yam, Fructus lycii, Polygonatum kingianum, Polygonatum odoratum, lily, etc. Such medicines contain a variety of effective ingredients, which can not only supplement the nutrients needed by the human body, but also have a variety of effects such as regulating immunity and protecting the internal organs. In addition, spleen-strengthening and digestion-assisting drugs should be added to the prescription to protect the spleen and stomach and prevent getting too greasy. Related Articles | Metrics

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Application of external treatment of Chinese medicine in children's growth and development WANG Lining, SUN Kexing, LIANG Yi Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 384-387.   DOI: 10.3969/j.issn.1674-3865.2024.05.005 Abstract （394）      PDF（pc） （1006KB）（564）       Knowledge map    Save Short stature and not-up-to-standard stature belong to the category of "Wu Chi" and "Wu Ruan" in Chinese medicine, and Chinese medicine believes that the pathogenesis of them is deficiency in the spleen and kidney, which gets the heart and liver involved. External treatment of Chinese medicine is a unique natural and green therapy under the guidance of Chinese medicine theory, which has certain advantages in the treatment of short stature and not-up-to-standard stature. This article summarizes the treatment methods such as massage, acupuncture, moxibustion and acupoint application, as well as the mechanism of external treatment of Chinese medicine for children with short stature and not-up-to-standard stature, with a view to guide the early and timely clinical intervention, improve the function of children's internal organs and promote their growth and development. Related Articles | Metrics

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Traditional Chinese medicine understanding of short stature in children and syndrome differentiation and treatment for the disease WANG Xuefeng, ZHANG Xiuying Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 380-383.   DOI: 10.3969/j.issn.1674-3865.2024.05.004 Abstract （390）      PDF（pc） （1026KB）（746）       Knowledge map    Save Because children with short stature are shorter than children of the same age,they may suffer from low self-esteem,which seriously affects their mental health and has different degrees of impact on their future learning and lives.Traditional Chinese medicine has some advantages in the treatment of this disease because its syndrome differentiation and treatment can improve the growth and development of children.This paper first sorts out the historical development of short stature,which,as an independent name of the disease,was firstly seen in the textbook of Integrated Traditional Chinese and Western Medicine Pediatrics edited by Prof.Wang Xuefeng.Then,the etiology and mechanism of short stature are summarized.Its etiology is the deficiency of innate endowment and the lack of nutrition in later life.The disease is located in the spleen and kidneys,and it is closely related to the heart,liver and lungs. The nature of the disease is mostly deficiency.The primary mechanism of the disease is the deficiency of the five organs and the deficiency of essence and qi.The basic treatment principle is determined again,which is to support the spleen and nourish kidneys and also to take into account other organs.Among the treatment methods,the method of tonifying the kidneys and nourishing the liver is suitable to those with deficiency of yin in the liver and kidneys and loss of nourishment of the muscles and bones;the method of supporting the spleen and strengthening the stomach is suitable to those with weakness of the spleen and stomach and deficiency of qi and blood;the method of nourishing the kidneys and clearing the heart is suitable to those with deficiency of the heart and kidneys and imbalance of water and fire;the method of strengthening the spleen and nourishing the lungs is suitable to those with deficiency in the lungs and spleen and loss of qi of the mother;the method of warming and tonifying the kidney-yang is suitable to those with insufficiency of the kidney-yang and dysfunction of warming.Finally,the strategy of multi-dimensional care and prevention before the onset of disease is put forward.For children with short stature,attention should be paid to balanced nutrition,moderate increase in exercise,reasonable arrangement of sleep,and adjustment of the body in line with the four seasons. Related Articles | Metrics

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Rehabilitation evaluation and treatment progress of hypotonia in infants and young children XU Haofan, ZHONG Zengquan, LAI Yanmei, LI Wei, ZHANG Xin, LI Hong, YANG Fan, LI Yiming, LYU Zhihai Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 414-419.   DOI: 10.3969/j.issn.1674-3865.2024.05.012 Abstract （360）      PDF（pc） （1091KB）（612）       Knowledge map    Save Hypomyotonia accompanied by growth retardation is an early symptom and sensitive sign of global developmental delay(GDD) in infants and young children,and is one of the early clinical manifestations of neurodevelopmental disorders and genetic metabolic diseases,which has a high incidence rate.According to the location of neuromuscular damage and involvement,hypotonia can be divided into three types:central hypotonia(CH),peripheral hypotonia(PH),or mixed hypotonia(MH).On the basis of etiological diagnosis of hypotonia,clinical evaluation and rehabilitation evaluation are conducted.Rehabilitation evaluation includes assessment of motor development level,developmental evaluation,evaluation of communication ability,and evaluation of daily life activity ability.Under the theoretical framework of the international classification of functioning,disability,and health(children and youth edition)(ICF-CY),the methods such as exercise therapy,traditional Chinese medicine rehabilitation,neuromuscular electrical stimulation,intramuscular patches,and assistant braces are adopted to promote the development of anti-gravity postures.Based on function-orientation and with the goal being to continuously improve activity and participation abilities,environmental factors such as rehabilitation aids are used to modify and improve the ability of daily life activities. Related Articles | Metrics

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Research progress of neurotransmitter imbalance in tic disorders JIANG Ling, ZHANG Di, LlU Ying Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 132-136.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.007 Abstract （358）      PDF（pc） （1040KB）（671）       Knowledge map    Save Tic disorder(TD) is a neuropsychiatric disorder,the exact causes and mechanisms of which are not yet fully understood.In recent years,the prevalence of tic disorder has been on the rise.Patients with TD often present with comorbidities such as attention deficit hyperactivity disorder,obsessive compulsive disorder,learning difficulties,anxiety,and depression.These issues not only negatively impact children's academic performance but may also bring great trouble to their growth,development,and mental health.Researches have indicated that the occurrence of TD is closely related to various factors,including neurotransmitter imbalance,genetic factors,psychosocial factors,and infections or immune factors.Neurotransmitters play a crucial role in maintaining normal function of nervous system,and in TD patients,there may be neurotransmitter imbalance,which affects their behavior and cognitive functions.In depth research in the pathogenesis of TD,especially in neurotransmitter imbalance,helps us better understand its pathological processes and provides new therapeutic approaches and strategies for controlling its symptoms.Through targeted treatment and interventions,symptoms can be effectively alleviated,which helps patients improve their quality of life and reduce the negative impact on society and families.This article mainly reviews the relationship between neurotransmitter imbalance and the development of tic disorder. Related Articles | Metrics

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Meta-analysis of traditional Chinese medicine combined with recombinant human growth hormone in the treatment of children with idiopathic short stature WU Yishi, ZHANG Xiuying, LI Zhaoyang, WANG Xuefeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 425-430.   DOI: 10.3969/j.issn.1674-3865.2024.05.014 Abstract （348）      PDF（pc） （2283KB）（445）       Knowledge map    Save Objective：To systematically assess the clinical efficacy of traditional Chinese medicine in conjunction with recombinant human growth hormone, as well as that of recombinant human growth hormone alone, in the treatment of children with idiopathic short stature, thereby providing an evidence-based reference for clinical treatment. Methods：CNKI, VIP, Wanfang, CBM, and Pubmed were searched for literature that met the inclusion and exclusion criteria from the establishment of the database to September 30, 2024. RevMan 5.4 software was used for statistical analysis.Results：A total of 19 randomized controlled clinical trials with 1 756 patients were included, including 873 cases in the observation group and 883 cases in the control group. The results of Meta-analysis showed that the application of traditional Chinese medicine combined with recombinant human growth hormone in the treatment of idiopathic short stature was significantly better than the simple application of recombinant human growth hormone in improving the total effective rate, height, weight, growth rate, insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels, and the incidence of adverse reactions was lower than the simple application of recombinant human growth hormone.Conclusion：The integration of traditional Chinese medicine with recombinant human growth hormone demonstrates significant efficacy in the treatment of children with idiopathic short stature. Related Articles | Metrics

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Research progress on external treatment of traditional Chinese medicine for children with sleep disorders LIU Wen, GUAN Lijun Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 410-413.   DOI: 10.3969/j.issn.1674-3865.2024.05.011 Abstract （345）      PDF（pc） （1030KB）（638）       Knowledge map    Save Sleep disorders have gradually become one of the common diseases in children,and sleep quality is very important for children′s growth and development.Traditional Chinese medicine has achieved remarkable results in the treatment of sleep disorders in children.Because of its safety,reliability,having no adverse reactions and simple operation,TCM external treatment is easy to be accepted by parents.This paper systematically sorts out the commonly used external treatment methods of Chinese medicine for children with sleep disorders,including acupuncture,acupoint application,massage and transcranial magnetic therapy,etc.,and summarizes and studies the relevant literature of these methods. Related Articles | Metrics

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Paying attention to the standardized diagnosis and treatment for children with short stature LUO Xiaoping, WU Wei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 369-371.   DOI: 10.3969/j.issn.1674-3865.2024.05.001 Abstract （342）      PDF（pc） （1010KB）（585）       Knowledge map    Save Short stature has a significant impact on the physical and mental health of children, and it is a common disease in the endocrine department of pediatrics. Due to the rapid changes in children's growth and development and the complex etiology of short stature, there have always been such issues as missed diagnoses, misdiagnoses and insufficient intervention or overtreatment. This necessitates the strengthening of standardized diagnosis and treatment. This article discusses the challenges faced in the clinical diagnosis and treatment of children with short stature, especially emphasizing two aspects: one is to find out the etiology and make precise diagnosis, and the other is to perform individualized treatment strictly based on the indications. Meanwhile, the future direction of diagnosis and treatment of short stature is prospected, and suggestions are put forward for further standardization of diagnosis and treatment behavior of short stature, in order to provide useful reference for clinicians and policy makers. Related Articles | Metrics

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Discussion on the influence of Wan Quan′s "Four methods of infant rearing" on the growth and development of children FENG Zhongfa, YANG Jianhui, SU Yanyan, WEI Jiaxuan, TAO Qiong, DU Li Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 395-398.   DOI: 10.3969/j.issn.1674-3865.2024.05.008 Abstract （334）      PDF（pc） （1050KB）（818）       Knowledge map    Save Wan Quan has proposed the "Four methods of infant rearing":pre-raising to cultivate origin,fetal raising to ensure health,peripartum raising to prevent changes,and postpartum raising to be alert to diseases-The method of pre-raising to cultivate origin involves preparing for pregnancy,avoiding harm,and ensuring a healthy birth-The method of fetal raising to ensure health means that parents should focus on mental adjustment,moral cultivation,diet and daily habits,exercise,and fetal education to ensure the healthy development of the fetus-The method of peripartum raising to prevent changes includes care for the child,disease prevention and control,and care for the mother′s body from the neonatal period to the infant period-The method of postpartum raising to be alert to diseases includes daily care,diet and nutrition,disease prevention,and early education from early childhood to the early school age-Fully exploring the implications of Wan Quan′s "Four methods of infant rearing" theory and connecting it with the growth and development of children has certain referential significance for the upbringing of children today Related Articles | Metrics

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Effect of Chiqiao Qingre granules combined with cefuroxime in the treatment of acute respiratory tract infection in children and its influence on inflammatory factors MA Xiaodan, GAO Wenli, WANG Jiaojiao Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 444-448.   DOI: 10.3969/j.issn.1674-3865.2024.05.018 Abstract （322）      PDF（pc） （1066KB）（199）       Knowledge map    Save Objective：To explore the effect of Chiqiao Qingre granules combined with cefuroxime in the treatment of acute respiratory tract infection(ARTI) in children and its influence on inflammatory factors.Methods：A total of 103 children with ARTI admitted to our hospital from March 2021 to March 2023 were selected and divided into observation group(treated with Chiqiao Qingre granules combined with cefuroxime,n=52) and control group(treated with cefuroxime,n=51) according to different treatment methods.The clinical curative effect and symptom disappearance time of the two groups were observed,and the inflammatory factors,immune function and the incidence of adverse reactions of the two groups were compared.Results：After treatment,the total effective rate of the observation group was 90.4%(47/52),significantly higher than that of the control group(70.6%,36/51)(P<0.05).Compared with the control group,the disappearance time of fever and other symptoms,such as cough,dry throat,running nose and chest pain,in the observation group was significantly shorter(P<0.05).The levels of serum interleukin-6(IL-6),serum amyloid A(SAA),C-reactive protein(CRP) and procalcitonin(PCT) in the two groups were reduced,and the level in the observation group was lower than that in the control group(P<0.05).The Th1 and Th1/Th2 in the two groups were increased,and the Th1/Th2 in the observation group was higher than that in the control group(P<0.05).The Th2 in both groups was decreased,and the Th2 in the observation group was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion：Chiqiao Qingre granules combined with cefuroxime is more effective in treating ARTI in children,which can speed up the disappearance of symptoms,relieve the body′s inflammatory response,and maintain immune balance,and it is safe and reliable. Related Articles | Metrics

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Current research status of the influence of dietary patterns on precocious puberty in children LIU Ziqi, ZHANG Guiju Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 17-22.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.004 Abstract （308）      PDF（pc） （1129KB）（667）       Knowledge map    Save When children enter puberty,they will experience prominent changes mainly in the morphology of their reproductive organs,and development of function and secondary sexual characteristics.The main manifestation of precocious puberty is the earlier development of secondary sexual characteristics and the premature maturation of sexual organs,which is an endocrine disease characterized by abnormal growth and development of children.With the development of economy and society,the advancement of the onset age of precocious puberty and the increase in incidence rate have triggered increasing social attention.Multiple factors can have an impact on precocious puberty,and modern researches have confirmed a correlation between the daily diet of children before puberty and precocious puberty.This article reviews domestic and foreign researches in common dietary patterns and various dietary nutrients related to adolescent sexual development in children,represented by high calorie diet patterns,Mediterranean diet patterns,and vegetarian diet patterns,and it summarizes the influence of different dietary patterns on precocious puberty in children.The article respectively summarizes the potential regulatory mechanisms of high protein diet,high-fat diet and high sugar diet in high calorie diet patterns,as well as the main dietary components (vegetables,fruits,olive oil,grains,nuts,beans,and dairy products) in Mediterranean diet patterns and vegetarian diet patterns in sexual development.The aim is to provide theoretical basis for the prevention and treatment of precocious puberty in children from the perspective of dietary intervention,and to provide new ideas for future researches on the relationship between dietary nutrition structure and sexual development. Related Articles | Metrics

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Effect of Jingling oral liquid on memory function in rats of ADHD animal model LIU Liwei, CHENG Shen, YANG Yufang, CHEN Jian, CHEN Yuyan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 27-32.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.006 Abstract （297）      PDF（pc） （1379KB）（223）       Knowledge map    Save Objective To explore the effect of Jingling oral liquid on improving memory function and promoting myelination in young spontaneously hypertensive rats (SHR) of ADHD animal model.Methods A total of 24 SHR were randomly divided into model group,tomoxetine group,Jingling oral liquid equal-dose group［11.15 g/（kg·d)］ and high-dose group［29.5 g/（kg·d)］,with 6 rats in each group,and 6 Wistar Kyoto rats (WKY) were included as control group.The improvement in working memory of the rats was observed by water maze after 6 weeks of treatment.The prefrontal lobes of the rats in each group were separated,and the structures of myelin sheath were observed by luxol fast blue（LFB）.The expressions of Nogo-A,MRF,FGF17,NG2 and MBP in the frontal lobe of rats were determined by western blot.Results （1） After 6 weeks of treatment,compared with the tomoxetine group,both the Jingling oral liquid equal-dose group and high-dose group demonstrated a more stable promotion of body weight gain in rats.（2）Compared with the model group,the finding time in water maze of SHR in tomoxetine group and Jingling equal-dose and high-dose groups was shortened after 6 weeks of treatment.（3） Compared with model group,myelin in brain tissues of rats in equal-dose and high-dose groups was tightly arranged with intact structure(P<0.05).（4） Compared with model group, NG2 and MRF protein expressions were increased in both Jingling oral liquid  equal-dose group and high-dose group，MBP expression was elevated in the high-dose group, while the FGF17 expression decreased in the equal dose-group, with all differences being statistically significant (P<0.05).Conclusion Jingling oral liquid can improve the memory and learning ability of SHR,and promote myelin regeneration and maturation. Related Articles | Metrics

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An analysis of Professor Qin Yanhong′s experience in treating children with cough-variant asthma ZHANG Minjie, QIN Yanhong, ZHANG Sufeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 455-457.   DOI: 10.3969/j.issn.1674-3865.2024.05.020 Abstract （296）      PDF（pc） （1030KB）（212）       Knowledge map    Save Cough-variant asthma(CVA) is a common and frequently occurring respiratory disease in children.In recent years,with the aggravation of air pollution,the change in living habits and the increase in social pressure,the number of CVA cases in children is increasing year by year,which has a great impact on the physical and mental development of children and their social activities.Modern medicine is effective in treating CVA,but the treatment course is long and the compliance of children is low,which significantly increases the side effects.Traditional Chinese medicine treatment has the obvious advantages of definite curative effect and few side effects.Professor Qin Yanhong believes that the occurrence of CVA is the result of internal and external causes:the external evil is dominated by wind evil,and the internal cause is often the deficiency of lung and spleen in children.The key pathogenesis is the internal accumulation of wind sputum and the upward reversal of lung qi,and the pathological factors are mainly wind,sputum and qi,so the treatment emphasizes on dispersing wind,eliminating phlegm and regulating qi,and the self-designed "Zhike decoction" with modification is used to treat the disease.Due to the long course of CVA disease,and because the pathological focus of different periods is different,the treatment by stage is emphasized in clinical practice,the main treatment is to remove the evil during the attack period and to reinforce the deficiency and remove the evil during the recovery period.The effect is significant,and it is well recognized by parents. Related Articles | Metrics

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Research progress in causes of premature puberty in traditional Chinese and western medicine LIU Qiannan, WANG Yanchao, MIAO Yizhuo, LI Lan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 13-16.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.003 Abstract （293）      PDF（pc） （1085KB）（403）       Knowledge map    Save Since the 1970s,it has been believed in traditional Chinese medicine (TCM) that the pathogenesis of precocious puberty is primarily associated with yin-deficiency and fire-excess,and the treatments that nourish yin and purge fire are advocated.Therefore,an integrated treatment strategy combining TCM and western medicine has gradually been formulated.Modern medical research indicates that precocious puberty results from the interplay of genetic and environmental factors,involving heredity,diet,chemical substance interference,and psychological factors.TCM emphasizes the combined influence of internal and external factors,such as dietary irregularities and emotional disturbances,and focuses on therapeutic methods like nourishing yin,purging fire,soothing the liver,and relieving stagnation.The integrated approach of TCM and western medicine offers a more comprehensive treatment plan for precocious puberty.The TCM theory of "preventive treatment of disease" underscores the importance of prevention,reducing risk factors and performing proactive treatment to avoid long-term complications. Related Articles | Metrics