Abstract:
Objective
To study the factors that may affect the clinical treatment effect and the prognosis in children with acute lymphoblatic leukemia combined with varicella infection, and to provide evidence for designing the treatment plan for these children.
Methods
A total of 29 children with acute lymphoblastic leukemia combined with varicella infection were selected as the research subjects, who received treatment in the Infection Department of Hunan Children's Hospital from Feb. 2014 to May 2017. Compare the differences in the following items among children with different treatment outcomes: gender, age, course of disease, the interval between the onset of first symptom and admission to hospital, the chemotherapy history and the WBC count on admission.
Results
After treatment, 8 of the 29 children died, and there average age was (6.38±1.41)years. The other 21 children were cured, with an average age of (6.43±2.18)years. There was no statistical difference in age between them(P＞0.05).The average course of disease was (27.00±6.82) months in the dead cases, while it was (21.76±5.99) months in those cured, the difference being of no statistical significance(P>0.05).The interval between the onset of first symptom and the admission to hospital was (60.50±42.65)h in the dead children, which was significantly higher than that in the children cured［﹙14.33±12.25﹚h］,and there was statistical difference(P＜0.05).The incidence rate of repeated infection during chemotherapy and the WBC count on admission in the dead children were higher than those in the children cured, the difference being statistical(P＜0.05).
ConclusionThe main factors that affect the clinical treatment results and the prognosis in children with acute lymphoblastic leukemia combined with varicella infection include the interval between the onset of first symptom and admission to hospital for treatment, and the WBC count on admission. Besides, the children with repeated infection during chemotherapy are likely to have poor treatment results and prognosis, which suggests that it is important to perform targeted behavioral intervention for the children at high risk and their parents.

Key words: Acute lymphoblastic leukemia, Varicella-herpes zoster virus, Combined infection, Analysis of prognosis, Child