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Experimental research into the influence of Yiqi Guben capsule on the spleen lymphocyte proliferation function and organ index in the kidneyYang deficiency asthma model mice.
CHEN Yueyuan,SUN Liping.
Chinese Pediatrics of Integrated Traditional and Western Medicine
2013, 5 (1):
12-16.
DOI: 10.3969/j.issn.1674-3865.2013.01.004
Objective:To observe the influence of Yiqi Guben capsule on the spleen lymphocyte proliferation function and organ index in the kidneyYang deficiency asthma model mice and to explore its clinical significance.MethodsTotally 96 mice were randomly divided into seven groups: normal control group, asthma group, the kidneyYang deficiency asthma group, kidneyqitonifying pill group, the Yiqi Guben capsule lowdose group, middledose group, highdose group. Apart from the asthma group consisting of 12 mice, the remaining groups each consisted of 14 mice(male and female in half). kidneyYang deficiency asthma groups were treated with Yiqi Guben capsule. Recorded changes in the general condition of the mice in each group during modeling and the period of administration, such as, body weight, body temperature and activity, hair color, diet, breathing frequency, etc. After the experiment, took the spleen and examined the lymphocyte proliferation function; took the kidney, spleen and thymus, and weighed them and calculated the organ coefficient.ReslutsIn the Yiq Guben capsule group and kidneyqitonifying pill group, the mice weight and thymus weight were significantly higher than the kidneyYang deficiency asthma group; in the Yiqi Guben capsule middledose group, the highdose group and kidneyqitonifying pill group, the spleen lymphocyte proliferation by LPS stimulation was significantly higher than the kidneyYang deficiency asthma group.ConclusionYiqi Guben capsule can significantly improve the general state of the kidneyYang deficiency asthma mice, restore immune organ weights, and improve the function of the spleen lymphocyte proliferation.
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