Abstract: Objective To explore the incidence and causes of attention deficit hyperactivity disorder (ADHD) in children with primary immunodeficiency disease (PID).Methods From November,2021 to April,2022,a questionnaire(SNAP-Ⅳ,parents edition) on attention deficit hyperactivity disorder (ADHD) was sent to the group of patients spontaneously created by PID patients (all diagnosed by specialists).The questionnaire was filled out spontaneously by family members of children aged 6 to18 years,and each symptom was evaluated by Likert4-point method (0:none,1:a little,2:quite a little,3:much), and the average of the total scores were graded: mild(1 to 1.5),moderate(＞1.5 to 2), and severe(>2).Results Among 68 children with PID,15 children had attention deficit hyperactivity disorder (ADHD),and the incidence rate was 22.05%,including 12 boys and 3 girls.Among 62 immunodeficiency children with X- linked agammaglobulinemia(XLA),12 children had ADHD,and the incidence rate was 19.35%,including 11 boys and 1 girl.Conclusion The incidence of ADHD in children with PID is high,so it is necessary to intervene in many aspects to prevent and treat ADHD in children with PID,such as reducing the incidence of upper respiratory tract infection and increasing positive psychological education for parents.

Key words:

Primary immunodeficiency disease, Attention deficit hyperactivity disorder, Etiology based on traditional Chinese and western medicine