Abstract:
Objective：To observe the clinical effect of Huaiqihuang granule in the treatment of respiratory syncytial virus(RSV) bronchiolitis in children.
Methods：Totally 70 children with RSV bronchiolitis were randomly divided into the observation group(n=35) and the control group(n=35), who received treatment from May 2014 to February 2016. The patients in the control group were treated with inhaling oxygen, relieving cough and asthma, reducing phlegm and other conventional treatment, while patients in the observation group were treated with Huaiqihuang granule on the basis of the treatment for control group for 7 days as a course of treatment. The effect and time for clinical symptoms and signs to disappear and hospitalization time were compared between the two groups, and the changes of IL-17 and IL-23 in serum were detected by ELISA method.
Results：The total effective rate of the observation group was 94.29%(33/35), which was significantly higher than 74.29%(26/35) of the control group, and the difference was statistically significant(P<0.05). The time for clinical symptoms and signs to disappear and hospital stay in the observation group were significantly shorter than those in the control group, the difference being statistically significant(P<0.05). After treatment, the expression of IL-17 and IL-23 in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).
Conclusion：Huaiqihuang granule can significantly improve the therapeutic effect on RSV bronchiolitis in children, and its mechanism may be related to the decrease of the expression of IL-17 and IL-23.

Key words: Bronchiolitis, Huaiqihuang granule, IL-17, IL-23, Respiratory syncytial virus, Child