Table of Content

25 April 2023, Volume 15 Issue 2 Previous Issue    Next Issue

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Discussion on the medication rules of Professor Qin Man in the treatment of infantile Henoch-Schnlein purpura based on data mining technology SUN Jiaxiang, DU Songhao, QIN Man. 2023, 15 (2):  93-98.  Abstract ( 86 )   PDF (1110KB) ( 7 )   Save ObjectiveTo explore the prescription application rule of Professor Qin Man in the treatment of Henoch-Schonlein purpura(HSP) in children, and to explore the potential rule of core drug combination, so as to provide evidence and reference for subsequent clinical research of HSP.MethodsThe clinical prescriptions of Henoch-Schonlein purpura treated by Professor Qin Man in the Pediatrics Clinic of Heilongjiang Academy of Traditional Chinese Medicine from June 2020 to October 2021 were collected and screened to establish a database. Data mining and visual analysis were carried out by using the methods of association rules, complex network analysis and cluster analysis, and the application frequency and combination of drugs were summarized.ResultsTotally 82 valid prescriptions were screened out in the database, involving 101 traditional Chinese medicines. The top ten prescriptions in frequency analysis were honeysuckle, licorice, Scutellaria baicalensis, Atractylodes macrocephala, Poria cocos, cicada slough,Dictamnus dasycarpus, buffalo horn, tangerine peel and field thistle. In association analysis, 37 pairs were used more than 58 times, and the top 3 pairs were honeysuckle-Scutellaria baicalensis, honeysuckle-licorice, Scutellaria baicalensis-licorice. Two prescriptions were obtained by cluster analysis: (1)Sophora flavescens, purple grass, Fructus Gardeniae Praeparatus, Schizonepeta tenuifolia, Saposhnikovia divaricata, Dictamnus dasycarpus, buffalo horn, cicada slough, tangerine peel, Pinellia ternata, Atractylodes macrocephala and Poria cocos. (2)Honeysuckle, Scutellaria baicalensis, field thistle, cogon rhizome and Agrimonia pilosa.ConclusionProfessor Qin Man combines disease differentiation with syndrome differentiation in the treatment of HSP. The main method of treatment is to clear heat, cool blood and eliminate spots, as well as to clear heat and dryness, invigorate spleen and tonify qi. Prof. Qin Man's treatment and medication rules provide ideas for the subsequent study of traditional Chinese medicine in the treatment of Henoch-Schonlein purpura. Related Articles | Metrics

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Study on the suitable temperature of traditional Chinese medicine fumigation in the treatment of children with Henoch-Schnlein purpura ZHANG Jun, HU Guili, WANG Yaru, WANG Yanwei. 2023, 15 (2):  99-104.  Abstract ( 104 )   PDF (816KB) ( 14 )   Save ObjectiveTo study the suitable temperature of Chinese medicine fumigation treatment for children with Henoch-Schonlein purpura at different ages, and to provide reference basis for standardized application of nursing operation in the treatment of child Henoch-Schonlein purpura by traditional Chinese medicine fumigation. MethodsThree-level factorial design was carried out based on two factors: children's age at 3 to 6 years old, 7 to 12 years old and 13 to 14 years old, and fumigation temperature at 39 ℃, 41 ℃ and 43 ℃.Totally 243 children with Henoch-Schonlein purpura were randomly divided into nine groups, with 27 children in each group. The clinical symptom score and comfort of each group were observed before and after treatment and safety was evaluated.Results（1）Comparison of clinical symptom scores of children of different ages after treatment at different temperatures showed: the statistical analysis results of the interaction between age and temperature, suggested that the interaction between age and temperature was not statistically significant(F=0.564,P>0.05). Further two-factor analysis of variance was performed and the results of the single effect of age showed that F=0.022, P>0.05, and the difference was not statistically significant. The results of the single effect of temperature showed that F=14.528,P<0.05, and the difference was statistically significant, that is, different temperatures had significant influence on clinical symptom score, and compared with 39 ℃, 41 ℃ and 43 ℃ had more significant influence on clinical symptom score(P<0.05);there was no statistical difference in the influence between 41 ℃ and 43 ℃ on clinical symptom score(P>0.05). （2）Comparison of subjective comfort scores of children of different ages at different temperatures: In the statistical analysis results of the interaction between age and temperature, F=50.620,P<0.05, suggesting that the interaction between age and temperature was statistically significant. The results of age alone showed that F=14.665,P<0.05, and the difference was statistically significant. The single effect of temperature showed that F=12.590,P<0.05, and the difference was statistically significant, that is, different temperatures had significant influence on children's comfort. Children aged 3 to 6 years had higher comfort at 39 ℃ and 41 ℃ than at 43 ℃, children aged 7 to 12 years had the highest comfort at 41 ℃, and children aged 13 to 14 years had the highest comfort at 43 ℃. (3)Comparison of safety grading for children of different ages at different temperatures was not statistically significant(P＞0.05) .Conclusion（1）Different temperatures of fumigation with traditional Chinese medicine have different therapeutic effects on children with Henoch-Schonlein purpura. There is no difference in the therapeutic effects on children of different ages, and age will not affect the therapeutic effects.（2）Children of different ages have different comfort for fumigation treatment with traditional Chinese medicine at different temperatures. (3) Clinically, it is recommended that 41 ℃ be used for children aged 3 to 6 years, 41 ℃ for children aged 7 to 12 years and 43 ℃ for children aged 13 to 14 years.  Related Articles | Metrics

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Effect of long-term use of caffeine citrate on the safety of very-low-birth-weight infants LU Yujiao, GAO Xirong, ZHUANG Yan, LI Junshuai. 2023, 15 (2):  105-109.  Abstract ( 74 )   PDF (795KB) ( 20 )   Save ObjectiveTo study the impact of long-term use of caffeine citrate on the safety of very-low-birth-weight infants.MethodsThe clinical data of 192 very-low-birth-weight infants treated with caffeine citrate in our hospital from December 2020 to December 2022 were discussed and analyzed.According to the total time of treatment,the infants were divided into long treatment group and routine treatment group:107 cases in the long treatment group (caffeine was used till corrected gestational age > 34 weeks) and 85 cases in conventional treatment group (caffeine was used till corrected gestational age 33 to 34 weeks).The clinical data of premature infants were compared between the two groups.ResultsThere was no significant difference in sex,age of admission,multiple pregnancy,premature rupture of membranes,cesarean section,prenatal use of glucocorticoid or prenatal use of magnesium sulfate between the long treatment group and the routine treatment group(P>0.05).The birth weight and gestational age in the long treatment group were significantly lower than those in the routine treatment group(P<0.05).The total time of caffeine application, corrected gestational age on stopping medication, corrected gestational age on oral correction and oral milk volume in the long treatment group were higher than those in the conventional treatment group,and there were significant differences between the two groups(P<0.05).There was no significant difference in the incidence of feeding intolerance or hyperglycemia(P>0.05).The incidence of broncho-pulmonary dysplasia in the long treatment group is relatively high,and the differences were statistically significant(P<0.05).ConclusionFor very-low-birth-weight infants with smaller gestational age and lower birth weight,there is no obvious adverse reaction after long-term use of caffeine until the corrected gestational age of 36 weeks,and the safety is high.For children with feeding tolerance,oral caffeine can be used at a proper time. Related Articles | Metrics

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Research progress in the application of allergen-specific immunotherapy for children with allergic diseases LI Yuemeng, KAN Xuan. 2023, 15 (2):  109-115.  Abstract ( 71 )   PDF (1223KB) ( 12 )   Save Allergen-specific immunotherapy(AIT) is a desensitization therapy for IgE-mediated allergic diseases that can not avoid allergens. At present, it is the only way to control the process of allergic diseases according to the etiology, which can achieve long-term effect. AIT can achieve therapeutic purposes by inducing the body to develop immune tolerance to specific allergens, but there are also many constraints. Although allergen-specific immunotherapy has a history of more than one hundred years, its clinical application in children's allergic diseases has yet to be deepened. This paper aims to review the mechanism, clinical application and prospect of allergen-specific immunotherapy in children's allergic diseases. Related Articles | Metrics

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Progress of research in the evaluation of airway function injury in children ZHOU Liyan, WANG Yumin. 2023, 15 (2):  116-120.  Abstract ( 66 )   PDF (800KB) ( 9 )   Save As the most common disease in children, respiratory diseases have always been the focus of diagnosis and treatment for pediatric clinicians. Current studies have confirmed that various mechanisms, such as genetic, environmental and inflammatory mediators, can affect their occurrence and development. Based on different lesion characteristics, multiple auxiliary examinations can be used as the evaluation means of airway injury assessment. In recent years, the idea of small airway disorder has led the research in respiratory diseases into a new era, so it is particularly important to apply appropriate technology to accurately locate the site of airway inflammation and damage, which can help clinicians to achieve more accurate treatment. This paper will review the current application of various examination techniques and the current status of research. Related Articles | Metrics

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Research progress on the cause and treatment of perianal abscess and anal fistula in children LIU Meifang, ZHAO Bin. 2023, 15 (2):  121-124.  Abstract ( 113 )   PDF (771KB) ( 17 )   Save Perianal abscess and anal fistula are common perianal diseases in children under 1 year of age, and currently there is no unified understanding about the pathogenesis or unified treatment plans. This paper discusses the causes of perianal abscess and anal fistula in infants based on traditional Chinese medicine and modern medicine, and explores the treatment progress from the aspects of conservative treatment and surgical treatment. Related Articles | Metrics

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Research progress on the relationship between vitamin D and heart, brain and lung development in preterm infants ZHANG Yanyan, WANG Xin, WANG Chan, ZHENG Youning 2023, 15 (2):  124-128.  Abstract ( 68 )   PDF (817KB) ( 17 )   Save Vitamin D metabolism is complicated, and the probability of vitamin D deficiency in pregnant women is still relatively high, which is becoming a hot research area. The transfer of vitamin D in the placenta occurs mainly during the third trimester of pregnancy, so premature infants are at higher risk of vitamin D deficiency. However, the heart, brain and lung functions of preterm infants are not mature. There are many previous studies on the association of vitamin D with calcium, phosphorus and metabolic bone diseases. Recent rat studies have shown that maternal vitamin D deficiency leads to changes in cardiomyocytes, nerve cells and alveolar epithelial cells. This review aims to explore the relationship between vitamin D and heart, brain and lung diseases, in order to provide new ideas for the prevention and treatment of heart, brain and lung diseases in premature infants. Related Articles | Metrics

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Research progress of Perampanel monotherapy in the treatment of epilepsy in children WU Mei, TANG Yongzai, QIAO Pei, DONG Yan. 2023, 15 (2):  129-132.  Abstract ( 68 )   PDF (806KB) ( 9 )   Save Perampanel(PER), as the first highly selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxy-5-methyl -4-isooxazolpropionic acid (AMPA) receptor antagonist approved for use, is currently approved in China for the treatment of focal epilepsy (with or without progression to bilateral tonic-clonic seizures) in adults and children aged 4 years and older. This drug was marketed late in China, and was mostly used for additive therapy in adults and children. There is little experience in the application of monotherapy for children's epilepsy. This article reviewed the mechanism of action, pharmacokinetics, efficacy and safety of PER in the treatment of childhood epilepsy at home and abroad, in order to provide reference for clinicians.  Related Articles | Metrics

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Analysis of clinical features and related risk factors in children with short stature WANG Wei, CHEN Yang, TANG Yuli, XIANG Hong. 2023, 15 (2):  133-137.  Abstract ( 109 )   PDF (779KB) ( 27 )   Save ObjectiveTo analyze the related risk factors of short stature. MethodsFrom June 2021 to October 2021, 57 short children and 123 children with normal height and development level matched by age and gender were enrolled from the Pediatric Growth and Development Clinic of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine. The medical history was collected by questionnaire, and SPSS software was used for statistical analysis of personal history, family history, general information, lifestyle and other influencing factors. ResultsSingle factor analysis showed that age, gender, birth season, time of feeding solid food, season of feeding solid food, state of mother pregnancy, gestational age at birth, mode of delivery, and being with or without birth injury had nothing to do with the occurrence of short stature; being with or without basic diseases, birth weight, feeding ways in the first 6 months, family history of short stature, exercise mode and amount, calcium supplementation and sleep habits were related to the onset of short stature. Binary logistic analysis showed that low birth weight, mixed feeding in the first 6 months, and a family history of short stature were positively correlated with the onset of short stature, while the absence of underlying diseases, adequate bouncing exercise, and sufficient night sleep were negatively correlated with the onset of stature. ConclusionThe occurrence of short stature is influenced by various hereditary and environmental factors, among which low birth weight and a family history of short stature are risk factors, while adequate amount of bouncing exercise and sufficient night sleep are protective factors for the onset of short stature. Related Articles | Metrics

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Clinical efficacy of beribizumab in a small sample of children with systemic lupus erythematosus WANG Qianhan, MIAO Yonghong, AN Lemei 2023, 15 (2):  137-141.  Abstract ( 75 )   PDF (812KB) ( 10 )   Save ObjectiveTo study the clinical effect of belimumab on children with systemic lupus erythematosus. MethodsA retrospective, real-world clinical study was conducted to analyze the clinical data of CSLE patients who were diagnosed and treated with belimumab for 16 weeks in Henan Province People's Hospital from January 2021 to August 2022. ResultsA total of 11 children (1 boy and 10 girls) were enrolled, and the average age was (13.91±1.70) years. The median course of disease on receiving belimumab was (8.91±10.41) months. After treatment, the proportion of systemic symptoms, skin and mucous membrane, and other system involvement decreased;C3 and C4 returned to normal, the anti-double-stranded DNA(dsDNA) quantitation decreased, and the urinary protein quantitation of 24 hours decreased in children with lupus nephritis. The dosage of prednisone before and after treatment was statistically different（P<0.01）.The difference in systemic lupus erythematosus disease activity index(SLEDAI-2000) and physician's global assessment(PGA) were statistically significant at different time points(0, 2, 4, 8, 12, 16 weeks) after belimumab treatment（P<0.05）.All patients achieved SRI-4 response at 16 weeks. Adverse events occurred in 2 patients(18.18%) during belimumab treatment; hemoglobin and platelet decreased in 1 case after 2 weeks of treatment; and returned to normal after 12 weeks of treatment; 1 case had upper respiratory infection.ConclusionBelimumab is effective in the treatment of CSLE with low incidence of adverse events, and the dose of glucocorticoid is reduced. Related Articles | Metrics

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Study on nalmefene hydrochloride in preventing choking cough reaction induced by sufentanil during induction of general anesthesia in children undergoing surgery YANG Qiaoyun, ZHANG Shuibing, PENG Tuochao, CHEN Zheng. 2023, 15 (2):  142-146.  Abstract ( 47 )   PDF (788KB) ( 6 )   Save ObjectiveTo study the effect of nalmefene hydrochloride in the prevention of sufentanil-induced choking cough reaction during general anesthesia induction in children undergoing surgery. MethodsToday 150 children, who underwent laparoscopic surgery for bilateral or unilateral hernia and hydrocele in our hospital from June 2021 to March 2022， were selected as the study subjects, and were randomly divided into an observation group and a control group with 75 cases each. The observation group was given 0.25 μg/kg nalmefene hydrochloride one minute before general anesthesia induction, while the control group was given the same amount of normal saline. The frequency of choking cough within one minute after injection of sufentanil, the vital signs of heart rate (HR), blood oxygen saturation (SpO2), mean arterial pressure (MAP), bispectral index (BIS) at 5, 10, 15 and 20 minutes and other adverse reactions were observed in the two groups.ResultsThe observation group had lower incidence of choking cough (0% ,0/75) and better control rate(100%,75/75) than the control group ［33.3%(25/75) and 66.7%(50/75)］ ,and the difference had statistical significance (P<0.05). However, no obvious difference was found in SBP, DBP, MAP, HR, SpO2 or BIS between the two groups at 5min, 10min and 20min(P>0.05). At 15min, SBP and BIS in the observation group were lower than those in the control group(P<0.05). No significant difference was found in DBP, MAP, HR or SpO2 between the two groups(P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups［4.0%(3/75) in control group vs 1.3%(1/75) in observation group］. ConclusionThe administration of 0.25 μg/kg nalmefene hydrochloride one minute before anesthesia induction after entering the operation room can effectively prevent the sufentanil-induced choking cough reaction during general anesthesia in children, which does not affect the hemodynamics or increase the adverse drug reactions, so it can be safely used in clinic. Related Articles | Metrics

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Misdiagnosis of adrenal neuroblastoma in children: experience summary of 2 cases WANG Shuangyi, CUI Zhengjiu, DIAO Juanjuan. 2023, 15 (2):  146-148.  Abstract ( 66 )   PDF (754KB) ( 9 )   Save drenal neuroblastoma is a malignant tumor with high incidence in children, and because of its insidious onset and diverse and non-specific clinical symptoms, it is mostly stage four when identified. Early clinical detection is difficult and diagnosis is often delayed. Through the analysis and summary of two cases of adrenal neuroblastoma misdiagnosed recently in Shandong Provincial Hospital of Traditional Chinese Medicine, the reasons for the misdiagnosis of this disease were systematically reviewed from the grassroots level and disease characteristics, which will provide a reference for pediatricians to clinically diagnose and identify adrenal neuroblastoma in order to reduce misdiagnosis and mistreatment. Related Articles | Metrics

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Effects of transfusion safety management under feedforward control concept on transfusion extravasation risk and stress hormone levels in neonates  JI Ziman, HOU Zhen, WANG Qian. 2023, 15 (2):  149-152.  Abstract ( 52 )   PDF (765KB) ( 7 )   Save ObjectiveTo investigate the effects of transfusion safety management under the feedforward control concept on transfusion extravasation risk and stress hormone levels in neonates. MethodsA total of 105 neonates requiring intravenous infusion from January 2021 to September 2022 in our department were selected as research subjects and randomly divided into control group(52 cases) and observation group(53 cases). The control group was given routine intravenous infusion nursing, and the observation group was given infusion nursing based on feedforward control. The scores of infusion, stress and infusion response were compared between the two groups.ResultsThe success rate of one puncture in observation group was 92.45%(49/53), higher than that in control group(69.23%，36/52), and the total complication rate was 1.89%(1/53), lower than that in control group(19.23%,10/52), the difference being statistically significant (P<0.05). The heart rate, mean arterial pressure, epinephrine and norepinephrine levels of the two groups were higher after infusion than before infusion, and the control group was higher than the observation group, the difference being statistically significant(P<0.05). The scores of facial expression, crying, reflexive avoidance, struggling and restlessness in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05).ConclusionInfusion safety management under the feedforward control concept can improve the infusion situation of newborn infants, reduce the risk of complications such as infusion extravasation, alleviate the stress reaction during infusion, and alleviate the infusion reaction of newborn infants. Related Articles | Metrics

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Effect of neuromuscular electrical stimulation combined with occupational therapy on upper limb function recovery and nerve conduction velocity in children with brachial plexus injury LU Jing, ZHANG Yufei, WEI Xiang. 2023, 15 (2):  153-156.  Abstract ( 68 )   PDF (767KB) ( 23 )   Save ObjectiveTo explore the effect of neuromuscular electrical stimulation combined with occupational therapy in children with brachial plexus injury and its influence on nerve conduction velocity and upper limb function recovery. MethodsA total of 80 children with brachial plexus injury admitted to Henan Provincial People's Hospital from January 2019 to June 2022 were randomly divided into the observation group and the control group with 40 cases in each group. The control group was given occupational therapy, and the observation group was given occupational therapy combined neuromuscular electrical stimulation therapy. The upper limb function, shoulder range of motion and nerve conduction velocity were compared between the two groups. ResultsAfter intervention, the Mallet, Gilbert and Raimondi scores, anterior flexion and upward lift, abduction and upward lift, posterior extension, external rotation, internal rotation, adductor activity, and the conduction velocity of ulnar nerve, median nerve and radial nerve in the observation group were higher than those in the control group, the difference being with statistical significance(P<0.05).ConclusionNeuromuscular electrical stimulation combined with occupational therapy can effectively improve nerve conduction velocity and range of shoulder motion in children with brachial plexus injury, and promote the recovery of upper limb function. Related Articles | Metrics

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Effect of auxiliary communication system training on children with auxiliary cerebral palsy and communication disorder ZHANG Yage, WANG Xiaozhe, WANG Xiaopin. 2023, 15 (2):  157-161.  Abstract ( 48 )   PDF (782KB) ( 8 )   Save ObjectiveTo explore the effects of auxiliary communication system (AAC) and language/speech training on children with spastic cerebral palsy (cerebral palsy) with communication disorders.MethodsA total of 97 children with spastic cerebral palsy and communication disorder admitted to our department from August 2020 to June 2022 were selected and randomly divided into control group (48 cases) and observation group (49 cases). The control group was given language/speech training, and the observation group was given combined AAC intervention. The behavioral problems, communication ability and development level of the two groups were compared. ResultsAfter intervention, the scores of Conners behavior scale in the observation group were lower than those in the control group, and the scores of developmental quotient and social response scale in Gesell developmental diagnostic scale were higher than those in the control group, the differences being with statistical significance (P<0.05). ConclusionAAC assisting language/speech training can effectively improve development level, reduce behavior problems and improve communication ability in children with spastic cerebral palsy. Related Articles | Metrics

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Investigation into the causes of frequently-occurring attention deficit hyperactivity disorder in children with primary immunodeficiency and discussion on the causes based on traditional Chinese and western medicine GUO Sitong. 2023, 15 (2):  161-164.  Abstract ( 88 )   PDF (774KB) ( 5 )   Save ObjectiveTo explore the incidence and causes of attention deficit hyperactivity disorder (ADHD) in children with primary immunodeficiency disease (PID).MethodsFrom November,2021 to April,2022,a questionnaire(SNAP-Ⅳ,parents edition) on attention deficit hyperactivity disorder (ADHD) was sent to the group of patients spontaneously created by PID patients (all diagnosed by specialists).The questionnaire was filled out spontaneously by family members of children aged 6 to18 years,and each symptom was evaluated by Likert4-point method (0:none,1:a little,2:quite a little,3:much), and the average of the total scores were graded: mild(1 to 1.5),moderate(＞1.5 to 2), and severe(>2).ResultsAmong 68 children with PID,15 children had attention deficit hyperactivity disorder (ADHD),and the incidence rate was 22.05%,including 12 boys and 3 girls.Among 62 immunodeficiency children with X- linked agammaglobulinemia(XLA),12 children had ADHD,and the incidence rate was 19.35%,including 11 boys and 1 girl.ConclusionThe incidence of ADHD in children with PID is high,so it is necessary to intervene in many aspects to prevent and treat ADHD in children with PID,such as reducing the incidence of upper respiratory tract infection and increasing positive psychological education for parents. Related Articles | Metrics

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Status of childhood unintentional injuries during the local COVID-19 pandemic and the influencing factors XIN Meiyun, LI Yihua, WANG Xiaoshuang, BAI Yingge. 2023, 15 (2):  165-169.  Abstract ( 71 )   PDF (782KB) ( 13 )   Save ObjectiveTo analyze the situation of the incidence of childhood unintentional injuries during the local novel coronavirus pneumonia (coronavirus disease 2019,COVID-19) pandemic in Jining and the influencing factors,and to provide a reference for prevention strategies during the COVID-19 pandemic. MethodsThe caregivers of children attending the pediatric outpatient clinic of the Affiliated Hospital of Jining Medical College from September 1,2022 to October 31,2022 were selected, who were given questionnaires to investigate the unintentional injuries of children under their care in the past 2 months. They were divided into observation group (accidental injury occurred) and control group (no accidental injury occurred). ResultsTotally 592 questionnaires were sent out, 584 returned. About 30.82%（180/584） of the caregivers reported that their children had different degrees of accidental injuries,with falls and bumps being the most common type of injury,accounting for 69.44%（125/180） in the accidental injury group,followed by bed falls［37.78%（68/180）］ and burns［21.11%（38/180）］.The differences in the relationship between caregivers and children (P=0.002), children's age (P<0.001), registered permanent residence (P< 0.001), education level of caregivers (P=0.007), number of children cared for (P=0.009), age of caregivers (P< 0.001), caregiver occupation (P<0.001), caregiver income status (P<0.001) were statistically significant in the observation group compared with the control group. In the univariate analysis, caregivers aged 31 to 50 years, caregivers being mothers, caregivers living in cities, caregivers being professional and technical personnel were positively correlated with children's unintentional injuries. Multiple regression analysis showed that after adjusting for confounders, caregivers' age between 30 to 40 years (OR=3.460, 95%CI 1.53-7.82, P=0.01) and children's age between 4 to 6 years(OR=6.342, 95%CI 1.67-24.08, P<0.01) were independent risk factors for the occurrence of childhood unintentional injuries. About 46.23%（270/584） of caregivers reported that they did not know about CPR, 40.23%（235/584） reported that they did not know about the Heimlich maneuver, 34.42%（201/584） did not receive health education related to accidental injury prevention, and 38.36%（224/584） did not actively learn first aid skills. ConclusionSince the local COVID-19 outbreak in Jining City at the end of August 2022, unintentional injuries in children are relatively common, and caregivers are generally in lack of first aid knowledge and ability; caregivers between the age of 31 and 40 should receive more training on their knowledge and skills in unintentional injuries, and focus needs to be placed on the preschool age group. Related Articles | Metrics

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Review on the treatment for pertussis with traditional Chinese medicine XIA Qi, WANG Xin 2023, 15 (2):  170-173.  Abstract ( 98 )   PDF (763KB) ( 28 )   Save Western medicine treatment for pertussis is mainly by antibiotic treatment and symptomatic treatment. Due to antibiotic resistance, the curative effect is not good. The common treatment methods for pertussis by traditional Chinese medicine include eliminating lung qi, harmonizing the stomach and stopping vomiting, soothing the liver and purging fire, clearing the lung and stopping cough, activating blood circulation and resolving blood stasis, clearing heat and resolving phlegm, relieving the external heat and dispersing coldness, and warming the lung and resolving yin. In addition to oral administration of traditional Chinese medicine decoction, external treatment methods such as acupuncture, acupoint application, massage and cupping can also be used to treat pertussis. The above methods have achieved good results. Because the incidence of pertussis has increased in recent years, the author summarized the traditional Chinese medicine treatment for pertussis through reading the literature in order to expand the ideas for further seeking effective methods of treating pertussis. Related Articles | Metrics

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Clinical observation on the treatment for child lobar pneumonia with Chinese medicine foot bathing combined with Hufu Tongbian scraping WEI Mingjie, PENG Minghao, HAN Hui, YAO Haiping, ZHANG Yuanyuan, LIU Shu. 2023, 15 (2):  173-177.  Abstract ( 67 )   PDF (763KB) ( 7 )   Save ObjectiveTo observe the clinical effect of Chinese medicine foot bathing combined with Hufu Tongbian scraping on child lobar pneumonia (heat toxin obstructing lung). MethodsA total of 60 child with lobar pneumonia (heat toxin obstructing lung) were selected and randomly divided into an observation group and a control group, with 30 cases in each group. The control group was given western medicine as intervention treatment, and the observation group was given traditional Chinese medicine foot bathing plus Hufu Tongbian scraping therapy on the basis of the treatment for the control group. The course of treatment in both groups was 7 days. Clinical efficacy, TCM syndrome score, plasma prothrombin time(PT), activated partial thrombin activity(APTT) and D-dimer(D-D) were observed and compared between the two groups. ResultsThe total effective rate of observation group was higher than that of control group(P<0.05). After treatment, the scores of fever, cough, phlegm, lung auscultation, mental state, diet and stool in the observation group were lower than those in the control group(P<0.05), and the score of wheezing was lower than that in the control group(P>0.05). After treatment, PT and APTT levels in the observation group were higher than those in the control group, while D-D levels were lower than those in the control group(P<0.05). ConclusionChinese medicine foot bathing combined with Hufu Tongbian therapy is safe and effective in the adjuvant treatment of children with lobar pneumonia. It plays an important role in improving the clinical symptoms and signs and coagulation function of children, which is worthy of clinical application. Related Articles | Metrics

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Pediatric perspiration syndrome is treated from kidney  ZHANG Xueyi, YANG Qingxiang, CHANG Ke. 2023, 15 (2):  178-181.  Abstract ( 85 )   PDF (764KB) ( 23 )   Save Pediatric perspiration syndrome often has deficiency syndrome and excess syndrome at the same time, and there is co-existence of self-sweating and night sweating. Kidney mainly regulates water and stores essence, which is the physiological basis for the regulation of sweating metabolism through kidney. Children are insufficient in the development of qi and renal function, so it is better to have supplementation at a young age. Treatment based on kidney is the root for treatment of perspiration syndrome with insufficiency. The children who are deficient in kidney-yin should be given nourishment of kidney-yin to purge fire and eliminate heat. The children who are deficient in kidney-yang should receive mild supplementation of kidney-yang to absorb qi and stop sweating. The treatment for various kinds of perspiration syndrome should take kidney-qi into account on the basis of differential treatment, warming kidney and absorbing fluid. Related Articles | Metrics

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Analysis of medication rules of traditional Chinese medicine for children with recurrent respiratory tract infection based on data mining CAO Xue, DUAN Xiaozheng, BAO Zhixin, SUN Linlin, CHENG Yu, ZENG Jingyun. 2023, 15 (2):  181-185.  Abstract ( 85 )   PDF (998KB) ( 11 )   Save ObjectiveTo count the use of Chinese medicine in the treatment of children with recurrent respiratory tract infection in children and to explore the medication rules.MethodsUsing Excel software, the literatures on TCM compound treatment for children with recurrent respiratory tract infection were collected from CNKI,Wanfang Database,Vipnet and PubMed from the inception to Apr. 2022.The data mining analysis was carried out with the help of association rules and clustering analysis methods integrated by IBM SPSS Modeler and IBM SPSS Statistics. ResultsA total of 113 prescriptions were included, involving 144 kinds of TCM. The single medicine with the highest frequency was Atractylodes macrocephala. The medicines were mostly cold and sweet in nature, and functioned through lung meridian. The two and three associations with high confidence were astragalus-atractylodes and astragalus-atractylodes-windproof. Based on cluster analysis, when the high-frequency TCM was clustered into three categories, five TCM prescriptions could be obtained.ConclusionAt present, traditional Chinese medicine is used as basic treatment for children with recurrent respiratory tract infection by invigorating qi, tonifying the spleen, nourishing the lungs and relieving the external symptoms supplemented by regulating qi and digesting food and other foods. In this study, five prescriptions were obtained, including Ginseng-schisandra decoction, Guizhi decoction, Baohe pill, Yupingfeng powder and Shenling Baizhu powder. Related Articles | Metrics