Abstract:
Objective
To investigate the relationship between the condition of children with sepsis and vascular endothelial cell dysfunction.
Methods
A total of 68 children with sepsis， who were admitted to the PICU of Guizhou People's Hospital from January 2017 to January 2018 and stayed in the Pediatric Surgery for more than 24 hours ,were selected as subjects. According to the severity of the disease, 41 patients were included in sepsis group and 27 patients in septic shock group. At the same time, 39 outpatients with healthy physical examination were selected as the control group. According to the prognosis of the children, there were 53 patients in the survival group and 15 patients in the death group. Detect the levels of inflammation indicators ［white blood cell count(WBC), C-reactive protein(CRP), interleukin-6(IL-6), procalcitonin(PCT)］ and endothelial cell injury markers［plasma endothelin 1(ET1)，von Willebrand factor(vWF) and soluble thrombomodulin(sTM)］. The correlation between inflammation markers and endothelial injury markers was analyzed.
Results
(1) The levels of CRP, IL-6, PCT, vWF, sTM and ET-1 gradually increased with the increasing severity of sepsis, and the differences between the two groups were statistically significant(P<0.05).(2) There was significant difference between the death group and the survival group(P<0.05). The WBC was significantly lower in the death group than in the survival group, and it was positively correlated with the prognosis of children with sepsis. The vWF, sTM and ET-1 were significantly higher in the death group than in the survival group, and were significantly negatively correlated with the prognosis of children with sepsis.
ConclusionThe condition and prognosis of children with sepsis are closely related to vascular endothelial injury.

Key words: Sepsis, Markers of endothelial cell injury, Correlation, Children