知母-黄柏药对在性早熟中的临床应用研究

doi:10.20274/j.cnki.issn.1674-3865.2025.01.002

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2025, Vol. 17 ›› Issue (1): 8-12.doi: 10.20274/j.cnki.issn.1674-3865.2025.01.002

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Research on the clinical application of Zhimu-Huangbai in precocious puberty

CHEN Na¹,LI Lianke²,LU Yihong²,YANG Yang¹,TAO Qiong¹,CHEN Zhu¹

¹Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China；²Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China

Received:2024-09-01 Revised:2024-12-28 Published:2025-02-25 Online:2025-02-25
Contact: CHEN Zhu，E-mail：918236355@qq.com
Supported by:
Science and Technology Fund Project of Guizhou Provincial Health Commission(No.gzwkj2022-400)

Abstract

Abstract: Zhimu-Huangbai is a commonly used medicine pair in clinical practice,and the compatibility of the two drugs has the effects of nourishing yin and clearing heat,purging fire and detoxifying.Modern studies have found that Zhimu-Huangbai has anti-inflammatory,antioxidant,hypoglycemic,and lipidemic regulation effects because of its main active ingredients such as quercetin,kaempferol,barmatine,stigmasterol,mangiferin,berberine,etc.It is widely used in clinical practice,mainly for the treatment of precocious puberty,diabetes,diabetic nephropathy and other diseases in children.From the perspectives of chemical composition,pharmacological effects and clinical application,this paper expounds the application research of Zhimu-Huangbai in precocious puberty in recent years,in order to provide a theoretical basis for the scientific application of the drug in precocious puberty and for the research and development of new drugs.

Key words: Precocious puberty, Zhimu-Huangbai, Active ingredients, Clinical application research, Child

CHEN Na, LI Lianke, LU Yihong, YANG Yang, TAO Qiong, CHEN Zhu. Research on the clinical application of Zhimu-Huangbai in precocious puberty[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(1): 8-12.

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Research on the clinical application of Zhimu-Huangbai in precocious puberty

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