Abstract: Objective:To summarize spectrum of bacterial pathogens and bacteria-sensitive drugs of Baoji children with acute lower respiratory infections (ALRI).Methods:From 2010-08 to 2011-07 in three domain District of Baoji City,the children from five hospital pediatric inpatient department with acute lower respiratory tract infection made,a retrospective pooled analysis in 6 234 cases about sputum culture identification and drug susceptibility test results.Results:(1)Of 6 234 cases of censorship specimens,1 827 cases were with positive result, the positive rate being 29.31%.The 1 882 co-culture pathogens were divided into 23 kinds and the first 5 pathogens were Escherichia coli(20.72%),Klebsiella pneumoniae(17.48%),Streptococcus pneumoniae(16.84%),Pseudomonas aeruginosa(6.59%),Staphylococcus aureus(6.32%).(2)About 66.05% ALRI pathogens were G- bacteria,the vast majority of Enterobacteriaceae accounted for 86.56%,and Escherichia coli,Klebsiella pneumoniae highest in the first two accounted for 57.84%;G+cocci accounted for 29.05%;fungi ranked the seven.(3)Escherichia coli and Klebsiella pneumoniae were highly sensitive to Amoxicillin/Clavulanic acid,Ticarcillin/Clavulanic acid,Cefoxitin,Cefoperazone/Sulbactam,Piperacillin/Cilostazol Tazobactam,and could be used as an empiric antimicrobial treatment.All G- bacteria had no resistance to Imipenem.Pseudomonas aeruginosa in the region was highly sensitive to Ceftazidime.Resistance rate of streptococcus pneumoniae to penicillin was 70.57%,highly sensitive to the one to four-generation cephalosporins and amoxicillin/Clavulanic acid.Children in the region with lower respiratory tract sputum staphylococcus mainly had Staphylococcus aureus and coagulase-negative staphylococci(CNS),with oxacillin resistance rate being 92.69% and 82.69%;Streptococcus in the region leading to bacterial ALRI in children accounted for only 3.03% , highly sensitive to the antibiotics, so penicillin was still the preferred antibiotic.(4)Enterobacteriaceae as ALRI predominant pathogen in children had serious resistance,and opportunistic pathogen and opportunistic infection rates were likely to increase.Conclusions:In Baoji children ALRI bacterial pathogen spectrum has clear region and time features.Klebsiella pneumoniae,Escherichia coli,Pseudomonas aeruginosa,Streptococcus pneumoniae are 4 common pathogens in 0~14 year-old children in Baoji;pathogenic bacteria are mainly Gram-negative Enterobacteriaceae,and each age group has its own characteristics;antimicrobial susceptibility is obvious,and drug resistance problem is very grim.

Key words: lower respiratory infections, bacteria, pathogen spectrum, drug sensitivity, multi-center；children