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Individualized intervention strategies in the treatment of childhood and adolescent obesity based on precision medicine LI Ping, YANG Fan, LIU Hanmin Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 1-7.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.001 Abstract （979）      PDF（pc） （1165KB）（1405）       Knowledge map    Save Childhood and adolescent obesity has become a global challenge in public health.Its high weight regain rate and risks of metabolic complications highlight the limitations of traditional intervention strategies.This review systematically explores individualized intervention strategies for obesity in children and adolescents in the context of precision medicine,breaking the traditional "one-size-fits-all" model.It integrates multi-omics technologies with intelligent management methods,proposing a multidimensional framework for precise intervention.First,a precise diagnosis and evaluation system is constructed based on multi-modal data,including genomics,radiomics,and gut microbiomics,to identify genetic susceptibility,metabolic phenotypes and microbiome characteristics,laying the foundation for stratified interventions.Secondly,individualized intervention plans are developed based on genetic risk scores,epigenetic regulatory mechanisms,and gut microbiome-targeted therapies:gene-guided strategies aim to optimize dietary structure through multi-gene risk assessments; epigenetic interventions aim to regulate DNA methylation and histone modification by taking advantage of nutrients (such as methyl donors and short-chain fatty acids),reversing metabolic dysregulation; microbiome remodeling aims to improve energy metabolism balance through probiotics and synbiotics.Furthermore,artificial intelligence and wearable devices are employed for dynamic monitoring in multiple scenarios.By collaborating with multidisciplinary teams in nutrition,sports medicine,and psychology,a smart management model of "hospital-family-community" network is established.While precision medicine offers groundbreaking directions for childhood obesity treatment,challenges such as biomarker validation,data integration,and long-term efficacy evaluation remain to be addressed.This review provides theoretical foundations and practical pathways for the improvement in the effectiveness and sustainability of interventions,emphasizing the need to integrate interdisciplinary innovative technologies in the future in order to promote the transformation of childhood obesity management toward precision and intelligence. Related Articles | Metrics

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Diagnosis and treatment guideline for functional dyspepsia in children with the integrated traditional Chinese and western medicine WANG Xuefeng, WU Jie, GONG Sitang, XIONG Lei, JIANG Mizu, WANG Baoxi, XU Hua, PENG Yu Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 461-468.   DOI: 10.3969/j.issn.1674-3865.2024.06.001 Abstract （718）      PDF（pc） （1049KB）（802）       Knowledge map    Save Functional dyspepsia,as one of the most common functional diseases of upper digestive tract,seriously affects the quality of life and growth and development of children in China.Due to the changing definition and symptom spectrum of functional dyspepsia in children,its diagnosis and treatment are controversial.In order to standardize the diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine,and effectively solve the clinical problems in the diagnosis and treatment of children with functional dyspepsia,this guideline is formulated to guide the standardized diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine. Related Articles | Metrics

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Risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children:a systematic review and Meta-analysis LUO Zihao, GENG Gang, WANG Yanhong, LI Shaojun Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 500-508.   DOI: 10.3969/j.issn.1674-3865.2024.06.009 Abstract （708）      PDF（pc） （3957KB）（355）       Knowledge map    Save Objective:To systematically evaluate the risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.Methods:Computer retrieval was conducted in PubMed,Embase,Web of Science,Cochrane Library,CBM,Chinese Medical Journal Full-text Database,Wanfang Database,VIP and CNKI to collect related studies on risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.The retrieval period was from the establishment of the databases to February 2024.Meta-analysis was performed using Stata 18.0 and RevMan 5.4 software.Results:A total of 17 studies were included,all being case-control studies,involving 4 336 children.The results of Meta-analysis showed that fever duration［OR=4.45,95%CI(3.32-5.96),P<0.001］,C-reactive protein(CRP)［OR=1.45,95%CI(1.28-1.65),P<0.001］,D-dimer［OR=2.21,95%CI(1.27-3.85),P=0.005］,neutrophil ratio(N%)［OR=1.47,95%CI(1.17-1.85),P=0.001］,pleural effusion［OR=3.63,95%CI(2.77-4.76),P<0.001］,atelectasis［OR=4.03,95%CI(2.46-6.63),P<0.001］ and allergy history［OR=3.04,95%CI(2.39-3.78),P<0.001］ were positively correlated with Mycoplasma pneumoniae pneumonia complicated with plastic bronchitis in children,while lymphocyte ratio(L%)［OR=0.71,95%CI(0.52-0.96,P=0.030)］ was negatively correlated with it,and lactate dehydrogenase(LDH)［OR=1.02,95%CI(1.00-1.03),P=0.020］ was not an influencing factor for it.Conclusion:Current evidence shows that the longer the fever duration,the higher the proportion of CRP,D-dimer and neutrophils,and the lower the proportion of lymphocytes;combination with atelectasis,pleural effusion,and allergic history are risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children. Related Articles | Metrics

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Exploring the pathogenesis of pediatric functional dyspepsia based on the theory of "spleen deficiency as the root" WANG Na, LIU Shiyu, LIU Jie, YU Jian, XIONG Lei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 477-481.   DOI: 10.3969/j.issn.1674-3865.2024.06.004 Abstract （425）      PDF（pc） （1035KB）（524）       Knowledge map    Save Functional dyspepsia(FD) is a common chronic gastrointestinal disorder in children,characterized by symptoms such as upper abdominal discomfort,abdominal distension,poor appetite,and acid regurgitation.The pathogenesis of FD is complex,involving multiple factors such as gastrointestinal motility disorders,visceral hypersensitivity,and brain-gut axis dysfunction.In traditional Chinese medicine (TCM),it is believed that the theory of "spleen deficiency as the root" is the core pathological mechanism.Specifically,spleen deficiency impairs the normal flow of qi,leading to the accumulation of dampness and stagnation,which brings about gastrointestinal motility issues and visceral hypersensitivity.Furthermore,spleen dysfunction weakens qi and hinders digestive absorption and blood production,worsening gut microbiota imbalances and disrupting brain-gut axis regulation.The TCM treatment strategy for FD involves four key approaches:strengthening the spleen,regulating spleen qi,activating spleen function,and balancing qi flow.Strengthening the spleen and eliminating dampness enhances gastrointestinal motility and removes stagnation.Regulating spleen qi improves digestion and relieves food retention.Activating spleen function restores healthy digestion and absorption.Balancing qi flow ensures smooth coordination of qi ascending and descending to relieve stagnation.These TCM methods align closely with modern medical strategies of regulating gastrointestinal motility,reducing visceral hypersensitivity,and balancing brain-gut axis.This study systematically explores the pathogenesis of FD and the treatment strategy of integrating TCM with modern medicine from the perspective of "spleen deficiency as the root".It highlights the intricate interactions among spleen function,the brain-gut axis,and gut microbiota.This research provides theoretical foundation and guidance for the treatment of children with FD. Related Articles | Metrics

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Research progress of neurotransmitter imbalance in tic disorders JIANG Ling, ZHANG Di, LlU Ying Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 132-136.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.007 Abstract （400）      PDF（pc） （1040KB）（684）       Knowledge map    Save Tic disorder(TD) is a neuropsychiatric disorder,the exact causes and mechanisms of which are not yet fully understood.In recent years,the prevalence of tic disorder has been on the rise.Patients with TD often present with comorbidities such as attention deficit hyperactivity disorder,obsessive compulsive disorder,learning difficulties,anxiety,and depression.These issues not only negatively impact children's academic performance but may also bring great trouble to their growth,development,and mental health.Researches have indicated that the occurrence of TD is closely related to various factors,including neurotransmitter imbalance,genetic factors,psychosocial factors,and infections or immune factors.Neurotransmitters play a crucial role in maintaining normal function of nervous system,and in TD patients,there may be neurotransmitter imbalance,which affects their behavior and cognitive functions.In depth research in the pathogenesis of TD,especially in neurotransmitter imbalance,helps us better understand its pathological processes and provides new therapeutic approaches and strategies for controlling its symptoms.Through targeted treatment and interventions,symptoms can be effectively alleviated,which helps patients improve their quality of life and reduce the negative impact on society and families.This article mainly reviews the relationship between neurotransmitter imbalance and the development of tic disorder. Related Articles | Metrics

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Research progress in causes of premature puberty in traditional Chinese and western medicine LIU Qiannan, WANG Yanchao, MIAO Yizhuo, LI Lan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 13-16.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.003 Abstract （368）      PDF（pc） （1085KB）（419）       Knowledge map    Save Since the 1970s,it has been believed in traditional Chinese medicine (TCM) that the pathogenesis of precocious puberty is primarily associated with yin-deficiency and fire-excess,and the treatments that nourish yin and purge fire are advocated.Therefore,an integrated treatment strategy combining TCM and western medicine has gradually been formulated.Modern medical research indicates that precocious puberty results from the interplay of genetic and environmental factors,involving heredity,diet,chemical substance interference,and psychological factors.TCM emphasizes the combined influence of internal and external factors,such as dietary irregularities and emotional disturbances,and focuses on therapeutic methods like nourishing yin,purging fire,soothing the liver,and relieving stagnation.The integrated approach of TCM and western medicine offers a more comprehensive treatment plan for precocious puberty.The TCM theory of "preventive treatment of disease" underscores the importance of prevention,reducing risk factors and performing proactive treatment to avoid long-term complications. Related Articles | Metrics

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Current research status of the influence of dietary patterns on precocious puberty in children LIU Ziqi, ZHANG Guiju Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 17-22.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.004 Abstract （346）      PDF（pc） （1129KB）（837）       Knowledge map    Save When children enter puberty,they will experience prominent changes mainly in the morphology of their reproductive organs,and development of function and secondary sexual characteristics.The main manifestation of precocious puberty is the earlier development of secondary sexual characteristics and the premature maturation of sexual organs,which is an endocrine disease characterized by abnormal growth and development of children.With the development of economy and society,the advancement of the onset age of precocious puberty and the increase in incidence rate have triggered increasing social attention.Multiple factors can have an impact on precocious puberty,and modern researches have confirmed a correlation between the daily diet of children before puberty and precocious puberty.This article reviews domestic and foreign researches in common dietary patterns and various dietary nutrients related to adolescent sexual development in children,represented by high calorie diet patterns,Mediterranean diet patterns,and vegetarian diet patterns,and it summarizes the influence of different dietary patterns on precocious puberty in children.The article respectively summarizes the potential regulatory mechanisms of high protein diet,high-fat diet and high sugar diet in high calorie diet patterns,as well as the main dietary components (vegetables,fruits,olive oil,grains,nuts,beans,and dairy products) in Mediterranean diet patterns and vegetarian diet patterns in sexual development.The aim is to provide theoretical basis for the prevention and treatment of precocious puberty in children from the perspective of dietary intervention,and to provide new ideas for future researches on the relationship between dietary nutrition structure and sexual development. Related Articles | Metrics

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Effect of Jingling oral liquid on memory function in rats of ADHD animal model LIU Liwei, CHENG Shen, YANG Yufang, CHEN Jian, CHEN Yuyan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 27-32.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.006 Abstract （344）      PDF（pc） （1379KB）（231）       Knowledge map    Save Objective To explore the effect of Jingling oral liquid on improving memory function and promoting myelination in young spontaneously hypertensive rats (SHR) of ADHD animal model.Methods A total of 24 SHR were randomly divided into model group,tomoxetine group,Jingling oral liquid equal-dose group［11.15 g/（kg·d)］ and high-dose group［29.5 g/（kg·d)］,with 6 rats in each group,and 6 Wistar Kyoto rats (WKY) were included as control group.The improvement in working memory of the rats was observed by water maze after 6 weeks of treatment.The prefrontal lobes of the rats in each group were separated,and the structures of myelin sheath were observed by luxol fast blue（LFB）.The expressions of Nogo-A,MRF,FGF17,NG2 and MBP in the frontal lobe of rats were determined by western blot.Results （1） After 6 weeks of treatment,compared with the tomoxetine group,both the Jingling oral liquid equal-dose group and high-dose group demonstrated a more stable promotion of body weight gain in rats.（2）Compared with the model group,the finding time in water maze of SHR in tomoxetine group and Jingling equal-dose and high-dose groups was shortened after 6 weeks of treatment.（3） Compared with model group,myelin in brain tissues of rats in equal-dose and high-dose groups was tightly arranged with intact structure(P<0.05).（4） Compared with model group, NG2 and MRF protein expressions were increased in both Jingling oral liquid  equal-dose group and high-dose group，MBP expression was elevated in the high-dose group, while the FGF17 expression decreased in the equal dose-group, with all differences being statistically significant (P<0.05).Conclusion Jingling oral liquid can improve the memory and learning ability of SHR,and promote myelin regeneration and maturation. Related Articles | Metrics

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Analysis of the current status of clinical practice guidelines and diagnosis and treatment norms for children with pneumonia in recent 20 years WANG Bo, XIONG Lei, WANG Ziwei, BIAN Ji, YANG Shaoying, HE Xiying, MING Xi Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 39-44.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.008 Abstract （341）      PDF（pc） （1291KB）（446）       Knowledge map    Save By searching CNKI, China biomedical literature service system, Wanfang data knowledge service platform, Weipu Chinese science and technology journal full-text database, Pubmed, Embase and other databases, as well as Yimaitong, NICE,NGC,GIN and other websites, clinical practice guidelines and diagnosis and treatment norms for pediatric pneumonia were sorted out, and literature was independently screened by researchers. After extracting the data, the AGREE Ⅱ tool is used to evaluate the quality of the formulation methodology of the guidelines and diagnosis and treatment norms, and the recommended level is obtained, in order to grasp the formulation methods and quality status of clinical practice guidelines for childhood pneumonia at home and abroad, and to provide reference for the future formulation of high-quality clinical practice guidelines in professional fields. Related Articles | Metrics

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Research on the clinical application of Zhimu-Huangbai in precocious puberty CHEN Na, LI Lianke, LU Yihong, YANG Yang, TAO Qiong, CHEN Zhu Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 8-12.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.002 Abstract （311）      PDF（pc） （1083KB）（483）       Knowledge map    Save Zhimu-Huangbai is a commonly used medicine pair in clinical practice,and the compatibility of the two drugs has the effects of nourishing yin and clearing heat,purging fire and detoxifying.Modern studies have found that Zhimu-Huangbai has anti-inflammatory,antioxidant,hypoglycemic,and lipidemic regulation effects because of its main active ingredients such as quercetin,kaempferol,barmatine,stigmasterol,mangiferin,berberine,etc.It is widely used in clinical practice,mainly for the treatment of precocious puberty,diabetes,diabetic nephropathy and other diseases in children.From the perspectives of chemical composition,pharmacological effects and clinical application,this paper expounds the application research of Zhimu-Huangbai in precocious puberty in recent years,in order to provide a theoretical basis for the scientific application of the drug in precocious puberty and for the research and development of new drugs. Related Articles | Metrics

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Research advances in the treatment of neurodevelopmental disorders in children with fecal microbiota transplantation HUA Zhichao, CHEN Yuyan, YANG Yufang, CHEN Xiaoling Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 22-26.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.005 Abstract （308）      PDF（pc） （1122KB）（546）       Knowledge map    Save Fecal microbiota transplantation (FMT), as a method to treat intestinal and extra-intestinal diseases by regulating intestinal flora dysbiosis, has attracted widespread attention in recent years. Its effect in the treatment of children's neurodevelopmental disorders (NDDs) has gradually been verified, showing great application prospects, which provides new strategies for the treatment of NDDs. This article explores its clinical efficacy, development prospects and some technical limitations that still exist at present by summarizing the relevant animal and clinical studies on FMT treatment for NDDs, aiming to provide relevant references for the subsequent clinical treatment of NDDs. Related Articles | Metrics

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Treatment experience of functional dyspepsia in children by the "Spleen regulation and mediation method" of the Huang's Pediatric School in central Guizhou Province PENG Yu, WU Min, LIU Qiyan, CHEN Zhu, SUN Haipeng, YANG Jianhui, LENG Li, PANG Ping, YE Qian Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 468-472.   DOI: 10.3969/j.issn.1674-3865.2024.06.002 Abstract （293）      PDF（pc） （996KB）（474）       Knowledge map    Save Functional dyspepsia (FD) is a common digestive disorder among children. Clinically, it is primarily characterized by postprandial fullness, early satiety, upper abdominal pain, or a burning sensation in the upper abdomen. It may also be accompanied by symptoms such as belching, acid regurgitation, nausea, vomiting, poor appetite, and abdominal distension, presenting a wide range of manifestations. FD is prone to recurrence and has a relatively prolonged course. According to its main symptoms, it is categorized into conditions such as "abdominal pain," "abdominal distension," "epigastric fullness," and "vomiting" for syndrome differentiation and treatment in traditional Chinese medicine (TCM). The etiology of FD is often attributed to improper diet or post-illness disorders, with the pathogenesis being dysfunction in the ascending and descending mechanisms of the spleen and stomach qi. In Huang's Pediatric School of central Guizhou Province, it is believed that whether it is deficiency or excess, "the failure of the spleen to transport and regulate" is the key to the pathogenesis of pediatric FD, and it is also the core pathogenesis of the symptoms such as "epigastric fullness, distension, and pain." In clinical practice, the severity of symptoms, duration of the disease, and characteristics of the nasal root and eyelids are assessed to determine the nature of the syndrome, including cold, heat, deficiency, and excess. Thus, the "Spleen regulation and mediation method" is established, and the "Spleen-regulating and Fullness-relieving powder" is used for syndrome-differentiated treatment, aiming to rapidly restore the "spleen-transporting" function in children with FD and achieve the state of the spleen "regulating the qi of the four viscera," which provides a clinical reference for TCM treatment of pediatric FD. Related Articles | Metrics

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Research progress in the external treatment of Bi Qiu (allergic rhinitis) deficiency in children from lung and spleen ZHANG Wenwen, XU Yuan, MA Yueyu, LIU Weiwei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 482-485.   DOI: 10.3969/j.issn.1674-3865.2024.06.005 Abstract （278）      PDF（pc） （971KB）（425）       Knowledge map    Save Allergic rhinitis in children falls under the category of "Bi Qiu" in traditional Chinese medicine, which is a disease with a relatively high incidence among school-age children, and  its incidence rate in Chinese children has been increasing year by year.In traditional Chinese medicine it is believed that the incidence of Bi Qiu in children is mainly related to the deficiency of lung, spleen and kidney, and external treatment methods of traditional Chinese medicine such as massage, acupuncture, acupoint patching, Chinese medicine fumigation, and nasal drops can effectively relieve the clinical symptoms and reduce the recurrence rate in the children.This paper summarizes the external treatment methods of traditional Chinese medicine for Bi Qiu deficiency in children from lung and spleen in the recent five years, which can be used as clinical reference. Related Articles | Metrics

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Research progress in the treatment of pediatric diseases with Traditional Chinese Medicine Hot Ironing CHEN Kezhu, ZHANG Wei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 485-488.   DOI: 10.3969/j.issn.1674-3865.2024.06.006 Abstract （276）      PDF（pc） （979KB）（408）       Knowledge map    Save With the development of traditional Chinese medicine(TCM) in the field of pediatrics，the TCM external treatment methods have become more and more important in the treatment of pediatric diseases. TCM Hot Ironing, as one of them, through the inheritance and development of doctors of various generations as well as the combination with modern medicine and innovation, has been gradually progressing from daily health care to clinical treatment. Through the discussion of its historic evolution, mechanism of action and clinical application, this article explores the feasibility and rationality of TCM Hot Ironing in pediatric field. and sorts out the relevant literature on its actual clinical application, so as to provide theoretical support and clinical application reference for its further development in the field of pediatrics. Related Articles | Metrics

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Observation on the clinical efficacy of Xiaoer Dingchuan granule in the intervention of respiratory syncytial virus pneumonia(syndrome of phlegm-heat blocking the lung) LI Ruixue, WANG Xuefeng, TAN Chunying, MENG Bin, ZHANG Xiuying, WANG Hui, LI Zhaoyang Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 87-91.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.019 Abstract （264）      PDF（pc） （1122KB）（376）       Knowledge map    Save Objective To evaluate the clinical efficacy of Xiaoer Dingchuan granule in the intervention of respiratory syncytial virus pneumonia (syndrome of phlegm-heat blocking the lung) in children.Methods A total of 72 children with respiratory syncytial virus pneumonia (syndrome of phlegm-heat blocking the lung) admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Maternal and Child Health Hospital and Benxi Manzu Autonomous County Hospital of Traditional Chinese Medicine from June 2023 to June 2024 were selected as the study subjects,who were randomly divided into control group and observation group with 36 cases in each group.The control group received basic treatment,and the observation group received Xiaoer Dingchuan granule in addition to the treatment for the control group.After 7 days of treatment,the clinical efficacy,TCM syndrome efficacy,single symptom remission time,disappearance time and adverse reactions were compared between the two groups.Results After treatment,the clinical effect and TCM syndrome effect of the observation group were better than those of the control group.The remission time of wheezing,cough,gurgling with sputum and fever in the observation group was shorter than that in the control group,and the differences were statistically significant(P<0.05).No adverse events occurred in the observation group.One case in the control group had nausea and vomiting,which disappeared after treatment.Conclusion Xiaoer Dingchuan granule has a positive therapeutic effect in the treatment of respiratory syncytial virus pneumonia (syndrome of phlegm-heat blocking the lung);the clinical effect is good,accelerating the disappearance of symptoms,and clinical application safety is high,which is worthy of clinical promotion. Related Articles | Metrics

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Analysis of the experience of the Diannan School of Pediatrics in differentiation and treatment of pediatric functional dyspepsia based on the theory of "yang is exposed to wind and yin is exposed to dampness" HE Xiying, XIONG Lei, CAO Ting Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 473-476.   DOI: 10.3969/j.issn.1674-3865.2024.06.003 Abstract （258）      PDF（pc） （982KB）（495）       Knowledge map    Save Functional dyspepsia (FD) is a common gastrointestinal disorder in pediatrics,closely associated with poor diet and lifestyle habits.The main clinical manifestations include upper abdominal fullness,pain,anorexia,belching,nausea,vomiting,and acid regurgitation.If not intervened in time,this disease may lead to growth retardation and malnutrition.In western medicine, this disease is often managed by symptomatic therapy,such as using prokinetic and antisecretory drugs to improve children's appetite and relieve abdominal distension and abdominal pain,but it is easy to recur.Numerous studies have proved that traditional Chinese medicine (TCM) is safe and effective in improving anorexia,belching,abdominal distension,abdominal pain,vomiting,etc.,and can be used alone to treat children with FD.Prof.Xiong Lei,a representative figure of the Diannan School of Pediatrics,believes that the origin of this disease is always in the spleen and stomach:it may be because "yang is exposed to wind" and the pathogenic qi invades the stomach,blocking the flow of qi in the middle jiao,or it may be because "yin is exposed to dampness" and the dampness is trapped in the spleen,resulting in the dysfunction of spleen,which leads to FD.Based on the theory of "yang is exposed to wind and yin is exposed to dampness",prof.Xiong believes that when the spleen and stomach are trapped,non-aromatic TCM cannot activate them.In clinical practice,the use of TCM formulas with aromatic characteristics can activate the spleen and eliminate dampness,regulate qi of the middle jiao,and restore the function of the spleen and stomach,thereby having significant therapeutic effects in the treatment of FD. Related Articles | Metrics

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Investigation in abnormal changes of T wave in electrocardiogram of children and the influencing factors HE Tao, YAO Zhao, ZHU Tongqiu Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 513-517.   DOI: 10.3969/j.issn.1674-3865.2024.06.011 Abstract （254）      PDF（pc） （1001KB）（197）       Knowledge map    Save Objective：To investigate the status quo and influencing factors of abnormal changes of T-wave in electrocardiogram of children in the department of cardiology.Methods：A retrospective study was used.A total of 3 571 children were chosen as the study subjects,who were admitted to the Department of Cardiology of Hunan Children′s Hospital from January 2019 to December 2023,and they were divided into abnormal T-wave group (n=749) and control group (n=2 822) according to whether they had abnormal T-wave or not.The types of T wave abnormalities,age distribution,gender ratio and some other indicators were analyzed,and correlation analysis was carried out by statistical methods to explore the possible influencing factors.Results：A total of 3 571 children in the Department of Cardiology were included,including 749 (20.97%) with abnormal T-wave.T-wave abnormalities occurred mainly in 350 cases of pericarditis (46.73%),followed by 157 cases of myocarditis/cardiomyopathy (20.96%).There was no statistically significant difference in gender or age between the two groups(P>0.05).The proportion of overweight in the abnormal T-wave group was higher,and there was statistically significant difference (P<0.05).The proportion of respiratory system diseases,digestive system diseases,neurological diseases and infectious diseases in abnormal T-wave group was higher,the difference being statistically significant (P<0.05).Logistic regression analysis showed that body mass (overweight),combination with respiratory diseases/digestive diseases/neurological diseases,pericarditis,and myocarditis/cardiomyopathy were independent risk factors for abnormal changes of T-wave in electrocardiogram of children in the Department of Cardiology (P<0.05).Conclusion：Abnormal changes of T wave in electrocardiogram are more common in children in the cardiology department,and the children with pericarditis and myocarditis/cardiomyopathy are more prone to such abnormalities.Meanwhile,attention should also be paid to the children with respiratory diseases,digestive diseases,and neurological diseases,for the risk of abnormal changes of T-wave in their electrocardiograms is also higher. Related Articles | Metrics

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Clinical characteristics of childhood nocturnal enuresis with different severity LI Jie, XU Yuanyuan, GAO Jie, RONG Liping, JIANG Xiaoyun, CHEN Lizhi Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 508-512.   DOI: 10.3969/j.issn.1674-3865.2024.06.010 Abstract （250）      PDF（pc） （1022KB）（403）       Knowledge map    Save Objective：To explore the differences in clinical characteristics between children with severe nocturnal enuresis(NE) and those with non-severe NE.Methods：The clinical data of children with NE who were admitted to Department of Pediatric Nephrology and Rheumatology,The First Affiliated Hospital,Sun Yat-sen University from July 2014 to August 2023 were retrospectively analyzed.The patients included in the study were divided into severe NE group (n=256) and non-severe NE group (n=62) according to the number of wet nights per week.The clinical characteristics of the two groups were compared.Results：Among the 318 NE children with a median age of 8.0(6.3,10.6) years at visiting the hospital,there were 197 boys.The proportion of the children in severe NE group was higher,who had NE in the first half of the night,large amount of enuresis（P<0.05），difficulty in awakening after bedwetting(P<0.001) and wearing diapers during sleep (P<0.01).Conclusion：Difficulty in awakening is the most common clinical manifestation in children with severe NE.Sleeping state and bladder function should be paid attention to in the children with severe NE in order to take individualized diagnosis and treatment measures. Related Articles | Metrics

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Analysis of the association between risk factors and TCM constitution in children with recurrent respiratory tract infections WANG Yulin, WANG Xuefeng, ZHNAG Xiuying, ZHAO Xue, KONG Xinyue Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 489-494.   DOI: 10.3969/j.issn.1674-3865.2024.06.007 Abstract （247）      PDF（pc） （1004KB）（187）       Knowledge map    Save Objective：To explore the risk factors of recurrent respiratory tract infections(RRTI) and the distribution of TCM constitution in children with RRTI and their prone types.Methods：A total of 193 children with RRTI were selected as observation group,who were admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from June 2023 to March 2024，and 212 healthy children were selected as control group during the same period.Based on the TCM constitution theory founded by Academician Wang Qi,the TCM constitution of these children was divided into nine types，and the risk factors and TCM constitution types were investigated in the two groups.Results：Biased TCM constitution,poor appetite or anorexia,poor sleep quality,antibiotic use more than 3 times per year,history of allergic diseases and history of neonatal pneumonia were the risk factors for RRTI.Among the biased TCM constitution types,qi-deficiency constitution,yin-deficiency constitution and inherited special constitution were the prone types of the disease,while the balanced constitution was the protective type of the disease.Conclusion：In terms of risk factors,the children with biased TCM constitution,poor appetite or anorexia,poor sleep quality,antibiotic use more than 3 times per year,history of allergic diseases,and history of neonatal pneumonia are more likely to develop RRTI.Among the biased TCM constitution types,qi-deficiency constitution,yin-deficiency constitution and inherited special constitution are the types of TCM constitution prone to RRTI. Related Articles | Metrics

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Screening for malnutrition risks and analysis of influencing factors in children with pertussis YAN Xili, LIU Jing, HU Qiaomei, TAO Yuqiong Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 50-54.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.010 Abstract （243）      PDF（pc） （1077KB）（134）       Knowledge map    Save Objective To analyze the risk factors for malnutrition in children with pertussis.Methods Totally 124 children with pertussis hospitalized for treatment in Hunan Children′s Hospital from March 2023 to March 2024 were selected as the research subjects.The children were grouped according to whether they had malnutrition,and the indicators with statistical significance in the single factor were included in Logistic regression analysis.Results The malnutrition assessment score for 124 children with pertussis was (3.59±1.74),including 38 cases (30.65%) with malnutrition and 86 cases (69.35%) with normal nutrition.The results of Logistic regression analysis showed that age,severity of disease,presence of other diseases,uncertainty about disease,and sleep status were risk factors for malnutrition in the children (P<0.05).Conclusion Severe malnutrition exists in hospitalized children with pertussis,and low age,severe illness,comorbidities,high levels of uncertainty about disease in family members and poor sleep conditions are all independent risk factors for malnutrition in children.Scientific and reasonable feeding should be carried out to reduce the incidence of malnutrition in children. Related Articles | Metrics