Abstract: Food allergy is more common in infants under 1 year old. The intestinal symptoms caused by milk protein allergy（CMPA） are more common，mostly non-IgE -mediated. Early diagnosis is difficult，the relevant mechanism of obtaining tolerance is still unclear，and there are no specific biological indicators for diagnosis and dynamic monitoring of the disease. Therefore，it is very important to find specific biological indicators to help to make early diagnosis. Fecal calprotectin has the effect of anti-bacterial degradation and is not easy to be decomposed in the intestine. Therefore，it can truly reflect the degree of intestinal inflammation and is more intestine-specific than other inflammatory indicators. This paper reviews the application and value of fecal calprotectin in the diagnosis of non-IgE-mediated milk protein allergy in infants.

Key words:

Food allergy, Fecal calprotectin, Milk protein allergy, Non-IgE-mediated, Infants