Abstract:
Objective:To study the therapeutic result of liquid resuscitation for children with septic shock.Methods:A total of 50 children with septic shock were treated in Pediatric Department of Enping People's Hospital from Jan. 2014 to Sep. 2016, and they were randomly divided into two groups: liquid resuscitation group(A) and conventional dilatation group(B), 25 children in each group. After admission, the patients were given normal saline combined with 20% albumin resuscitation treatment and conventional dilatation treatment, respectively. Compare the first-hour infusion volume of normal saline, the primary resuscitation target(first-stage resuscitation success rate), length of ICU stay, pH value, level of Na+ and Cl-, heart rate and change of central venous pressure and average arterial pressure.Results:The length of ICU stay of group A was shorter than that of group B, and the difference was statistical(P<0.01).The first-hour infusion volume of normal saline in group A was higher than that in group B, the difference being statistical(P<0.01). There was no statistical difference in the incidence rate of pulmonary edema between the two groups (P>0.05). The mortality of group A was 16.0%(4/25), lower than that of group B (48.0%,12/25), and there was statistical difference(P<0.05).The first-stage success rate of resuscitation of group A was 80.0%(20/25),higher than that of group B(52.0%,13/25),with statistical difference(P<0.05).The heart rate of children in group A after treatment was lower, and the average arterial pressure and central nervous pressure were higher than before treatment,and the difference was of statistical significance(P<0.01). The 24h pH value and Na+ concentration of children in group A were higher after treatment, while Cl- concentration was lower, the difference being statistical (P<0.01).Conclusion:Liquid resuscitation with normal saline and albumin has significant effect on children with septic shock. It is safe and worth promoting.

Key words: Septic shock, Normal saline, Albumin, Liquid resuscitation, Child