Abstract: Objective To explore the clinical medication rules by Youke Zabing Xinfa Yaojue in the treatment of children with infantile malnutrition. Methods Extract the medical records and prescriptions of infantile malnutrition from Youke Zabing Xinfa Yaojue，and establish the "Database of Youke Zabing Xinfa Yaojue medications for infantile malnutrition";meanwhile，the data mining methods（frequency statistics，association rules and cluster analysis） were used to analyze the clinical medication rules.Results A total of 46 prescriptions were selected，involving 124 kinds of Chinese medicines，with the frequency of application being 498.The commonly used hetbs included Licorice，Coptis chinensis，Poria cocos and Radix Picrorrhizae，etc. The herbs tonifying deficiency and antipyretic drugs accounted for the major part. The herbs with cold and warm nature accounted for a large proportion，mostly functioning through the spleen and stomach meridian. Association rules showed that there was close correlation between deficiency-nourishing drugs and deficiency-nourishing drugs，between heat-clearing drugs and anthelmintic drugs，as well as between heat-clearing drugs and digestant drugs. The core prescription was Fattening Baby Pill. It could be divided into three categories. Conclusion In the book，the treatment for infantile malnutrition should be based on the spleen and stomach，and the cold and warm drugs should be used at the same time，to attack the disease and tonify the body.

Key words:

Malnutrition, Youke Zabing Xinfa Yaojue, Medication rules；Children