Abstract: Objective By observing the symptoms，signs，changes of serum eosinophils（EOS） and nasal secretion eosinophils（nasal EOS） before and after treatment with Qingre Tongqiao decoction，the clinical effect of Qingre Tongqiao decoction on children with allergic rhinitis(AR) will be objectively evaluated. Methods From October 2020 to August 2021, in the pediatric outpatient department of the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 60 children with allergic rhinitis were recruited, who met the TCM syndrome differentiation of lung meridian with latent heat. They were divided into observation group and control group by random single-blind control method, 30 cases in each group. The observation group was given oral Qingre Tongqiao decoction, 1 dose per day; the control group was given Xinyi Biyan pills orally, twice a day; both treatments lasted for 14 days. Observe the condition before and after treatment, and follow up for 1 month after the end of treatment.Results In the control group, 1 case was lost during the study.(1) The total effective rate of the observation group was 90.0%(27/30), which was better than that of the control group(79.3%, 23/29), and the difference was statistically significant(P<0.05).(2)The total scores of TCM syndromes in the two groups after treatment were lower than those before treatment, and the observation group was lower than the control group, the differences being statistically significant(P<0.05). (3) The blood EOS of the two groups after treatment was lower than that before treatment, and the difference was statistically significant(P<0.01).(4) The EOS level of nasal secretions in the two groups after treatment was lower than that before treatment, and the observation group was lower than the control group, the differences being statistically significant(P<0.01).(5)Follow-up: there were 20 cases(66.7%) of recurrence in the observation group,which were lower than 25 cases(86.2%) in the control group, and the difference was statistically significant(P<0.05).Conclusion Qingre Tongqiao decoction can significantly improve the symptoms of children with allergic rhinitis, reduce the level of EOS in nasal secretions, and inhibit nasal hyperresponsiveness and chronic nasal inflammation.

Key words:

Allergic rhinitis, Nasal diseases, Syndrome of lung meridian with latent heat, Eosinophil in nasal secretion, Children