Abstract: Objective
To study whether there is aggravation during adolescence, the proportion of aggravation and related risk factors in epileptic women.
Methods
With the method of retrospective study, a total of 101 female epilepsy patients who met the inclusion-exclusion criteria were screened and divided into aggravation group and no-aggravation group. General data, seizure information, drug use data and seizure control evaluation data were collected.
Results
In the 101 women 84 had no change in the seizure frequency, accounting for 83.17%(84/101). In 17 cases the frequency of seizures increased, accounting for 16.83%(17/101). About 69.31% of the patients had no seizures when they grew into puberty. There was statistically significant difference in EEG after treatment, seizure type and general medication between the group of aggravation and the group of no-aggravation(P＜0.05). The results of multivariate Logistic regression analysis showed that the factors affecting the seizure frequency were EEG after treatment, seizure type and general medication.
Conclusion
In most adolescent women with epilepsy，the onset of the disease becomes less frequent or they are seizure free. The patients with abnormal EEG after treatment and focal seizures are more prone to aggravate. The patients receiving traditional Chinese medicine combined with western medicine are more likely to have aggravation.

Key words: Epilepsy, Puberty, Seizure frequency, Related risk factors, Woman