Abstract: Objective To observe the clinical effect of intravenous injection of immunoglobulin in the treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Methods A total of 80 RMPP children treated in our hospital from Jan. 2018 to May 2019 were randomly divided into two groups: 40 children in observation group and 40 in control group. All children in the two groups were given azithromycin sequential anti infection treatment plus corticosteroid therapy; the observation group also received intravenous injection of immunoglobulin. The recovery time of clinical symptoms and signs, the recovery time of imaging symptoms, length of hospital stay and the clinical effect after treatment were compared between the two groups. Results The recovery time of clinical symptoms and signs, the recovery time of imaging symptoms and hospitalization time in the treatment group were shorter than those in the control group with statistically significant differences(P<0.05). Meanwhile, the total effective rate of the experimental group (85.0%,34/40) was significantly higher than that of the control group(50.0%,20/40) after 2 weeks of treatment, and the difference was statistically significant(P<0.05). Conclusion The application of immunoglobulin can accelerate the recovery of clinical symptoms and signs of RMPP children, accelerate the recovery of imaging symptoms, shorten the total hospital stay, improve the overall clinical effect on children with refractory Mycoplasma pneumoniae pneumonia, and reduce the incidence of complications.

Key words: Refractory Mycoplasma pneumoniae pneumonia, Immunoglobulin, Children