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Individualized intervention strategies in the treatment of childhood and adolescent obesity based on precision medicine LI Ping, YANG Fan, LIU Hanmin Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 1-7.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.001 Abstract （1137）      PDF（pc） （1165KB）（1744）       Knowledge map    Save Childhood and adolescent obesity has become a global challenge in public health.Its high weight regain rate and risks of metabolic complications highlight the limitations of traditional intervention strategies.This review systematically explores individualized intervention strategies for obesity in children and adolescents in the context of precision medicine,breaking the traditional "one-size-fits-all" model.It integrates multi-omics technologies with intelligent management methods,proposing a multidimensional framework for precise intervention.First,a precise diagnosis and evaluation system is constructed based on multi-modal data,including genomics,radiomics,and gut microbiomics,to identify genetic susceptibility,metabolic phenotypes and microbiome characteristics,laying the foundation for stratified interventions.Secondly,individualized intervention plans are developed based on genetic risk scores,epigenetic regulatory mechanisms,and gut microbiome-targeted therapies:gene-guided strategies aim to optimize dietary structure through multi-gene risk assessments; epigenetic interventions aim to regulate DNA methylation and histone modification by taking advantage of nutrients (such as methyl donors and short-chain fatty acids),reversing metabolic dysregulation; microbiome remodeling aims to improve energy metabolism balance through probiotics and synbiotics.Furthermore,artificial intelligence and wearable devices are employed for dynamic monitoring in multiple scenarios.By collaborating with multidisciplinary teams in nutrition,sports medicine,and psychology,a smart management model of "hospital-family-community" network is established.While precision medicine offers groundbreaking directions for childhood obesity treatment,challenges such as biomarker validation,data integration,and long-term efficacy evaluation remain to be addressed.This review provides theoretical foundations and practical pathways for the improvement in the effectiveness and sustainability of interventions,emphasizing the need to integrate interdisciplinary innovative technologies in the future in order to promote the transformation of childhood obesity management toward precision and intelligence. Related Articles | Metrics

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Research progress of neurotransmitter imbalance in tic disorders JIANG Ling, ZHANG Di, LlU Ying Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 132-136.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.007 Abstract （476）      PDF（pc） （1040KB）（802）       Knowledge map    Save Tic disorder(TD) is a neuropsychiatric disorder,the exact causes and mechanisms of which are not yet fully understood.In recent years,the prevalence of tic disorder has been on the rise.Patients with TD often present with comorbidities such as attention deficit hyperactivity disorder,obsessive compulsive disorder,learning difficulties,anxiety,and depression.These issues not only negatively impact children's academic performance but may also bring great trouble to their growth,development,and mental health.Researches have indicated that the occurrence of TD is closely related to various factors,including neurotransmitter imbalance,genetic factors,psychosocial factors,and infections or immune factors.Neurotransmitters play a crucial role in maintaining normal function of nervous system,and in TD patients,there may be neurotransmitter imbalance,which affects their behavior and cognitive functions.In depth research in the pathogenesis of TD,especially in neurotransmitter imbalance,helps us better understand its pathological processes and provides new therapeutic approaches and strategies for controlling its symptoms.Through targeted treatment and interventions,symptoms can be effectively alleviated,which helps patients improve their quality of life and reduce the negative impact on society and families.This article mainly reviews the relationship between neurotransmitter imbalance and the development of tic disorder. Related Articles | Metrics

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Research progress in causes of premature puberty in traditional Chinese and western medicine LIU Qiannan, WANG Yanchao, MIAO Yizhuo, LI Lan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 13-16.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.003 Abstract （439）      PDF（pc） （1085KB）（497）       Knowledge map    Save Since the 1970s,it has been believed in traditional Chinese medicine (TCM) that the pathogenesis of precocious puberty is primarily associated with yin-deficiency and fire-excess,and the treatments that nourish yin and purge fire are advocated.Therefore,an integrated treatment strategy combining TCM and western medicine has gradually been formulated.Modern medical research indicates that precocious puberty results from the interplay of genetic and environmental factors,involving heredity,diet,chemical substance interference,and psychological factors.TCM emphasizes the combined influence of internal and external factors,such as dietary irregularities and emotional disturbances,and focuses on therapeutic methods like nourishing yin,purging fire,soothing the liver,and relieving stagnation.The integrated approach of TCM and western medicine offers a more comprehensive treatment plan for precocious puberty.The TCM theory of "preventive treatment of disease" underscores the importance of prevention,reducing risk factors and performing proactive treatment to avoid long-term complications. Related Articles | Metrics

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Effect of Jingling oral liquid on memory function in rats of ADHD animal model LIU Liwei, CHENG Shen, YANG Yufang, CHEN Jian, CHEN Yuyan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 27-32.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.006 Abstract （434）      PDF（pc） （1379KB）（245）       Knowledge map    Save Objective To explore the effect of Jingling oral liquid on improving memory function and promoting myelination in young spontaneously hypertensive rats (SHR) of ADHD animal model.Methods A total of 24 SHR were randomly divided into model group,tomoxetine group,Jingling oral liquid equal-dose group［11.15 g/（kg·d)］ and high-dose group［29.5 g/（kg·d)］,with 6 rats in each group,and 6 Wistar Kyoto rats (WKY) were included as control group.The improvement in working memory of the rats was observed by water maze after 6 weeks of treatment.The prefrontal lobes of the rats in each group were separated,and the structures of myelin sheath were observed by luxol fast blue（LFB）.The expressions of Nogo-A,MRF,FGF17,NG2 and MBP in the frontal lobe of rats were determined by western blot.Results （1） After 6 weeks of treatment,compared with the tomoxetine group,both the Jingling oral liquid equal-dose group and high-dose group demonstrated a more stable promotion of body weight gain in rats.（2）Compared with the model group,the finding time in water maze of SHR in tomoxetine group and Jingling equal-dose and high-dose groups was shortened after 6 weeks of treatment.（3） Compared with model group,myelin in brain tissues of rats in equal-dose and high-dose groups was tightly arranged with intact structure(P<0.05).（4） Compared with model group, NG2 and MRF protein expressions were increased in both Jingling oral liquid  equal-dose group and high-dose group，MBP expression was elevated in the high-dose group, while the FGF17 expression decreased in the equal dose-group, with all differences being statistically significant (P<0.05).Conclusion Jingling oral liquid can improve the memory and learning ability of SHR,and promote myelin regeneration and maturation. Related Articles | Metrics

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Analysis of the current status of clinical practice guidelines and diagnosis and treatment norms for children with pneumonia in recent 20 years WANG Bo, XIONG Lei, WANG Ziwei, BIAN Ji, YANG Shaoying, HE Xiying, MING Xi Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 39-44.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.008 Abstract （413）      PDF（pc） （1291KB）（460）       Knowledge map    Save By searching CNKI, China biomedical literature service system, Wanfang data knowledge service platform, Weipu Chinese science and technology journal full-text database, Pubmed, Embase and other databases, as well as Yimaitong, NICE,NGC,GIN and other websites, clinical practice guidelines and diagnosis and treatment norms for pediatric pneumonia were sorted out, and literature was independently screened by researchers. After extracting the data, the AGREE Ⅱ tool is used to evaluate the quality of the formulation methodology of the guidelines and diagnosis and treatment norms, and the recommended level is obtained, in order to grasp the formulation methods and quality status of clinical practice guidelines for childhood pneumonia at home and abroad, and to provide reference for the future formulation of high-quality clinical practice guidelines in professional fields. Related Articles | Metrics

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Current research status of the influence of dietary patterns on precocious puberty in children LIU Ziqi, ZHANG Guiju Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 17-22.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.004 Abstract （413）      PDF（pc） （1129KB）（998）       Knowledge map    Save When children enter puberty,they will experience prominent changes mainly in the morphology of their reproductive organs,and development of function and secondary sexual characteristics.The main manifestation of precocious puberty is the earlier development of secondary sexual characteristics and the premature maturation of sexual organs,which is an endocrine disease characterized by abnormal growth and development of children.With the development of economy and society,the advancement of the onset age of precocious puberty and the increase in incidence rate have triggered increasing social attention.Multiple factors can have an impact on precocious puberty,and modern researches have confirmed a correlation between the daily diet of children before puberty and precocious puberty.This article reviews domestic and foreign researches in common dietary patterns and various dietary nutrients related to adolescent sexual development in children,represented by high calorie diet patterns,Mediterranean diet patterns,and vegetarian diet patterns,and it summarizes the influence of different dietary patterns on precocious puberty in children.The article respectively summarizes the potential regulatory mechanisms of high protein diet,high-fat diet and high sugar diet in high calorie diet patterns,as well as the main dietary components (vegetables,fruits,olive oil,grains,nuts,beans,and dairy products) in Mediterranean diet patterns and vegetarian diet patterns in sexual development.The aim is to provide theoretical basis for the prevention and treatment of precocious puberty in children from the perspective of dietary intervention,and to provide new ideas for future researches on the relationship between dietary nutrition structure and sexual development. Related Articles | Metrics

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Research advances in the treatment of neurodevelopmental disorders in children with fecal microbiota transplantation HUA Zhichao, CHEN Yuyan, YANG Yufang, CHEN Xiaoling Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 22-26.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.005 Abstract （392）      PDF（pc） （1122KB）（587）       Knowledge map    Save Fecal microbiota transplantation (FMT), as a method to treat intestinal and extra-intestinal diseases by regulating intestinal flora dysbiosis, has attracted widespread attention in recent years. Its effect in the treatment of children's neurodevelopmental disorders (NDDs) has gradually been verified, showing great application prospects, which provides new strategies for the treatment of NDDs. This article explores its clinical efficacy, development prospects and some technical limitations that still exist at present by summarizing the relevant animal and clinical studies on FMT treatment for NDDs, aiming to provide relevant references for the subsequent clinical treatment of NDDs. Related Articles | Metrics

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Research on the clinical application of Zhimu-Huangbai in precocious puberty CHEN Na, LI Lianke, LU Yihong, YANG Yang, TAO Qiong, CHEN Zhu Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 8-12.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.002 Abstract （385）      PDF（pc） （1083KB）（568）       Knowledge map    Save Zhimu-Huangbai is a commonly used medicine pair in clinical practice,and the compatibility of the two drugs has the effects of nourishing yin and clearing heat,purging fire and detoxifying.Modern studies have found that Zhimu-Huangbai has anti-inflammatory,antioxidant,hypoglycemic,and lipidemic regulation effects because of its main active ingredients such as quercetin,kaempferol,barmatine,stigmasterol,mangiferin,berberine,etc.It is widely used in clinical practice,mainly for the treatment of precocious puberty,diabetes,diabetic nephropathy and other diseases in children.From the perspectives of chemical composition,pharmacological effects and clinical application,this paper expounds the application research of Zhimu-Huangbai in precocious puberty in recent years,in order to provide a theoretical basis for the scientific application of the drug in precocious puberty and for the research and development of new drugs. Related Articles | Metrics

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Clinical practice guidelines for integrative Chinese and western medicine in children with enuresis (2025) Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (3): 185-198.   DOI: 10.20274/j.cnki.1674-3865.2025.03.001 Abstract （360）   HTML （18）    PDF（pc） （1684KB）（98）       Knowledge map    Save Childhood enuresis (also known as nocturnal enuresis, NE) is intermittent urinary incontinence that occurs at night during sleep in children ≥5 years of age, and is one of the common clinical disorders in pediatrics. The persistent symptoms of nocturnal enuresis affect children's physical and mental health and quality of life, which aggravates social anxiety and increases the burden of family care. In order to standardize the clinical diagnosis and treatment protocols of NE in integrative Chinese and western medicine, the Chinese Society of Traditional Chinese Medicine (CSTCM) Children's Health Collaborative Innovation Platform (CHCIP), the Chinese Children's Enuresis Disease Management Collaborative Group of Renal Disease Group of Pediatricians Branch of Chinese Medical Doctor Association (CMDA), and the Kidney Rheumatism Endocrinology Cooperative Group of Pediatric Special Committee of Chinese Association of Integrated Traditional Chinese and Western Medicine have jointly initiated the development of this guideline. The guideline systematically sorts out NE from the aspects of definition, clinical classification, pathogenesis, medical history collection, physical examination, auxiliary examination, and diagnosis and treatment strategies of integrative Chinese and western medicine. Especially, it puts forward the integrative points of Chinese and western medicine regarding different clinical classifications of NE, with the aim of providing rationalized suggestions and references for the diagnosis and treatment of NE in both Chinese and western medicines, and promoting the development of the research on the combination of Chinese and western medicines in NE. Table and Figures | Reference | Related Articles | Metrics

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Treatment for pediatric pulmonary diseases based on the theory of "lungs governing skin and hair" and the method of "analogy and classification"  WEI Jiaxuan, YANG Jianhui, FENG Zhongfa, LI Rong, ZHAO Shun, LIU Qiaoya Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 75-78.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.016 Abstract （351）      PDF（pc） （1062KB）（765）       Knowledge map    Save This paper explores the application value of Traditional Chinese Medicine (TCM) theory of "lungs governing skin and hair" and the thinking method of "analogy and classification" in the treatment of pediatric pulmonary diseases.Both "lungs governing skin and hair" and "analogy and classification" are traditional TCM theoretical approaches guiding clinical differential diagnosis and treatment.By discussing the correlation between the lungs and the skin and hair,and then employing the method of analogy and classification,this paper explores the feasibility and efficacy of treating pulmonary diseases by the "skin"-cortex (the character of skin and cortex is the same in Chinese).Starting from the physiological characteristics of children,such as "lung deficiency" and loose cutaneous layers,the paper argues that "cortex-related" herbal medicines (e.g.,Baixian Pi,Hou Po,and Chan Tui) can improve the pathological features of being easily invaded by external pathogens in children.Through case studies,this paper demonstrates a formula containing cortex-related herbs in the treatment of cough (wind-phlegm obstructing the lung) in a 4-year-old child,which is very effective.The results confirm the clinical feasibility of this approach.By integrating traditional TCM theories with modern scientific validation,this paper provides new insights into the diagnosis and treatment of pediatric pulmonary diseases,highlighting the unique advantages of TCM in the field of pediatrics. Related Articles | Metrics

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Treatment for children with adenoid hypertrophy with Xiaoxian Sanjie potion:an analysis of some cases WANG Gehuan, CHEN Ziqin, ZHANG Xuerong Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 146-149.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.010 Abstract （334）      PDF（pc） （1698KB）（348）       Knowledge map    Save 1Hubei University of Traditional Chinese Medicine,Wuhan 430065,China;2Hubei Shizhen Laboratory,Wuhan 430065,China;3Hubei Provincial Hospital of Traditional Chinese Medicine,Affiliated Hospital of Hubei University of Traditional Chinese Medicine,Wuhan 430065,China Related Articles | Metrics

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Observation on the clinical efficacy of Xiaoer Dingchuan granule in the intervention of respiratory syncytial virus pneumonia(syndrome of phlegm-heat blocking the lung) LI Ruixue, WANG Xuefeng, TAN Chunying, MENG Bin, ZHANG Xiuying, WANG Hui, LI Zhaoyang Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 87-91.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.019 Abstract （325）      PDF（pc） （1122KB）（487）       Knowledge map    Save Objective To evaluate the clinical efficacy of Xiaoer Dingchuan granule in the intervention of respiratory syncytial virus pneumonia (syndrome of phlegm-heat blocking the lung) in children.Methods A total of 72 children with respiratory syncytial virus pneumonia (syndrome of phlegm-heat blocking the lung) admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Maternal and Child Health Hospital and Benxi Manzu Autonomous County Hospital of Traditional Chinese Medicine from June 2023 to June 2024 were selected as the study subjects,who were randomly divided into control group and observation group with 36 cases in each group.The control group received basic treatment,and the observation group received Xiaoer Dingchuan granule in addition to the treatment for the control group.After 7 days of treatment,the clinical efficacy,TCM syndrome efficacy,single symptom remission time,disappearance time and adverse reactions were compared between the two groups.Results After treatment,the clinical effect and TCM syndrome effect of the observation group were better than those of the control group.The remission time of wheezing,cough,gurgling with sputum and fever in the observation group was shorter than that in the control group,and the differences were statistically significant(P<0.05).No adverse events occurred in the observation group.One case in the control group had nausea and vomiting,which disappeared after treatment.Conclusion Xiaoer Dingchuan granule has a positive therapeutic effect in the treatment of respiratory syncytial virus pneumonia (syndrome of phlegm-heat blocking the lung);the clinical effect is good,accelerating the disappearance of symptoms,and clinical application safety is high,which is worthy of clinical promotion. Related Articles | Metrics

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Application of San Yin Zhi Yi in the treatment of children with cough variant asthma LIANG Chaoqi, LONG Hongyan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 79-83.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.017 Abstract （321）      PDF（pc） （1080KB）（651）       Knowledge map    Save Pediatric cough variant asthma (CVA) is a common chronic respiratory disease primarily characterized by chronic cough. The exact etiology of CVA is not yet fully understood, but it is widely believed that the progression of the disease is influenced by various pathological factors, and is closely related to the patient's individual constitution, seasonal changes, and regional environmental characteristics. Traditional Chinese medicine (TCM) categorizes CVA under "wind cough", "wheezing cough", and "spasmodic cough", and pediatric CVA is managed according to the principle of "San Yin Zhi Yi"(three-cause adaptation), which involves personalized adjustments of the treatment plan based on the patient's constitution, seasonal changes and regional environment, reflecting the holistic treatment concept and syndrome-differentiation treatment of TCM. Therefore, this article discusses the etiology and pathogenesis of pediatric CVA from the perspectives of both TCM and modern medicine, based on the TCM principle of "San Yin Zhi Yi". It comprehensively considers the impact of factors such as constitution, season and environment on the onset and progression of the disease, exploring the application of San Yin Zhi Yi treatment for pediatric CVA from the three aspects of adapting to the season, region and individual. The aim is to provide a better theoretical foundation and practical guidance for the future TCM treatment of pediatric CVA. Related Articles | Metrics

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Traditional Chinese medicine constitution analysis of children with attention deficit hyperactivity disorder (syndrome of heart and liver fire hyperactivity) ZHOU Min, WANG Minhua, LI Yaqun Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 54-58.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.011 Abstract （307）      PDF（pc） （1113KB）（721）       Knowledge map    Save Objective To explore the distribution of traditional Chinese medicine(TCM) constitution in children with attention deficit hyperactivity disorder(ADHD) (syndrome of heart and liver fire hyperactivity),and its relationship with symptoms and social function of the children.Methods A total of 70 children aged 7 to 14 years with ADHD (syndrome of heart and liver fire hyperactivity) were included in the study,who were treated in Yixing Traditional Chinese Medicine Hospital from January 2023 to May 2024.The TCM syndrome scoring,SNAP-Ⅳ and CGAS were used to evaluate the severity of the symptoms and the impact on social function of the children,and the TCM constitution distribution was divided according to the TCM constitution scale.Results TCM syndrome score was (18.54 ± 2.84) in ADHD children (syndrome of heart and liver fire hyperactivity).The average SNAP-Ⅳ score of the boys was (41.02±8.56),the average SNAP-Ⅳ score of the girls was (41.19±8.46),the average CGAS score of the boys was (63.12±6.83),and the average CGAS score of the girls was (63.75±6.65),which significantly affected the children′s social function and normal life activities; the severity of the disease was not related to gender(P>0.05).Unbalanced constitution was the main type of TCM constitution,totaling 42 cases (60%),and 28 cases (40%) were with balanced constitution.Among the children with unbalanced constitutions,the number of children with qi-stagnation constitution,yin-deficiency constitution and qi-deficiency constitution was the highest (≥10%); the children with yin-deficiency constitution had the longest course of disease ［(4.25±0.41) years］,and the children with balanced constitution had the shortest course of disease ［(1.74±0.33) years］.Conclusion The TCM syndrome score of the 70 children with ADHD(syndrome of heart and liver fire hyperactivity) in Yixing area included in this study is high,which has a significant impact on the social function of the children,but there is no gender difference.Unbalanced constitution is the main type in the distribution of constitution,and the disease course of ADHD (syndrome of heart and liver fire hyperactivity) is different in children with different constitutions. Related Articles | Metrics

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Professor Li Xinmin's experience in treating refractory nephrotic syndrome in children with the method of dredging and regulating the triple energizer CHEN Hongxiang, LI Xinmin, HAN Yaowei, QIN Luping Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 71-74.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.015 Abstract （300）      PDF（pc） （1059KB）（349）       Knowledge map    Save Refractory nephropathy in children is one of the difficulties that need to be urgently addressed in clinical practice. Based on years of clinical experience, Professor Li Xinmin believes that "dysfunction of the pivot of the triple energizer" is the core pathogenesis, and advocates the basic treatment principle of "dredging and regulating the qi movement of the triple energizer, with particular emphasis on the spleen and stomach in the middle energizer". Clinically, he is good at restoring the qi transformation of the triple energizer by coordinating the ascending and descending of the qi movement of the "lung, spleen, stomach and liver" thereby normalizing the water and fluid metabolism function. Meanwhile, he advocates treating the disease based on stages. In the acute recurrence stage, emphasis is placed on clearing and dispersing the lung qi in the upper energizer, and Yinqiao Silian decoction with modification is often used. In the remission stage, attention is paid to dredging and promoting the spleen and stomach in the middle energizer, and Weiling decoction with modification is commonly employed. In the protracted stage, focus is on dredging and regulating the qi movement of Shaoyang, and Chaihu Linggui Zhugan decoction with variation is often administered. Professor Sun Liping emphasizes moderation and balance in the prescription and medication, and he is particularly skilled in using the combination of bitterness with acridity to unfold and regulate the pivot. The clinical therapeutic effect is significant. Related Articles | Metrics

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Experience in the diagnosis and treatment of children's diseases from "accumulated internal heat" ZHANG Yu, XIAO Yang, ZHOU Mengxiao, SUN Liping Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 59-63.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.012 Abstract （291）      PDF（pc） （1073KB）（1306）       Knowledge map    Save The function of the spleen in children is often insufficient, and improper feeding, or disease damage may cause the fact that food can't be digested, which is food accumulation。Although it is a disease of the spleen, Professor Sun Liping believes that long time of food accumulation can form internal heat syndrome, thereby inducing a variety of pediatric diseases. Attention should be paid to the physical changes caused by congenital abnormality and acquired dystrophy. Based on the physiological and pathological characteristics of children, Yin and Yang theory, five-element theory and constitution theory, and through combination with more than 30 years of clinical experience of Professor Sun Liping, this paper explores the etiology and pathogenesis of children's diseases caused by "food", the disease outcome transformed by "heat", the diagnosis experience from "observation", and the treatment method by "elimination". A new line of thinking of "same treatment for different diseases" is provided for the diagnosis and treatment of abdominal pain, cough, asthma and tic disorders caused by food accumulation. Related Articles | Metrics

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Screening for malnutrition risks and analysis of influencing factors in children with pertussis YAN Xili, LIU Jing, HU Qiaomei, TAO Yuqiong Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 50-54.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.010 Abstract （290）      PDF（pc） （1077KB）（170）       Knowledge map    Save Objective To analyze the risk factors for malnutrition in children with pertussis.Methods Totally 124 children with pertussis hospitalized for treatment in Hunan Children′s Hospital from March 2023 to March 2024 were selected as the research subjects.The children were grouped according to whether they had malnutrition,and the indicators with statistical significance in the single factor were included in Logistic regression analysis.Results The malnutrition assessment score for 124 children with pertussis was (3.59±1.74),including 38 cases (30.65%) with malnutrition and 86 cases (69.35%) with normal nutrition.The results of Logistic regression analysis showed that age,severity of disease,presence of other diseases,uncertainty about disease,and sleep status were risk factors for malnutrition in the children (P<0.05).Conclusion Severe malnutrition exists in hospitalized children with pertussis,and low age,severe illness,comorbidities,high levels of uncertainty about disease in family members and poor sleep conditions are all independent risk factors for malnutrition in children.Scientific and reasonable feeding should be carried out to reduce the incidence of malnutrition in children. Related Articles | Metrics

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Meta analysis and GRADE evaluation of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia WU Pan, HUANG Tingyue, ZHANG Zhanling, WANG Xuefeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 98-108.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.002 Abstract （287）      PDF（pc） （7421KB）（136）       Knowledge map    Save Objective:To systematically evaluate the efficacy and safety of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia.Methods:Randomized controlled trials of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia published in Chinese databases and English databases,including CNKI,Wanfang,VIP,CBM,Pubmed,Cochrane Library and Embase,were searched for by computer and the relevant grey literature was traced.Two researchers conducted literature screening and data extraction separately,and conducted quality evaluation of the included studies.The meta analysis and evidence quality evaluation were carried out using RevMan 5-4 software and GRADE system respectively.Results:A total of 16 studies were included,involving a total of 1 503 patients,752 patients in the experimental group and 751 patients in the control group.The results of meta analysis showed that the total effective rate,the antipyretic time,the disappearance time of cough,the disappearance time of sputum,the disappearance time of lung rales,CRP level,IL6 level and TNFα level were better by Xiaoer Feire Kechuan oral liquid than by conventional western medicine in the treatment of Mycoplasma pneumoniae pneumonia,and the incidence of adverse reactions was not increased.The grading results of GRADE evidence showed that the evidence of total effective rate,the disappearance time of sputum and the incidence of adverse reactions was the low grade;the evidence of antipyretic time,the disappearance time of cough and the disappearance time of lung rales,inflammatory indexes(CRP,IL6,TNFα） and lung function（FEV1,FEV1/FVC,MVV） was the very low grade.Conclusion:The therapeutic effect of Xiaoer Feire Kechuan oral liquid on Mycoplasma pneumoniae pneumonia in children is definite,and its safety is superior to conventional western medicine treatment. Related Articles | Metrics

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Effects of human milk oligosaccharides in breast milk on intestinal flora of infants and research progress LI Jianying, XUE Lingyan, HE Chunlan, ZHAO Lingli Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 121-125.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.005 Abstract （286）      PDF（pc） （1259KB）（391）       Knowledge map    Save Human milk oligosaccharides (HMOs) in breast milk can effectively promote the growth and colonization of beneficial bacteria in the infant's intestinal tract and inhibit the invasion of pathogenic bacteria.By improving the composition of the infant's intestinal flora and increasing the abundance of the intestinal flora,it maintains the health of the intestinal tract and enhances the immune system of infants,and also has an significant preventive effect on intestinal dysfunction related diseases.This article mainly expounds the research progress in the correlation between HMOs and the infant's intestinal flora in recent years,summarizes the influence of factors such as the mother's genotype on HMOs in the mother's body,and further explores the promoting effect of HMOs on the infant's intestinal flora,which is of great significance for better restoring the nutritional components of breast milk for feeding and preventing related diseases. Related Articles | Metrics

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Analysis of risk factors for hyperuricemia in children of different ages FANG Yanying, GAN Jiahui, XU Yuyin, XU Ziying, SITU Meiling, YU Shujuan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 45-49.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.009 Abstract （286）      PDF（pc） （1099KB）（405）       Knowledge map    Save Objective To measure serum uric acid(SUA) levels in children of different ages(0 to 14 years),investigate the incidence of high level of uric acid in those regions,and analyze its association with gender,age,body size-body mass index(BMI),and living habits［including consumption of seafood,consumption of long-boiled soup/stew,consumption of vegetables,consumption of beverages,consumption of sweets,daily water intake(mL) and daily exercise (min)］.Methods Totally 1 209 children visiting Kaiping City Centre Hospital and Kaiping Maternal and Child Health Hospital from January 2022 to September 2023 were enrolled in the study.Height/length,weight and SUA of the children were measured,and the children were grouped according to age and gender in order to investigate the SUA levels of children in different age groups and genders.In addition,the children were grouped according to the SUA level to investigate the current situation of uric acid and the incidence of hyperuricaemia in the region.In the meantime,the relationship between hyperuricaemia(HUA) in the children and their gender,age,body size-BMI and living habits were also investigated.Results The distribution of SUA levels showed no statistically significant difference between different genders(P>0.05). In children of different ages and body types, SUA levels exhibited a trend of gradual increase with age and body type growth. The overall detection rate of hyperuricemia was 20.18%(244/1 209), and the comparison of the detection rates of hyperuricemia between different genders showed no statistically significant difference(P>0.05). However, the comparison of hyperuricemia detection rates among different ages and body types showed statistically significant differences(P<0.01). Logistic regression analysis revealed that seafood consumption, beverage intake, and a preference for sweet foods were risk factors for hyperuricemia, while increased vegetable intake, fluid consumption, and appropriate exercise were protective factors for uric acid levels. Conclusion The level of SUA in children in Kaiping City increases with age and changes in body type, with no specific relation to gender; high-purine and high-sugar foods are risk factors for hyperuricemia. Related Articles | Metrics