Abstract: Objective To study the suitable temperature of Chinese medicine fumigation treatment for children with Henoch-Schnlein purpura at different ages, and to provide reference basis for standardized application of nursing operation in the treatment of child Henoch-Schnlein purpura by traditional Chinese medicine fumigation. Methods Three-level factorial design was carried out based on two factors: children's age at 3 to 6 years old, 7 to 12 years old and 13 to 14 years old, and fumigation temperature at 39 ℃, 41 ℃ and 43 ℃.Totally 243 children with Henoch-Schnlein purpura were randomly divided into nine groups, with 27 children in each group. The clinical symptom score and comfort of each group were observed before and after treatment and safety was evaluated.Results（1）Comparison of clinical symptom scores of children of different ages after treatment at different temperatures showed: the statistical analysis results of the interaction between age and temperature, suggested that the interaction between age and temperature was not statistically significant(F=0.564,P>0.05). Further two-factor analysis of variance was performed and the results of the single effect of age showed that F=0.022, P>0.05, and the difference was not statistically significant. The results of the single effect of temperature showed that F=14.528,P<0.05, and the difference was statistically significant, that is, different temperatures had significant influence on clinical symptom score, and compared with 39 ℃, 41 ℃ and 43 ℃ had more significant influence on clinical symptom score(P<0.05);there was no statistical difference in the influence between 41 ℃ and 43 ℃ on clinical symptom score(P>0.05). （2）Comparison of subjective comfort scores of children of different ages at different temperatures: In the statistical analysis results of the interaction between age and temperature, F=50.620,P<0.05, suggesting that the interaction between age and temperature was statistically significant. The results of age alone showed that F=14.665,P<0.05, and the difference was statistically significant. The single effect of temperature showed that F=12.590,P<0.05, and the difference was statistically significant, that is, different temperatures had significant influence on children's comfort. Children aged 3 to 6 years had higher comfort at 39 ℃ and 41 ℃ than at 43 ℃, children aged 7 to 12 years had the highest comfort at 41 ℃, and children aged 13 to 14 years had the highest comfort at 43 ℃. (3)Comparison of safety grading for children of different ages at different temperatures was not statistically significant(P＞0.05) .Conclusion （1）Different temperatures of fumigation with traditional Chinese medicine have different therapeutic effects on children with Henoch-Schnlein purpura. There is no difference in the therapeutic effects on children of different ages, and age will not affect the therapeutic effects.（2）Children of different ages have different comfort for fumigation treatment with traditional Chinese medicine at different temperatures. (3) Clinically, it is recommended that 41 ℃ be used for children aged 3 to 6 years, 41 ℃ for children aged 7 to 12 years and 43 ℃ for children aged 13 to 14 years. 

Key words: Henoch-Sch nlein purpura, Age, Temperature, Fumigation with traditional Chinese medicine