Abstract:
Objective：To investigate the effect of Changdi reagent desensitization therapy on children with allergic rhinitis and its effect on eosinophil(EOS) and eosinophil cationic protein(ECP) in children.Methods：From August 2015 to June 2016, 108 children with allergic rhinitis were admitted to the Department of Otorhinolaryngology for treatment, and they were divided into observation group and control group according to the random number table method, 54 cases in each group. The children in the observation group were given desensitization therapy, and the control group was given routine treatment. The clinical curative effect of the two groups was compared. The scores of symptoms and signs and the change of EOS and ECP after treatment was also compared.Results：The total effective rate was 96.30%(52/54) in the observation group, which was significantly higher than that in the control group(81.48%, 44/54), the difference being statistically significant(P<0.05). The scores of the symptoms and signs in the observation group were lower than those in the control group(P<0.05). The positive rate of EOS in nasal irrigation was 75.93%(41/54) in the observation group, which was significantly lower than that in the control group(92.59%, 50/54), the difference being statistically significant(P<0.05). The content of ECP in the nasal irrigation solution of the observation group was significantly lower than that of the control group(P<0.05).Conclusion：The desensitization therapy of Changdi reagent has a positive effect in improving the therapeutic effect on allergic rhinitis in children, which can significantly reduce the level of EOS and ECP in these children. It can also decrease the incidence of allergic rhinitis and reduce the impact on these children, which is worth promoting clinically.

Key words: Allergic rhinitis, Changdi reagent desensitization therapy, Eosinophils, Eosinophil cationic protein, Children