Top Read Articles

Published in last 1 year |

In last 2 years |

In last 3 years |

All

Please wait a minute...


For Selected: Download Citations EndNote Reference Manager ProCite BibTeX RefWorks Toggle Thumbnails

Select

Advances in diagnosis and treatment of pediatric mesenteric lymphadenitis based on integrated traditional Chinese and western medicine Minli GUAN, Xiaolin GAO Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 128-132.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.007 Abstract （2129）   HTML （8）    PDF（pc） （595KB）（133）       Knowledge map    Save Mesenteric lymphadenitis in children is a common pediatric abdominal pain disorder, which has the characteristics of repeated attacks and prolonged course of disease, seriously affecting the physical and mental health and quality of life of children. At present, there is no unified consensus on the diagnostic criteria and treatment of the disease. Anti-infection and symptomatic treatment are still the main clinical treatments, but long-term use of antibiotics can easily cause intestinal flora imbalance and drug resistance. In recent years, the role of probiotics in regulating intestinal microecology, reducing inflammation, shrinking lymph nodes, and assisting the treatment of children with mesenteric lymphadenitis has received increasing attention. The core treatment in traditional Chinese medicine (TCM) is regulating qi and relieving pain, reducing swelling and resolving nodules, and invigorating spleen and stomach, and various interventions are performed, such as oral administration of Chinese medicines, acupoint application, moxibustion and massage, which has achieved great effect. Integrated traditional Chinese and western medicine can synergistically enhance the effect, reduce the recurrence rate and improve the compliance, showing a good application prospect. This article systematically reviews the research progress in etiology, pathogenesis, key diagnostic points, western medicine treatment, traditional Chinese medicine treatment, integrated traditional Chinese and western medicine and probiotics application in children with mesenteric lymphadenitis, and sorts the limitations and controversies of current diagnosis and treatment, so as to provide references for standardized clinical diagnosis and treatment and subsequent researches. Reference | Related Articles | Metrics

Select

Application of the "aromatic orifice-opening" method in pediatric pulmonary and nasal diseases Hang YANG, Mingzhang LI, Xi LI, Xinchen WU, Xiangjuan SUN Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 147-151.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.011 Abstract （2010）   HTML （1）    PDF（pc） （580KB）（155）       Knowledge map    Save "Aromatic orifice-opening" method has a long history and is widely used. Based on children's physiopathological characteristics and the theoretical basis of "the lung opens the orifices in the nose", the "aromatic orifices-opening" method is applied to children's pulmonary and nasal diseases, such as upper airway cough syndrome, allergic rhinitis, sinusitis, adenoid hypertrophy, etc. The causes and mechanisms of the diseases are explored in depth. Due to the nature of dispelling wind of aromatic products, such as Angelica dahurica, Atractylodes lancea, Agastache rugosa, etc., they are used to facilitate the opening of the nosal orifices, in order to promote the lung qi, relieve dampness and invigorate the spleen. The methods of warming yang and consolidating surface, activating blood circulation and removing blood stasis are also used. which result in good effects. A typical medical case is presented here for verification. Reference | Related Articles | Metrics

Select

Traditional Chinese medicine theory of tic disorders comorbid with attention deficit hyperactivity disorder and the application Deqing NI, Jichao SUN Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 512-516.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.009 Abstract （1988）   HTML （6）    PDF（pc） （555KB）（80）       Knowledge map    Save Tic disorders comorbid with attention deficit hyperactivity disorder (ADHD) is a common comorbidity of neurodevelopmental disorders in children. The core symptoms are motor/vocal tics, attention deficit and hyperactive impulsivity, which seriously affect the psychological and social functions of children. Atomoxetine and clonidine are the main drugs in western medicine treatment, but their clinical use is limited due to gastrointestinal and cardiovascular adverse reactions. Traditional Chinese medicines have the advantages of fewer adverse reactions and stable curative effect, which are easily accepted by the parents of children. For this disease, traditional Chinese medicine believes that its etiology is closely related to insufficient endowment, improper diet, emotional disorder, and invasion of external pathogens. The basic pathogenesis lies in the dysfunction of viscera and the imbalance of Yin and Yang, especially the "liver hyperactivity generating wind", which is the key. As a direct factor leading to tic symptoms, wind pathogen is often combined with sputum and fire and other pathological factors, forming a complex pathogenesis such as wind-sputum disturbance and wind-fire stimulation, which leads to the co-occurrence of tic symptoms with attention deficit and hyperactive impulse symptoms. Clinically, based on the pathogenesis, it can be divided into five main syndrome types: syndrome of liver wind carrying phlegm, syndrome of kidney deficiency and liver hyperactivity, syndrome of external wind causing activity, syndrome of latent fire in spleen and stomach and syndrome of heart and liver fire hyperactivity. The ultimate purpose of treatment is to harmonize Yin and Yang of viscera, and the core treatment principle of calming the liver and stopping wind is established. The pathological factors such as wind, phlegm and fire are concurrently managed according to the principle of "simultaneous application of principal and subordinate treatments". Based on different syndrome types, appropriate treatment principles and methods and prescriptions are selected for treatment. Reference | Related Articles | Metrics

Select

Observation on the curative effect of Jianpi Yiqi ointment in treating anorexia(spleen and stomach qi-deficiency syndrome) in children Qimin TANG, Yishi TU Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 472-476.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.003 Abstract （1965）   HTML （6）    PDF（pc） （595KB）（77）       Knowledge map    Save Objective To explore the clinical effects of Jianpi Yiqi (tonifying spleen and benefiting qi) ointment in the treatment of pediatric anorexia (spleen stomach qi-deficiency syndrome). Method One hundred children with anorexia(spleen and stomach qi-deficiency syndrome) admitted to the Pediatric Department of Jingzhou Hospital of Traditional Chinese Medicine from January 2023 to February 2024 were selected as the research subjects, and they were randomly divided into a control group and an observation group, each consisting of 50 cases. The control group was treated with oral administration of Xingpi Yanger granules, while the observation group was treated with oral administration of Jianpi Yiqi ointment. The total effective rate of treatment, the excretion rate of urinary D-xylose, the ratio of salivary amylase activity, the levels of gastrin, motilin and neuropeptide Y, the improvement in symptom scores, and the body weight and height before and after treatment were observed and compared between the two groups. Results The total effective rate of treatment for children with anorexia(spleen and stomach qi-deficiency syndrome) in the observation group was 98.0%(49/50), significantly higher than that in the control group (84.0%, 42/50), with a statistically significant difference(P<0.05). After treatment, the urine D-xylose excretion rate, salivary amylase activity ratio, gastrin level, motilin level, and neuropeptide Y level in the observation group were higher than those in the control group, with statistically significant differences(P<0.05). After treatment, the symptom scores(food intake, appetite, and eating time) in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in body weight or height between the two groups before and after treatment(P>0.05). Conclusion Jianpi Yiqi ointment in the treatment of children with anorexia(spleen and stomach qi-deficiency syndrome) can significantly improve the therapeutic effect on the children, significantly improve a series of clinical indicators in them, and promote the relief of the clinical symptoms. Table and Figures | Reference | Related Articles | Metrics

Select

Experience of Professor Jia Liujin in treating pediatric pneumonia with dyspnea and cough Qing YANG, Jingnan XUE, Liujin JIA Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 111-115.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.004 Abstract （1941）   HTML （4）    PDF（pc） （577KB）（609）       Knowledge map    Save Professor Jia Liujin believes that lung qi depression and closure is the core mechanism of pediatric pneumonia with dyspnea and cough, and that relieving depression and opening up closure is the main method of treatment for this disease, so he proposes a sequential therapy that focuses on dispersing lung qi in the early stage, clearing in the middle stage, and tonifying in the late stage. The article also summarizes Professor Jia's experience in the diagnosis and treatment of pediatric pneumonia with dyspnea and cough, pointing out that it is important to focus on the identification of early pneumonia in the clinical diagnosis and treatment process, and summarizes the experience of using single and pair of medicines, which provides a reference for the clinical diagnosis and treatment of pediatric pneumonia with dyspnea and cough. Reference | Related Articles | Metrics

Select

Study on the assessment of "the TCM Constitution Scale for Children Aged 1+ to 7 Years" Xuefeng WANG, Qi WANG, Minghua BAI, Ji WANG, Hua XU, Lining WANG, Baoqing ZHANG, Zhenze CUI, Zhenqi WU, Xue ZHAO, Xiuying ZHANG, Xinyue KONG, Hao HE, Xinwei LIU Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 477-487.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.004 Abstract （1938）   HTML （9）    PDF（pc） （578KB）（80）       Knowledge map    Save Objective To test the reliability and validity of "the TCM Constitution Scale for Children Aged 1+ to 7 Years", and to optimize it. Methods Healthy children from 5 hospitals were selected for on-site inclusion. The reliability and validity of the scale were analyzed by means of decision value-critical ratio, item-total correlation method, Cronbach's α coefficient, split half reliability, retest reliability, and factor analysis,etc.,and the items with problems were summarized. Results Independent sample t-test was performed for the high and low subscales of 9 subscales, and the items of each subscale had t>3.000, P<0.05, without modification or deletion. Pearson correlation coefficient test was performed on 9 subscales, and the correlation coefficients of items Qi deficiency 9 and blood stasis 40 with the total score were all < 0.4, so it was considered to change or delete them. The Cronbach's α coefficient of the total scale and each subscale was >0.6, and the internal consistency was acceptable. After deleting items 5, 9, 13, 23, 29, 36, 40, 52, 58, 59, and 62, Cronbach's α coefficient increased, and it was considered to delete or change them. Principal component analysis was used to extract common factors based on eigenvalue greater than 1, and a total of 15 common factors were extracted, with a cumulative contribution rate of 62.226%. In order to further fit nine TCM constitution theories, the number of extraction factors was set at 9, and the cumulative contribution rate was shown to be 50.342%.In the structural validity analysis of each subscale, the one with 1 component had the dampness-heat quality and the peace quality; the one with 2 components had the Qi-deficiency quality, Yang-deficiency quality, phlegm-dampness quality, blood-stasis quality, Qi-stagnation quality and special quality subscale; the one with 3 components had the Yin-deficiency quality subscale. The factor loading for all subscale items was >0.4. Conclusion The reliability and validity of the "the TCM Constitution Scale for Children Aged 1+ to 7 Years" for the assessment of children's physical constitution are acceptable, but it still needs to be adjusted to improve its reliability and validity. Later, a discussion with relevant experts will be conducted, and the items with problems will be deleted or modified to form the second version of test of the "the TCM Constitution Scale for Children Aged 1+ to 7 Years", in order to make this scale more suitable for clinical identification of children's physical constitution. Table and Figures | Reference | Related Articles | Metrics

Select

Research progress on influencing factors for childhood asthma control Lizheng JIN, Jiapei LIN, Hanyu SUN, Guangju HUANG Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 104-110.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.003 Abstract （1930）   HTML （3）    PDF（pc） （676KB）（212）       Knowledge map    Save Asthma is the most common chronic airway inflammatory disease in children, and its control status is closely related to the disease burden and prognosis. Despite the continuous advancement in diagnosis and treatment technologies, the control rate of childhood asthma globally and in China remains unsatisfactory. This article systematically elaborates on the factors affecting childhood asthma control from three aspects: first, discuss how the individual characteristics such as gender, obesity, comorbidities, etc. affect the asthma control physiologically; secondly, analyze how the environmental factors such as outdoor air pollution, indoor allergen exposure, tobacco exposure, and respiratory virus infections aggravate asthma symptoms; finally, the discussion focuses on management behaviors, especially the effect of treatment compliance and inhaler use techniques on asthma control. The aim is to provide a reference for accurately identifying high-risk factors and formulating individualized intervention strategies in clinical practice. Reference | Related Articles | Metrics

Select

Observation on the efficacy of pelvic floor magnetic stimulation combined with bladder function training in children with neurogenic bladder after spinal cord injury Yingying WU, Jinming LI, Caixiao SHI, Qing SHANG, Xiangli WANG, Liang HAN Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 174-179.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.015 Abstract （1924）   HTML （1）    PDF（pc） （591KB）（73）       Knowledge map    Save Objective To explore the effects of pelvic floor magnetic stimulation combined with bladder function training on children with neurogenic bladder after spinal cord injury. Methods Sixty children with neurogenic bladder after spinal cord injury who were treated at Zhengzhou University Affiliated Children's Hospital from January 2023 to October 2025 were selected as the research subjects. According to the order of admission, 30 cases admitted from January 2023 to May 2024 were assigned to the control group, and 30 cases admitted from June 2024 to October 2025 were assigned to the observation group. The control group received conventional rehabilitation treatment, nursing measures, and bladder function training, while the observation group received pelvic floor magnetic stimulation in addition to the treatment for control group. The scores of voiding symptoms [core lower urinary tract symptom score (CLSS), urinary symptom distress scale (USDS)], neurogenic bladder symptom score (NBSS), and urodynamic indicator scores were compared between the two groups before and after the intervention. Results After the intervention, the CLSS, USDS, and NBSS of both groups were lower than those before the intervention, and the observation group was lower than the control group, with statistically significant differences(P<0.05). Concerning the urodynamic indicators, after the intervention, the maximum bladder capacity and internal bladder pressure of both groups were higher than those before the intervention, and the observation group was higher than the control group, with statistically significant differences(P<0.05); after the intervention, the residual urine volume of both groups was lower than that before the intervention, and the observation group was lower than the control group, with statistically significant differences(P<0.05). Conclusion Pelvic floor magnetic stimulation combined with bladder function training can improve the voiding symptoms of children with neurogenic bladder after spinal cord injury, relieve neurogenic bladder symptoms, and promote the recovery of urodynamic indicators, which has significant clinical effects and application value. Table and Figures | Reference | Related Articles | Metrics

Select

Clinical efficacy analysis of foot bath with Jiebiao Toure decoction combined with meridian scraping in the treatment of exogenous fever (wind-heat type) in children Xuejiao WANG, Chen SHEN, Miao YU, Yiwen GAO, Heng LI Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 168-173.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.014 Abstract （1911）   HTML （2）    PDF（pc） （638KB）（529）       Knowledge map    Save Objective To explore the intervention effect of foot bath with Jiebiao Toure decoction (decoction for resolving symptoms and clearing heat) combined with meridian scraping on children with wind-heat-type exogenous fever. Method A total of 100 children with exogenous fever (wind-heat type) admitted to Pediatric Department of Affiliated Hospital of Changchun University of Chinese Medicine from April 2024 to October 2024 were selected and randomly divided into a control group and an observation group, each consisting of 50 cases. The control group received conventional treatment with western medicines, while the observation group received the treatment of foot bath with Jiebiao Toure decoction combined with meridian scraping in addition to the conventional western treatment. The total clinical effective rate after 3 days of treatment, changes in TCM symptom scores (red throat, nasal congestion, runny nose and cough), body temperature at each time point, time of complete defervescence, onset time of defervescence, frequency of antipyretic drug use, and average length of hospital stay were observed in both groups. Result There were 4 cases of loss of follow-up in the control group and 3 cases of dropping out in the observation group, and finally 93 patients completed the whole course of observation (46 in the control group and 47 in the observation group). The total effective rate was 89.4% (42/47) in the observation group, higher than the control group (71.7%, 33/46), and the difference was statistically significant(P<0.05). The symptom scores of red throat, runny nose and nasal congestion significantly decreased after treatment compared to before treatment, and the observation group was lower than the control group, with statistically significant difference(P<0.05). There was no statistically significant difference in symptom score of cough(P>0.05).The measurements at 1.5 h, 48 h and 72 h after treatment showed that the body temperature of the observation group was significantly lower than that of the control group, and all the differences were statistically significant(P<0.05). The time of complete defervescence, the onset time of defervescence and the average length of hospital stay were shorter in the observation group than in the control group, and the differences were statistically significant(P<0.01). There was no statistically significant difference in the frequency of antipyretic drug use between the two groups(P>0.05). Conclusion The combination of Chinese herbal medicine foot bath with meridian scraping can reduce the body temperature of children and improve clinical symptoms, has a significant antipyretic effect, and effectively shortens the treatment cycle. Table and Figures | Reference | Related Articles | Metrics

Select

Analyzing the experience in the treatment of children's tic disorders from the perspective of "liver collaterals" Yanqiu ZHOU, Aidong LIU, Xiaochun FENG, Xu YAN Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 521-526.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.011 Abstract （1911）   HTML （7）    PDF（pc） （676KB）（71）       Knowledge map    Save In recent years, the incidence of tic disorders in pediatric clinical practice has been steadily increasing, emerging as a significant issue affecting the physical and mental development of affected children. This condition not only manifests as involuntary muscle tics or abnormal vocalizations but may also be accompanied by emotional and behavioral problems, directly impacting children's academic performance, daily life, and peer interactions. It urgently calls for collaborative attention from families, schools, and the healthcare institutions. Western medicine treatments may cause side effects such as sedation or drowsiness, and parents often worry about these adverse reactions and thus refuse to allow their children to take such medications. Traditional Chinese medicine (TCM) takes a different approach, proposing the concept of collaterals—organic pathways connecting internal organs and external limbs, and communicating between upper and lower parts of the body, which provides a unique perspective for TCM treatment. Based on the profound theoretical foundation of traditional Chinese medicine and rich clinical practice, the supervisor, Professor Feng Xiaochun, puts forward the academic idea of "differentiated treatment for children's diseases based on collaterals", and creatively believes that the core pathogenesis of the disease lies mainly in the "liver collateral imbalance", so the principle of its clinical treatment is to calm the liver and stop the wind and relax the tendons and promote the circulation. This is achieved by selecting herbal formulas with the effects of calming the liver, stopping wind, relieving spasms, and promoting circulation, while skillfully combining the external treatment of massage and herbal plaster application (Pingdong ointment), thus forming an integrated treatment system of "internal medication and external regulation" for childhood tic disorders. This approach has achieved significant therapeutic effects and advanced the prevention and treatment of childhood diseases from experience-based inheritance to precise intervention, bringing new insights to the prevention and treatment of childhood diseases. Reference | Related Articles | Metrics

Select

Clinical observation of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia(spleen dysfunction syndrome) Ruiqi CAI, Oumei HAO, Xuefeng WANG, Kexin ZHANG Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 461-465.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.001 Abstract （1900）   HTML （15）    PDF（pc） （567KB）（129）       Knowledge map    Save Objective To observe the efficacy of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia of spleen dysfunction syndrome, as well as its effects on TCM syndrome scores, trace elements and hemoglobin in children. Methods A total of 86 children with anorexia who visited the Pediatric Outpatient Department of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from October 2023 to December 2024 were selected as research subjects. They were randomly divided into a control group and an observation group, with 43 cases in each group. Both groups were treated with oral lysine inositol vitamin B12 oral liquid, while the observation group was additionally given Xiaoji Lipi powder and anorexia plaster. Both groups received a 4-week course of treatment. TCM syndrome scores, efficacy, trace elements(Zn, Fe, Ca), hemoglobin and adverse reactions were compared between the two groups. Results The effective rate of the observation group was 95.35%(41/43), which was higher than 81.40%(35/43) of the control group, and there was a statistically significant difference(P<0.05). After treatment, the scores of symptoms, such as poor appetite, reduced food intake, hiccups and belching, abdominal distension, sallow complexion and irregular defecation, as well as the total scores in both groups were significantly lower than those before treatment；moreover, the improvement of each symptom score and total score in the observation group was significantly better than that in the control group, there were statistically significant differences(P<0.05). After treatment, the levels of trace elements(Zn, Fe, Ca) and hemoglobin in both groups were significantly higher than those before treatment, and the improvement of each index in the observation group was significantly superior to that in the control group， there were statistically significant differences(P<0.05). There was no statistically significant difference in adverse reactions between the two groups(P>0.05). Conclusion The application of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia of spleen dysfunction syndrome can significantly improve appetite, increase food intake, and promote the recovery of nutritional status and the absorption of trace elements. It is significantly effective, safe and reliable, and is worthy of promotion. Table and Figures | Reference | Related Articles | Metrics

Select

Exploring Professor Xu Hua's experience in treating pediatric patients post-hematopoietic stem cell trans⁃plantation based on data mining Baoyi HUANG, Lichen YI, Yabin CHEN, Hua XU Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 157-167.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.013 Abstract （1883）   HTML （1）    PDF（pc） （1553KB）（57）       Knowledge map    Save Objective To explore the patterns of traditional Chinese medicine (TCM) usage in Professor Xu Hua's interventions for pediatric patients post-hematopoietic stem cell transplantation (HSCT) through data mining techniques， summarize her clinical experience， and provide references for promoting the clinical application of TCM in the field of pediatric HSCT. Methods Prescriptions from pediatric patients treated by Professor Xu Hua at the First Affiliated Hospital of Guangzhou University of Chinese Medicine (outpatient or inpatient) between January 1， 2021， and December 12， 2024， were collected. Various data mining techniques， including frequency， dosage， and property analysis of TCM， association rule analysis， complex network construction， core TCM clustering analysis， and community analysis of compatible TCM， were employed to objectively present Professor Xu Hua's medication patterns. Results A total of 230 prescriptions involving 177 TCM herbs were included. The four natures of the herbs were predominantly warm， neutral， and slightly warm， while the five flavors were mainly sweet， pungent， and bitter. The meridians most frequently targeted were the spleen， lung， and stomach. The top five herb pairs with the highest co-occurrence frequency were Pinellia ternata(Fabanxia)-Poria(Fuling)， stir-fried Atractylodes macrocephala(Fuchaobaizhu)-Poria(Fuling)， stir-fried Atractylodes macrocephala(Fuchaobaizhu)-Pinellia ternata(Fabanxia)， tangerine peel(Chenpi)-stir-fried Atractylodes macrocephala(Fuchaobaizhu)， and tangerine peel(Chenpi)-Poria(Fuling). Herb pairs with 100% confidence included honey-fried Ephedra(Mimahuang)-bitter apricot kernel(Kuxingren)， Peucedanum praeruptorum(Qianhu)-bitter apricot kernel(Kuxingren)， dragon bone(Longgu)-oyster shell(Muli)， Ilex pubescens(Maudongqing)-honey-fried Ephedra(Mimahuang)， Ilex pubescens(Maudongqing)-bitter apricot kernel(Kuxingren)， and clam shell(Haqiao)-Pinellia ternata(Fabanxia). Six categories of core TCM prescriptions were identified， with Category 1(comprising Pseudostellaria heterophylla(Taizishen)， Poria(Fuling)， stir-fried Atractylodes macrocephala(Fuchaobaizhu)， Aucklandia lappa(Muxiang)， Pueraria lobata(Gegen)， Pogostemon cablin(Guanghuoxiang)， Pinellia ternata(Fabanxia)， tangerine peel(Chenpi)， charred hawthorn(Jiaoshanzha)， and licorice slice(Gancaopian) containing the most frequently used herbs. Conclusion Professor Xu Hua's interventions for pediatric patients post-HSCT primarily focus on strengthening the spleen's function， complemented by replenishing qi and nourishing yin， regulating the lung and kidney， resolving phlegm， and dispelling stasis. She prefers using herbs that serve both medicinal and dietary purposes， aiding in the generation and circulation of qi， blood， and body fluids in post-HSCT children， thereby improving the dysfunction or deficiency of multiple organs. Table and Figures | Reference | Related Articles | Metrics

Select

Exploration of prescription patterns in Professor Wang Xiaoming's treatment for pediatric food accumulation and stagnation based on data mining Qing WANG, Yaqin CHEN, Danfei YIN, Suli WANG, Xiaoming WANG Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 466-471.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.002 Abstract （1876）   HTML （6）    PDF（pc） （796KB）（70）       Knowledge map    Save Objective To collate and analyze Professor Wang Xiaoming's traditional Chinese Medicine(TCM) prescriptions for pediatric food accumulation and stagnation, and summarize her clinical experience in medication for pediatric food accumulation and stagnation. Methods Prescription data from the outpatient department of Wang Xiaoming's Distinguished TCM Practitioner Studio in Zhejiang Province from January 1, 2019 to December 31, 2024 were collated and screened. Statistical software was employed to perform frequency analysis, analysis of medicinal properties (nature, flavor, channel tropism), analysis of medicinal efficacy, association rule analysis, and cluster analysis of the constituent herbs. Results A total of 382 prescriptions were screened out, identifying 19 high-frequency herbs. These herbs predominantly targeted the spleen, lung, stomach, and liver channels, with bitter, sweet, and pungent flavors being most common, and cold, warm, and neutral properties prevailing. The most frequently used herbs belonged to the categories of digestion-promoting, deficiency-tonifying and qi-regulating medicinals. The second-order association rule with the highest support was Fuling-Jineijin.The third-order association rule with the highest support was Baizhu-Fuling-Jineijin.Cluster analysis of high-frequency core herbs revealed two combinations. Conclusion Professor Wang's treatment for pediatric food accumulation and stagnation focuses on the core pathogenesis of "food accumulation leading to impaired spleen transportation, and qi stagnation, often accompanied by internal heat or liver qi stagnation." She establishes the core therapeutic principles of "promoting digestion and removing stagnation, strengthening the spleen and boosting qi, and regulating qi and harmonizing the middle Jiao." Innovatively, she emphasizes the simultaneous treatment of the liver and spleen and the clearance of stagnated heat. Table and Figures | Reference | Related Articles | Metrics

Select

Research advances in the treatment of pediatric epilepsy with Pingxian granules Yijue JING, Zhengyu YAO, Lü GAO Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 488-492.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.005 Abstract （1872）   HTML （8）    PDF（pc） （577KB）（82）       Knowledge map    Save Epilepsy, a chronic neurological disorder, has become a significant public health problem impacting children's health and development. Pingxian granules, formulated by Professor Zhang Shiqing, National Renowned TCM Physician, have gradually been proved in the effect on pediatric epilepsy, demonstrating substantial application potential and offering a novel therapeutic strategy in the treatment of pediatric epilepsy. Through sorting out the previous clinical and basic research results in the treatment of pediatric epilepsy by Pingxian granules, this paper discusses the mechanisms of action and development prospects, as well as current technical limitations, aiming to offer ideas for further exploring the therapeutic mechanism of Pingxian granules and provide reference for the prevention and treatment of pediatric epilepsy in traditional Chinese medicine. Reference | Related Articles | Metrics

Select

Professor Wang Xuefeng's exploration in the clinical experience in pediatric pneumonia with dyspnea and cough based on the theory of "What is within manifests without" Shihui TANG, Xuefeng WANG, Kexin ZHANG Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 137-140.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.009 Abstract （1859）   HTML （1）    PDF（pc） （543KB）（50）       Knowledge map    Save "What is within manifests without" is the core concept in traditional Chinese medicine (TCM) for understanding diseases and exploring pathogenesis. Its essence lies in the principle -- "what is inside must manifest itself outside," meaning that the functional activities and pathological changes of the body's internal organs, qi and blood will inevitably manifest themselves through certain external signs. This theory forms the foundation of TCM's diagnostic approach of "judging the external to infer the internal". In pediatrics, children exhibit physiological characteristics of "immature yin and yang" and "frequent lung deficiency", with their pathological states being manifested through multiple external signs such as complexion, tongue coating, and pulse. In terms of pneumonia with dyspnea and cough, the disease progression is characterized by rapid transmission and transformation between cold and heat, deficiency and excess. Professor Wang Xuefeng, based on the theory of "What is within manifests without", investigates the correlation between external manifestations and internal pathogenesis to discern the deficiency or excess of internal organs, the exuberance or decline of pathogenic qi, and the progression or regression of the disease. He systematically explores the application of this theory in the differentiation of pediatric pneumonia with dyspnea and cough, the selection of therapeutic prescriptions, and the assessment of prognosis, providing clearer theoretical references and practical insights for clinical diagnosis and treatment in pediatrics. Reference | Related Articles | Metrics

Select

Research on the clinical experience of Professor Xu Rongqian in treating children with cough variant asthma Zhe ZHOU, Huina LU, Ming ZHANG, Ling DONG Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 116-121.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.005 Abstract （1859）   HTML （7）    PDF（pc） （689KB）（100）       Knowledge map    Save Based on years of clinical experience, Professor Xu Rongqian first proposed the theory of "syndrome differentiation of Shen Hun Yi Po Zhi", concluding that the primary pathological location of pediatric cough variant asthma lies in the lungs. "The lungs store the Po" and are connected to the multiple organs through the "skin meridians", thus being related to the multiple organs. "The liver stores the Hun", so he advocates that treatment should focus on the lungs and liver. The etiology lies in exogenous pathogens and internal damage, and its relationship with "wind"，"phlegm" and "stasis" is the closest. There are many pathogenic mechanisms, which mainly include invasion of wind evil, restlessness of lungs and Po; retention of tenacious phlegm, instability of Shen Hun Yi Po Zhi (five Shen); wind-phlegm blocking lungs, restlessness of Hun and Po; phlegm stasis blocking meridians, inability to communicate of Hun and Po. The basic treatment principles are generally "dispelling wind and activating blood circulation, resolving phlegm and relieving cough, and calming Hun and securing Po. "The article summarizes Professor Xu's clinical experience in treating children with cough variant asthma from five aspects: dispelling wind and resolving phlegm, calming Hun and securing Po; regulating the lungs and liver, eliminating the evil and calming Hun; activating blood circulation and resolving stasis, dredging meridians and securing Po; skillfully applying the principles of ascending, descending, floating, and sinking in medication; protecting vital qi while avoiding excessive medication. A verified case is attached to demonstrate its efficacy. Reference | Related Articles | Metrics

Select

Research status of specific immunotherapy for childhood asthma Xuting WANG, Peng ZHOU Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 122-127.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.006 Abstract （1859）   HTML （1）    PDF（pc） （582KB）（131）       Knowledge map    Save By searching databases such as PubMed and CNKI, the clinical studies, meta-analyses and mechanistic studies on asthma-specific immunotherapy for children in recent years are screened, and the research progress in major interventions such as biologics and allergen-specific immunotherapy (AIT) is summarized and evaluated. Specific immunotherapy has shown some clinical potential in childhood asthma. Biologics can significantly reduce the rate of acute attacks and improve lung function in children with severe asthma; AIT has long-term efficacy in children with allergic asthma, but individual responses vary greatly. Cell therapies, such as regulatory T cell infusions, are in the experimental stage but have significant potential. Bacterial lysates may enhance immunomodulation by modulating the microbiota, but the mechanism needs to be further verified. Specific immunotherapy is still an important means in the treatment of asthma in children, and different strategies have their own advantages; individualized therapy and combined multi-target intervention need to be involved to improve the efficacy in the future. The results of this study provide a theoretical basis for further optimizing immunotherapy strategies for childhood asthma. Reference | Related Articles | Metrics

Select

Professor Zheng Jian's experience in treating refractory nephrotic syndrome in children based on the principle of "phased collaboration and sequential synergy" Meifang CHEN, Jian ZHENG Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 141-146.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.010 Abstract （1836）   HTML （1）    PDF（pc） （579KB）（83）       Knowledge map    Save This paper summarizes Professor Zheng Jian's academic thought and clinical experience in treating refractory nephrotic syndrome (RNS), focusing on his integrated traditional Chinese and western medicine scheme of treating RNS with traditional Chinese medicine and rituximab (RTX). Based on the combination of disease and syndrome and clarification of pathogenesis, a strategy of treatment by stages is established in the scheme, which consolidates the foundation by strengthening the spleen and tonifying the kidney and deals with its symptoms by promoting blood circulation and eliminating dampness, and dynamically adjusts the traditional Chinese medicine prescriptions according to the different stages of the disease and the characteristics of RTX, so as to leverage the synergistic effects of integrated traditional Chinese and western medicine to reduce toxicity and enhance efficacy. Clinical practice has proved that this scheme can significantly enhance the efficacy of RTX, reduce adverse reactions and recurrence rate of RNS, and provide an effective reference for the treatment of RNS with integrated traditional Chinese and western medicine. Table and Figures | Reference | Related Articles | Metrics

Select

Progress in traditional Chinese and western medicine treatments for idiopathic short stature Ruoyun REN, Wenqing YANG Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (6): 498-502.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.06.007 Abstract （1834）   HTML （10）    PDF（pc） （524KB）（78）       Knowledge map    Save Idiopathic short stature is a collective term for a group of highly heterogeneous conditions with unknown causes, primarily responsible for the short stature in children. If not promptly addressed, it can easily lead to psychological disorders and social adaptation difficulties in patients, significantly impacting their lifelong development quality. Currently, in western medicine, the core treatment approach is recombinant human growth hormone replacement therapy, supplemented by drugs that regulate the developmental process, such as gonadotropin-releasing hormone analogs and aromatase inhibitors. In traditional Chinese medicine, a syndrome-differentiated treatment system is employed, and internal administration of herbal medicines combined with external therapies of acupuncture, massage, and topical application of patches is used to promote bone growth, regulate endocrine metabolism, and improve physical condition, which demonstrates unique therapeutic effects and mechanism advantages. Reference | Related Articles | Metrics

Select

Systematic analysis of pediatric Chinese patent medicines and simple preparations included in the 2025 edition of the Chinese Pharmacopoeia Muyuan WAN, Pengfei YI, Qingyi XU, Jinsong YAN, Tian ZHANG, Liqin LIU, Mengqi CHEN, Qingqing LI Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (1): 60-66.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.01.012 Abstract （1775）   HTML （2）    PDF（pc） （762KB）（472）       Knowledge map    Save Objective To investigate and analyze the status of pediatric Chinese patent medicines and simple preparations included in the 2025 edition of Chinese Pharmacopoeia (Volume I), in order to provide reference for the rational use of pediatric Chinese patent medicines and simple preparations in clinical practice. Methods Based on the contents contained in the 2025 edition of Chinese Pharmacopoeia (Volume I), the current status of pediatric Chinese patent medicines and simple preparations was systematically analyzed in terms of varieties, dosage forms, efficacy and indications, usage and dosage, and safety information, and the prescription rules of high-frequency drugs were explored. Results The 2025 edition contains 1 616 kinds of traditional Chinese patent medicines and simple preparations, including 100 kinds of traditional Chinese patent medicines and simple preparations for children whose names include "child" and "pediatric", accounting for 6.19%, while in the 2020 edition, there are 53 kinds of Chinese patent medicines and simple preparations for children, so the 2025 edition contains 47 more than the 2020 edition. There are 642 kinds of traditional Chinese patent medicines and simple preparations that can be used for children, and 61 kinds of traditional Chinese patent medicines and simple preparations that should be used with caution or must be prohibited. The main efficacy of traditional Chinese patent medicines and simple preparations for children is cough-relieving and asthma-relieving (21%), and the main dosage form is granules (24%). A majority of the medicines (65%) has usage based on specific age classification, but not many with adverse reactions clarified, accounting for only 26% of specific drugs for children. SPSS Statistics 21.0 and SPSS Modeler 18.0 software were used to conduct systematic cluster analysis and association rule analysis on high-frequency drugs (frequency>10). Four cluster prescriptions were obtained, C1: malt, Shenqu, hawthorn, betel nut, Poria cocos, tangerine peel, Atractylodes macrocephala, Ophiopogon japonicus; C2: Pueraria lobata, buffalo horn, Forsythia suspensa, Isatis root, honeysuckle, Scutellaria baicalensis, Bupleurum chinense, Rheum palmatum, Gardenia jasminoides; C3: bezoar, borneol, musk, Coptis chinensis, cinnabar, peppermint; C4: bitter almond, gypsum, Platycodon grandiflorum, Scrophularia suspensa, Anemarrhena chinensis, Bulbus fritillaria, licorice. Conclusion The development of traditional Chinese patent medicines and simple preparations for children in China has some problems, such as lack of specific varieties, unclear usage and dosage, and non-standard functions and indications. We should encourage R&D and innovation, improve drug standards, strengthen clinical research, strengthen rational drug use guidance and establish a monitoring system and adopt other measures, which can effectively improve the current situation of the use of traditional Chinese patent medicines and simple preparations for pediatric use, improve its safety and effectiveness, and better safeguard children's health. Table and Figures | Reference | Related Articles | Metrics