Abstract: Objective
To detect the levels of BDNF and S100B protein in serum of autistic children, and to explore the relationship of BDNF and S100B with autism in children.
Methods
Totally 35 autistic children who participated in training in Luohe Disabled Rehabilitation Center from March 2016 to September 2017 were selected as the study group, including 24 children with mild autism and 11 children with severe autism. Also, 40 healthy children were selected as the control group. ELISA was used to detect the levels of BDNF and S100B protein in serum.
Results
The serum BNDF level in the study group was significantly higher than that in the control group(P<0.05). There was no significant difference in serum S100B protein level between the two groups(P>0.05). The level of serum BDNF in mild autism group was higher than that in control group(P<0.05), but there was no significant difference between severe autism group and control group(P>0.05),and there was no significant difference between mild and severe autism group, either(P>0.05).
ConclusionThe level of serum BDNF in autistic children is significantly increased, but the level of S100B protein has no significant increase. These results suggest that BDNF may be related to the occurrence and development of autism, but the relationship between S100B protein and autism is not very clear.

Key words: Autism, Serum, BDNF, S100B, Children