Abstract: Objective:To study the changes and clinical significance of angiopoietin 2 in the serum of children with sepsis and lung injury.
Methods:A total of 90 children with sepsis treated in our hospital from July to December of 2019 were included in the study, who were divided into two groups based on the severity of disease: 63 in the sepsis group and 27 in the septic shock group. Another 30 children undergoing physical examination during the same period were chosen as the control group. Among the 90 children with sepsis, 25 had lung injury. The level of angiopoietin 2 was observed in the three groups and in the children with sepsis and lung injury.
Results:(1) The level of angiopoietin 2 in the sepsis group and septic shock group was significantly higher than that in control group (P<0.05). The level of angiopoietin 2 in sepsis group was significantly lower than that in septic shock group (P<0.05). (2) The level of angiopoietin 2 in the children with sepsis and lung injury was significantly higher than that in the septic children without lung injury (P<0.05).
Conclusion:Angiopoietin 2 has become an important biomarker in clinical determination of sepsis. It can not only indicate the disease severity but also predict the occurrence of sepsis and lung injury at an early stage, which provides support for the following clinical treatment.

Key words: Sepsis, Septic shock, Lung injury, Angiopoietin 2, Children