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Research on the
prescription rules of prestigious Chinese physician Wang Boyue in the treatment
of pediatric diseases based on
data mining
GAO Kuijie, YANG Dongxin, DAI Huimin, LIN Jianyao, ZHANG Hengshan, LYU Ying.
2023, 15 (1):
56-60.
ObjectiveTo explore
the characteristics and rules of drugs prescribed by prestigious Chinese
physician Wang Boyue in the treatment of pediatric diseases.MethodsThe
prescriptions included in the "Wang Boyue Medical Complete
Collection" were manually retrieved, including those with complete
medication information in the medical records. After extracting the
prescription information and by referring to the Thirteenth Five-Year Plan textbook "Chinese Materia Medica" and "The
Pharmacopoeia of the People's Republic of China (2015 edition), data
standardization was performed, and the data was entered into Microsoft Excel
software after being checked by two people to establish the "Wang Boyue
Pediatric Drug Database". The frequency analysis method was used to count
the "four qi", "five flavors", "functioning
meridians" and classification of drugs. SPSS Statistic 25.0 software was
used to make systematic clustering analysis. SPSS Modeler 14.1 Apriori module
was used for association rules and complex network analysis.ResultsA total of
247 prescriptions were included, with a total of 235 drugs. The frequency of
the use of Chinese drugs was 2 519 times, and there were 33 drugs being used
more than 20 times each, accounting for 55%. The frequently used drugs were
those relieving fever and tonifying qi; the drugs were mainly cold in nature
(42.4%), and 66% functioned through lung meridian, 48% through stomach and 46%
spleen, which accounted for the most part of drugs. The drugs were mainly sweet
in flavor (60.5%). Association rules and clustering analysis results showed
that Prof. Wang Boyue was good at treating children's pulmonary diseases, and
preferred to use the classic prescriptions in the Treatise on Febrile Diseases
to treat children's diseases. His commonly used prescriptions included San'ao
tablet, Maxing Shigan decoction, Jiegeng Gancao decoction, and Yinqiao powder
with addition and subtraction. In the course of treatment, he paid special
attention to regulating the spleen and stomach; by regulating the rise and fall
of the spleen and stomach qi, regulating dampness and harmonizing stomach,
relieving dyspepsia and strengthening spleen and assisting digestion, he
comprehensively regulated the spleen and stomach in children.ConclusionProf.
Wang Boyue does a good job in using prescriptions for typhoid fever in the
treatment of pediatric diseases, pays attention to the conditioning of
children's spleen and stomach, and prefers to use "sweet" drugs, heat-clearing drugs and tonifying drugs, which mainly function through the
meridians of lung, spleen and stomach.
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