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Exploring the treatment for short stature in children with "the method of nourishing the spleen" based on the theory of "the spleen governing the four internal organs DONG Dan, LI Ying, WANG Xuefeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 387-391.   DOI: 10.3969/j.issn.1674-3865.2024.05.006 Abstract （140）      PDF（pc） （1048KB）（689）       Knowledge map    Save The causes of short stature in children can be summarized as insufficient innate endowment or improper postnatal nourishment. The spleen is the source of life after birth, and when the spleen is healthy, the nutrients it generates can be distributed throughout the body, providing sufficient material basis for the internal organs and abundant qi and blood, allowing normal growth and development of children. On the other hand, if the spleen and stomach functions are impaired, the source of qi and blood generation is lacking, which affects other organs and causes dysfunction of other internal organs, leading to delayed growth and development in children. Additionally, children have the physiological state and constitutional feature of "spleen often being insufficient". Therefore, treating childhood short stature based on the spleen is of great significance. Taking "nourishing and strengthening the spleen" as the basic treatment principle and based on the theory of "the spleen governing the four internal organs", the author lists eight common Chinese medical syndrome types: spleen deficiency, spleen deficiency with food stasis, spleen deficiency with dampness, spleen deficiency with liver hyperactivity, spleen- and stomach-yin deficiency, lung- and spleen-qi deficiency, spleen and kidney deficiency, and heart and spleen deficiency. This paper summarizes the experience in the differentiated treatment of short stature in children based on the basic formula of Sijunzi soup, aiming to provide clinical references for the treatment of short stature in children with traditional Chinese medicine. Related Articles | Metrics

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Discussion on the influence of Wan Quan′s "Four methods of infant rearing" on the growth and development of children FENG Zhongfa, YANG Jianhui, SU Yanyan, WEI Jiaxuan, TAO Qiong, DU Li Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 395-398.   DOI: 10.3969/j.issn.1674-3865.2024.05.008 Abstract （170）      PDF（pc） （1050KB）（611）       Knowledge map    Save Wan Quan has proposed the "Four methods of infant rearing":pre-raising to cultivate origin,fetal raising to ensure health,peripartum raising to prevent changes,and postpartum raising to be alert to diseases-The method of pre-raising to cultivate origin involves preparing for pregnancy,avoiding harm,and ensuring a healthy birth-The method of fetal raising to ensure health means that parents should focus on mental adjustment,moral cultivation,diet and daily habits,exercise,and fetal education to ensure the healthy development of the fetus-The method of peripartum raising to prevent changes includes care for the child,disease prevention and control,and care for the mother′s body from the neonatal period to the infant period-The method of postpartum raising to be alert to diseases includes daily care,diet and nutrition,disease prevention,and early education from early childhood to the early school age-Fully exploring the implications of Wan Quan′s "Four methods of infant rearing" theory and connecting it with the growth and development of children has certain referential significance for the upbringing of children today Related Articles | Metrics

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Treatment for childhood short stature based on "Yang transforming qi and yin shaping stature" TONG Tingting, ZHANG Guiju Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 392-394.   DOI: 10.3969/j.issn.1674-3865.2024.05.007 Abstract （150）      PDF（pc） （1048KB）（558）       Knowledge map    Save Childhood short stature is mostly caused by insufficient cong enital endowment and improper nutrition later on, and the key pathogenesis is the spleen and kidney insufficiency. At present, recombinant human growth hormones are used most often for the treatment of short stature in western medicine, and the treatment plan is relatively simple. Traditional Chinese medicine(TCM) has obvious effects in the treatment of short stature based on syndrome differentiation, which can effectively improve children's growth rate and regulate physical fitness. Based on the clinical experience of Professor Zhang Guiju and the theory of "Yang transforming qi and yin shaping stature" it is believed that childhood short stature is closely related to the insufficiency of "Yin shaping stature". Yin essence plays an important role in the growth and development of the human body. Children can gradually grow taller and stronger if the function of "Yin shaping stature" is normal. On the contrary, insufficiency in "Yin shaping stature" will lead to delayed growth and short stature in children. Therefore, in the treatment of childhood short stature, it is necessary to add yin-nourishing Chinese medicines based on syndrome differentiation, such as Radix rehmanniae praeparata, Cornus officina, yam, Fructus lycii, Polygonatum kingianum, Polygonatum odoratum, lily, etc. Such medicines contain a variety of effective ingredients, which can not only supplement the nutrients needed by the human body, but also have a variety of effects such as regulating immunity and protecting the internal organs. In addition, spleen-strengthening and digestion-assisting drugs should be added to the prescription to protect the spleen and stomach and prevent getting too greasy. Related Articles | Metrics

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Traditional Chinese medicine understanding of short stature in children and syndrome differentiation and treatment for the disease WANG Xuefeng, ZHANG Xiuying Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 380-383.   DOI: 10.3969/j.issn.1674-3865.2024.05.004 Abstract （263）      PDF（pc） （1026KB）（446）       Knowledge map    Save Because children with short stature are shorter than children of the same age,they may suffer from low self-esteem,which seriously affects their mental health and has different degrees of impact on their future learning and lives.Traditional Chinese medicine has some advantages in the treatment of this disease because its syndrome differentiation and treatment can improve the growth and development of children.This paper first sorts out the historical development of short stature,which,as an independent name of the disease,was firstly seen in the textbook of Integrated Traditional Chinese and Western Medicine Pediatrics edited by Prof.Wang Xuefeng.Then,the etiology and mechanism of short stature are summarized.Its etiology is the deficiency of innate endowment and the lack of nutrition in later life.The disease is located in the spleen and kidneys,and it is closely related to the heart,liver and lungs. The nature of the disease is mostly deficiency.The primary mechanism of the disease is the deficiency of the five organs and the deficiency of essence and qi.The basic treatment principle is determined again,which is to support the spleen and nourish kidneys and also to take into account other organs.Among the treatment methods,the method of tonifying the kidneys and nourishing the liver is suitable to those with deficiency of yin in the liver and kidneys and loss of nourishment of the muscles and bones;the method of supporting the spleen and strengthening the stomach is suitable to those with weakness of the spleen and stomach and deficiency of qi and blood;the method of nourishing the kidneys and clearing the heart is suitable to those with deficiency of the heart and kidneys and imbalance of water and fire;the method of strengthening the spleen and nourishing the lungs is suitable to those with deficiency in the lungs and spleen and loss of qi of the mother;the method of warming and tonifying the kidney-yang is suitable to those with insufficiency of the kidney-yang and dysfunction of warming.Finally,the strategy of multi-dimensional care and prevention before the onset of disease is put forward.For children with short stature,attention should be paid to balanced nutrition,moderate increase in exercise,reasonable arrangement of sleep,and adjustment of the body in line with the four seasons. Related Articles | Metrics

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Expert consensus on the diagnosis and treatment of pharyngitis and tonsillitis in children WANG Xuefeng, SHANG Yunxiao, XIONG Lei, ZHANG Jianhua, QIN Yanhong, LIU Changshan, ZHANG Baoqing, CAO Ling, XU Hua, WANG Lining, YANG Nan, LI Miao, YANG Yungang, ZHANG Xiuying Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 399-403.   DOI: 10.3969/j.issn.1674-3865.2024.05.009 Abstract （289）      PDF（pc） （1047KB）（363）       Knowledge map    Save Pharyngitis and tonsillitis are common respiratory infectious diseases in childhood,and are highly prevalent in spring and fall.They can be categorized into acute and chronic stages.The acute stage is characterized by rapid onset and progression of the disease,and in severe cases,hoarseness and even respiratory difficulties may occur.In the chronic stage,the disease is prolonged due to the lack of proper treatment.Repeated pharyngitis and tonsillitis can lead to voice changes in children.At present,there are not many western medicines that can effectively treat childhood pharyngitis and tonsillitis,which are mainly antibiotic drugs,and although there are many types of traditional Chinese medicines used to clear the throat,western pediatricians are not standardized in the selection,syndrome differentiation and application of traditional Chinese medicines.Therefore,it is particularly important to explore the treatment for pharyngitis and tonsillitis in children with integrated Chinese and western medicine.This consensus firstly systematizes the Chinese and western medical understanding of pharyngitis and tonsillitis in children;secondly,it discusses its staging,etiology and main risk factors;thirdly,it clarifies its diagnostic criteria;finally,it gives a detailed elaboration on the principle of integrated Chinese and western medicine treatment for pharyngitis and tonsillitis in children and the Chinese and western medicine treatment methods.This consensus provides Chinese and western pediatricians,especially western physicians,with ideas on integrated Chinese and western medicine treatment,and further standardizes the rational selection and application of Chinese and western medicines. Related Articles | Metrics

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Diagnosis and treatment guideline for functional dyspepsia in children with the integrated traditional Chinese and western medicine WANG Xuefeng, WU Jie, GONG Sitang, XIONG Lei, JIANG Mizu, WANG Baoxi, XU Hua, PENG Yu Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 461-468.   DOI: 10.3969/j.issn.1674-3865.2024.06.001 Abstract （264）      PDF（pc） （1049KB）（342）       Knowledge map    Save Functional dyspepsia,as one of the most common functional diseases of upper digestive tract,seriously affects the quality of life and growth and development of children in China.Due to the changing definition and symptom spectrum of functional dyspepsia in children,its diagnosis and treatment are controversial.In order to standardize the diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine,and effectively solve the clinical problems in the diagnosis and treatment of children with functional dyspepsia,this guideline is formulated to guide the standardized diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine. Related Articles | Metrics

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Application of external treatment of Chinese medicine in children's growth and development WANG Lining, SUN Kexing, LIANG Yi Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 384-387.   DOI: 10.3969/j.issn.1674-3865.2024.05.005 Abstract （252）      PDF（pc） （1006KB）（340）       Knowledge map    Save Short stature and not-up-to-standard stature belong to the category of "Wu Chi" and "Wu Ruan" in Chinese medicine, and Chinese medicine believes that the pathogenesis of them is deficiency in the spleen and kidney, which gets the heart and liver involved. External treatment of Chinese medicine is a unique natural and green therapy under the guidance of Chinese medicine theory, which has certain advantages in the treatment of short stature and not-up-to-standard stature. This article summarizes the treatment methods such as massage, acupuncture, moxibustion and acupoint application, as well as the mechanism of external treatment of Chinese medicine for children with short stature and not-up-to-standard stature, with a view to guide the early and timely clinical intervention, improve the function of children's internal organs and promote their growth and development. Related Articles | Metrics

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Rehabilitation evaluation and treatment progress of hypotonia in infants and young children XU Haofan, ZHONG Zengquan, LAI Yanmei, LI Wei, ZHANG Xin, LI Hong, YANG Fan, LI Yiming, LYU Zhihai Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 414-419.   DOI: 10.3969/j.issn.1674-3865.2024.05.012 Abstract （218）      PDF（pc） （1091KB）（324）       Knowledge map    Save Hypomyotonia accompanied by growth retardation is an early symptom and sensitive sign of global developmental delay(GDD) in infants and young children,and is one of the early clinical manifestations of neurodevelopmental disorders and genetic metabolic diseases,which has a high incidence rate.According to the location of neuromuscular damage and involvement,hypotonia can be divided into three types:central hypotonia(CH),peripheral hypotonia(PH),or mixed hypotonia(MH).On the basis of etiological diagnosis of hypotonia,clinical evaluation and rehabilitation evaluation are conducted.Rehabilitation evaluation includes assessment of motor development level,developmental evaluation,evaluation of communication ability,and evaluation of daily life activity ability.Under the theoretical framework of the international classification of functioning,disability,and health(children and youth edition)(ICF-CY),the methods such as exercise therapy,traditional Chinese medicine rehabilitation,neuromuscular electrical stimulation,intramuscular patches,and assistant braces are adopted to promote the development of anti-gravity postures.Based on function-orientation and with the goal being to continuously improve activity and participation abilities,environmental factors such as rehabilitation aids are used to modify and improve the ability of daily life activities. Related Articles | Metrics

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Experience and reflection on traditional Chinese medicine treatment for precocious puberty in children and impaired height XIONG Lei, HE Xiying, CAO Ting Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 377-379.   DOI: 10.3969/j.issn.1674-3865.2024.05.003 Abstract （253）      PDF（pc） （1016KB）（312）       Knowledge map    Save The clinical manifestation of precocious puberty is the premature development of secondary sexual characteristics, which can cause increased growth rate, rapid skeletal maturation, premature epiphyseal closure, etc. If not treated in time, it may cause children to be short in adulthood and increase the risk of endocrine diseases. Gonadotrophin releasing hormone analogue is the first choice in the treatment of this disease in western medicine, which can significantly inhibit the sexual development process by regulating the hypothalamicpituitarygonadal axis, but there is still controversy in terms of benefits to children's height. Traditional Chinese medicine therapy has been proven to be safe and effective in improving children's symptoms, regulating sex hormone levels, delaying gonadal development, improving height impairment, and increasing adult height. Professor Xiong Lei believes that the core pathological mechanism of this disease is kidneyyin deficiency and hyperactivity of liveryang fire. The treatment should be nourishing yin to strengthen the root, and lowering fire to clear sources. At the same time, for the patients with stagnated heat of liver channel, the method of dispersing stagnatedliver qi and clearing fire is used; for those with internal retention of phlegmdampness, the method of invigorating spleen to dissipate phlegm is used; for those with disharmony in the middle jiao, the method of invigorating spleen and harmonizing stomach is used. For children with rapid progression, gonadotrophin releasing hormone analogue can be used at the same time; for children with growth retardation and height impairment, recombinant human growth hormone should be considered to maximize their benefits to the height. Related Articles | Metrics

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Experience in the treatment of post-infection cough in children with dampness-heat constitution by "decomposition,diaphoresis,purgation and diuresis" LI Ruibing, SUN Liping Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 537-539.   DOI: 10.3969/j.issn.1674-3865.2024.06.017 Abstract （93）      PDF（pc） （952KB）（298）       Knowledge map    Save Post-infection cough is a common illness in children,and it is persistent and difficult to be cured.Based on the characteristics of children′s physique,Professor Sun Liping points out that the dampness-heat constitution factors run through the whole process of post-infection cough of children,so in the treatment Prof.Sun advocates the way of "decomposition,diaphoresis,purgation and diuresis" on the basis of the treatment for cough in order to improve the dampness-heat constitution and accelerate the recovery of children.In clinical practice,the treatment is mainly based on the syndrome differentiation of dampness and heat accumulated in lungs and dampness and heat damaging yin,and Sanren decoction combined with Zhike powder and Bufei powder with modification are used,which usually has good results. Related Articles | Metrics

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A study on adolescent depression based on the theory of five spirit viscera LIU Yan, WANG Hai Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 458-460.   DOI: 10.3969/j.issn.1674-3865.2024.05.021 Abstract （128）      PDF（pc） （1008KB）（292）       Knowledge map    Save Adolescent depression is a common mental and psychological disorder in adolescence,and although its symptoms have their own characteristics,it is inseparable from the overall theory of Chinese medicine in terms ofetiology and pathogenesis.Based on the theory of the five viscera and the analysis of the "five viscera","five spirits" and "five elements",this paper explores its correlation with the occurrence of depression in order to perform differential treatment,which provides a new direction for the treatment of depression in TCM and enriches the treatment system of emotional diseases in TCM. Related Articles | Metrics

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Treatment experience of functional dyspepsia in children by the "Spleen regulation and mediation method" of the Huang's Pediatric School in central Guizhou Province PENG Yu, WU Min, LIU Qiyan, CHEN Zhu, SUN Haipeng, YANG Jianhui, LENG Li, PANG Ping, YE Qian Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 468-472.   DOI: 10.3969/j.issn.1674-3865.2024.06.002 Abstract （147）      PDF（pc） （996KB）（272）       Knowledge map    Save Functional dyspepsia (FD) is a common digestive disorder among children. Clinically, it is primarily characterized by postprandial fullness, early satiety, upper abdominal pain, or a burning sensation in the upper abdomen. It may also be accompanied by symptoms such as belching, acid regurgitation, nausea, vomiting, poor appetite, and abdominal distension, presenting a wide range of manifestations. FD is prone to recurrence and has a relatively prolonged course. According to its main symptoms, it is categorized into conditions such as "abdominal pain," "abdominal distension," "epigastric fullness," and "vomiting" for syndrome differentiation and treatment in traditional Chinese medicine (TCM). The etiology of FD is often attributed to improper diet or post-illness disorders, with the pathogenesis being dysfunction in the ascending and descending mechanisms of the spleen and stomach qi. In Huang's Pediatric School of central Guizhou Province, it is believed that whether it is deficiency or excess, "the failure of the spleen to transport and regulate" is the key to the pathogenesis of pediatric FD, and it is also the core pathogenesis of the symptoms such as "epigastric fullness, distension, and pain." In clinical practice, the severity of symptoms, duration of the disease, and characteristics of the nasal root and eyelids are assessed to determine the nature of the syndrome, including cold, heat, deficiency, and excess. Thus, the "Spleen regulation and mediation method" is established, and the "Spleen-regulating and Fullness-relieving powder" is used for syndrome-differentiated treatment, aiming to rapidly restore the "spleen-transporting" function in children with FD and achieve the state of the spleen "regulating the qi of the four viscera," which provides a clinical reference for TCM treatment of pediatric FD. Related Articles | Metrics

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Studies on short stature in Chinese and western medicine and the prospects YU Jian, WANG Na Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 372-376.   DOI: 10.3969/j.issn.1674-3865.2024.05.002 Abstract （316）      PDF（pc） （1076KB）（259）       Knowledge map    Save Short stature is affected by many congenital and acquired environmental factors, which involves every stage from pregnancy to adolescence. From the perspective of integrated Chinese and western medicine, this article systematically summarizes the definition and epidemiological features of short stature in clinical practice, as well as its diagnosis and treatment strategies in Chinese and western medicine. It is emphasized that a comprehensive intervention should be performed in order to scientifically cope with the issues on children's growth and development, especially short stature, which includes life style adjustment, nutritional regulation, exercise and sleep management. Researches have shown that the integrated Chinese and western medicine therapy can not only increase the growth rate of children's height effectively, but also adjust the constitution of children in a comprehensive way, which improves the general health level of children. This article aims to provide theoretical support and practical reference for future clinical management of short stature and not-up-tostandard stature. Related Articles | Metrics

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Research progress on external treatment of traditional Chinese medicine for children with sleep disorders LIU Wen, GUAN Lijun Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 410-413.   DOI: 10.3969/j.issn.1674-3865.2024.05.011 Abstract （219）      PDF（pc） （1030KB）（248）       Knowledge map    Save Sleep disorders have gradually become one of the common diseases in children,and sleep quality is very important for children′s growth and development.Traditional Chinese medicine has achieved remarkable results in the treatment of sleep disorders in children.Because of its safety,reliability,having no adverse reactions and simple operation,TCM external treatment is easy to be accepted by parents.This paper systematically sorts out the commonly used external treatment methods of Chinese medicine for children with sleep disorders,including acupuncture,acupoint application,massage and transcranial magnetic therapy,etc.,and summarizes and studies the relevant literature of these methods. Related Articles | Metrics

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Paying attention to the standardized diagnosis and treatment for children with short stature LUO Xiaoping, WU Wei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 369-371.   DOI: 10.3969/j.issn.1674-3865.2024.05.001 Abstract （267）      PDF（pc） （1010KB）（241）       Knowledge map    Save Short stature has a significant impact on the physical and mental health of children, and it is a common disease in the endocrine department of pediatrics. Due to the rapid changes in children's growth and development and the complex etiology of short stature, there have always been such issues as missed diagnoses, misdiagnoses and insufficient intervention or overtreatment. This necessitates the strengthening of standardized diagnosis and treatment. This article discusses the challenges faced in the clinical diagnosis and treatment of children with short stature, especially emphasizing two aspects: one is to find out the etiology and make precise diagnosis, and the other is to perform individualized treatment strictly based on the indications. Meanwhile, the future direction of diagnosis and treatment of short stature is prospected, and suggestions are put forward for further standardization of diagnosis and treatment behavior of short stature, in order to provide useful reference for clinicians and policy makers. Related Articles | Metrics

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Mechanism of inflammation in simple obesity and the treatment progress in Chinese and western medicine NIU Changmiao, YAN Xiaoning, YIN Yongkai, LIANG Liting Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 404-409.   DOI: 10.3969/j.issn.1674-3865.2024.05.010 Abstract （186）      PDF（pc） （1081KB）（238）       Knowledge map    Save Simple obesity refers to the fact that the body′s intake of energy is greater than the consumption of energy,which is accumulated in the body in the form of fat,resulting in the main clinical manifestation of obesity,and it can be accompanied by abnormal metabolism of glucose and lipid and endocrine disorders.Its incidence is increasing year by year,and it has become a serious social public health problem.Simple obesity is a chronic low-grade inflammatory state,and its mechanism is closely related to endoplasmic reticulum stress,mitochondrial dysfunction,oxidative stress,and macrophage polarisation in the body.For this disease,both Chinese medicine and western medicine have their intervention and treatment means,but modern medicine believes that the treatment for obesity is a combination of dietary and nutritional structural adjustment,exercise,psycho-psychological and medication,which requires a high level of execution and compliance of the patient,and the medication also has obvious side effects.Chinese medicine has a unique theoretical understanding of obesity,and Chinese medicine treatment also has its unique advantages.In this paper,we will make a review of the mechanism of adipose tissue inflammation in simple obesity and the current status of Chinese and western medicine treatment. Related Articles | Metrics

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Research progress in the treatment of pediatric diseases with Traditional Chinese Medicine Hot Ironing CHEN Kezhu, ZHANG Wei Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 485-488.   DOI: 10.3969/j.issn.1674-3865.2024.06.006 Abstract （142）      PDF（pc） （979KB）（238）       Knowledge map    Save With the development of traditional Chinese medicine(TCM) in the field of pediatrics，the TCM external treatment methods have become more and more important in the treatment of pediatric diseases. TCM Hot Ironing, as one of them, through the inheritance and development of doctors of various generations as well as the combination with modern medicine and innovation, has been gradually progressing from daily health care to clinical treatment. Through the discussion of its historic evolution, mechanism of action and clinical application, this article explores the feasibility and rationality of TCM Hot Ironing in pediatric field. and sorts out the relevant literature on its actual clinical application, so as to provide theoretical support and clinical application reference for its further development in the field of pediatrics. Related Articles | Metrics

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Wang Youpeng′s experience in treating pediatric eczema in cold regions based on the theory of "Interaction between Lung and Large Intestine" LIN Yuzhen, WANG Yijie, WU Honghui, QIN Wen, LIU Lujia, WANG Youpeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 540-543.   DOI: 10.3969/j.issn.1674-3865.2024.06.018 Abstract （112）      PDF（pc） （976KB）（233）       Knowledge map    Save Pediatric eczema is a common inflammatory skin disease in clinic,and the unique geographical and cultural environment of cold regions leads to repeated bouts of eczema,which seriously affects the physical and mental health of the children and their quality of life.This paper summarizes the experience of Professor Wang Youpeng in treating pediatric eczema in cold regions based on the theory of "Interaction between Lung and Large Intestine".The causes and mechanisms of pediatric eczema are concluded as wind-evil retention,dampness-heat accumulation in the intestine and internal organs,and excessive dryness and insufficient fluid.In the clinical treatment of pediatric eczema,the method of dispersing wind and dispelling evil,eliminating and dispersing,and nourishing yin and moistening dryness is used,which has achieved significant effect.A case is given here to provide a new idea for the TCM diagnosis and treatment of eczema in cold regions. Related Articles | Metrics

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Individualized intervention strategies in the treatment of childhood and adolescent obesity based on precision medicine LI Ping, YANG Fan, LIU Hanmin Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 1-7.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.001 Abstract （204）      PDF（pc） （1165KB）（231）       Knowledge map    Save Childhood and adolescent obesity has become a global challenge in public health.Its high weight regain rate and risks of metabolic complications highlight the limitations of traditional intervention strategies.This review systematically explores individualized intervention strategies for obesity in children and adolescents in the context of precision medicine,breaking the traditional "one-size-fits-all" model.It integrates multi-omics technologies with intelligent management methods,proposing a multidimensional framework for precise intervention.First,a precise diagnosis and evaluation system is constructed based on multi-modal data,including genomics,radiomics,and gut microbiomics,to identify genetic susceptibility,metabolic phenotypes and microbiome characteristics,laying the foundation for stratified interventions.Secondly,individualized intervention plans are developed based on genetic risk scores,epigenetic regulatory mechanisms,and gut microbiome-targeted therapies:gene-guided strategies aim to optimize dietary structure through multi-gene risk assessments; epigenetic interventions aim to regulate DNA methylation and histone modification by taking advantage of nutrients (such as methyl donors and short-chain fatty acids),reversing metabolic dysregulation; microbiome remodeling aims to improve energy metabolism balance through probiotics and synbiotics.Furthermore,artificial intelligence and wearable devices are employed for dynamic monitoring in multiple scenarios.By collaborating with multidisciplinary teams in nutrition,sports medicine,and psychology,a smart management model of "hospital-family-community" network is established.While precision medicine offers groundbreaking directions for childhood obesity treatment,challenges such as biomarker validation,data integration,and long-term efficacy evaluation remain to be addressed.This review provides theoretical foundations and practical pathways for the improvement in the effectiveness and sustainability of interventions,emphasizing the need to integrate interdisciplinary innovative technologies in the future in order to promote the transformation of childhood obesity management toward precision and intelligence. Related Articles | Metrics

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Analysis of intestinal flora of girls with central precocious puberty WANG Ge, ZHANG Xuerong, LIU Yanyun, DUAN Yunyan, SHEN Hexiao Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (5): 419-424.   DOI: 10.3969/j.issn.1674-3865.2024.05.013 Abstract （125）      PDF（pc） （1723KB）（216）       Knowledge map    Save Objective：To analyze the diversity,structure and functional characteristics of the intestinal flora of girls with central precocious puberty (CPP),and to explore the differential flora and potential functions of them with those of healthy girls of the same age.Methods：We selected 20 girls who attended the pediatric outpatient clinic of Hubei Provincial Hospital of Traditional Chinese Medicine from November to December 2023 and were diagnosed with CPP as the CPP group,and 20 healthy girls volunteers of the same age during the same period were included as the control group.Stool samples were collected for 16S rRNA sequencing to analyze the differences in the composition,structure and function of the intestinal flora between the two groups.Results：The difference in α-diversity of intestinal flora between the two groups was not statistically significant (P>0.05).The β-diversity of intestinal flora in the CPP group showed a clear tendency to segregate,and the difference between the two groups was statistically significant (P<0.05).Genes in the CPP group were enriched for endocrine and metabolic disorders,nucleotide metabolism,amino acid metabolism,cellular processing,and signal transduction.Conclusion：Differences between girls with CPP and healthy girls are not significant in terms of the number,species diversity,and distributional homogeneity of intestinal flora,but there are significant structural differences;the functions in predicting endocrine and metabolic diseases,nucleotide metabolism,amino acid metabolism,cellular processing,and signaling are potentially correlated with CPP. Related Articles | Metrics