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25 December 2022, Volume 14 Issue 6 Previous Issue    Next Issue

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Expert Consensus on the Prevention and Treatment of Children's Recurrent Respiratory Tract Infection by Integrating Traditional Chinese and Western MedicineRespiratory Group of Pediatric Committee of Chinese Association of Integrative Medicine Yunxiao Shang , Xuefeng Wang 2022, 14 (6):  461-467.  Abstract ( 311 )   PDF (1482KB) ( 211 )   Save Recurrent respiratory tract infection is a common clinical phenomenon in children，which has a high incidence and brings a heavy burden to society and medical care，and has attracted much attention from pediatricians. The expert consensuses at home and abroad provided important guidance and suggestions for the diagnosis and treatment of children′s recurrent respiratory infections，but they were limited to the field of western medicine and did not include valuable experience in traditional Chinese medicine. The Expert Consensus on the Prevention and Treatment of Children′s Recurrent Respiratory Tract Infection by Integrating Traditional Chinese and Western Medicine integrates the traditional Chinese treatment based on syndrome differentiation with western medicine，revised repeatedly with reference to the latest guidelines，consensus and research progress of Chinese and Western medicine worldwide. This consensus will provide an important basis for pediatricians to reasonably integrate traditional Chinese and western medicine in the prevention and treatment of children′s recurrent respiratory infections. Related Articles | Metrics

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Research progress of vestibular rehabilitation training for children with cerebral palsyYU Chaonan YU Nan, LI Dongxiao, WAN Kai, SHANG Qing 2022, 14 (6):  468-472.  Abstract ( 96 )   PDF (832KB) ( 573 )   Save Cerebral palsy is a group of syndromes characterized by movement disorders，abnormal posture，musclestrength and muscle tension changes. The main function of the vestibular system is to maintain the stability of the head and trunk，maintain body balance and motor coordination. The vestibular function damage of children with cerebral palsy can lead to impaired balance function，poor posture control，difficulty in eye movement，poor head-eye coordination and delayed motor development. Vestibular rehabilitation training is an individualized non-drug rehabilitation treatment， which,mainly through vestibular adaptation，vestibular acclimatization，vestibular compensation and other mechanisms and through repeated strengthening of vestibular receptors，improves the excitability of nerve cells and promotes the injury of brain tissue area to produce new neural pathways，so as to effectively improve the patient′s motor function，posture control，balance ability，muscle strength and muscle tension，eye movement and so on. At present，vestibular rehabilitation training has been widely used in adults with Parkinson′s disease，stroke，spinal cord injury，Alzheimer′s disease. It has also been used in children with autism spectrum disorder，attention deficit hyperactivity disorder，and global developmental delay. There are few reports on the effects of vestibular rehabilitation training on children with cerebral palsy. Based on the above background，this paper summarizes the vestibular rehabilitation training mechanism of vestibular rehabilitation training in the treatment of children with cerebral palsy at home and abroad，in order to provide help for better improving the quality of life of children with cerebral palsy. Related Articles | Metrics

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Influence of specific acupoint massage focusing on "invigorating the spleen and strengthening the kidney" on cerebral blood flow in children with cerebral palsy TAN Longze, LIU Chunlei, WANG Paoqiu, LUO Wei, HUANG Chao 2022, 14 (6):  473-476.  Abstract ( 82 )   PDF (816KB) ( 8 )   Save ObjectiveTo explore the effect of massage at specific acupoints under the principle of "invigorating the spleen and strengthening the kidney" on the motor function，comprehensive rehabilitation effect and cerebral blood flow in children with cerebral palsy.MethodsSelect 102 children with cerebral palsy treated in our department from July 2020 to February 2022 as the research subjects，and divide them into two groups(51 in each) by random number table method. The control group was given routine massage，and the observation group was additionally given massage at specific acupoints in pediatric massage therapy under the principle of "invigorating the spleen and strengthening the kidney". The clinical comprehensive rehabilitation effect，gross motor function, fine motor function and cerebral blood flow velocity of the two groups were compared.ResultsAfter intervention，the total effective rate of the observation group was 94.12%, higher than that of the control group，which was 80.39%（P＜0.05）；the gross motor function and fine motor function scores of the observation group were higher than those of the control group，and the differences were statistically significant（P＜0.05）；the blood flow velocities of the anterior cerebral artery（ACA），middle cerebral artery（MCA），and posterior cerebral artery（PCA）in the two groups were all higher than those before the intervention，and the observation group was higher than the control group，and the vascular pulsatility index was lower than before intervention,and it was lower in the observation group than the control group(P<0.05).ConclusionOn the basis of traditional massage techniques，strengthening the specific acupoint massage mainly focusing on "invigorating the spleen and strengthening the kidney" has the advantages of improving the level of cerebral blood perfusion，which can effectively improve the level of motor development，and help children with cerebral palsy to recover comprehensively with good effect. Related Articles | Metrics

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Application of core stability training in rehabilitation of children with spastic cerebral palsy and its effect on serum BDNF and IGF-1 levels ZHAO Weiwei 2022, 14 (6):  477-480.  Abstract ( 58 )   PDF (785KB) ( 115 )   Save ObjectiveTo investigate the effects of core stability training on gross motor function,surface EMG of adductor muscle and gastrocnemius muscle,and serum brain-derived neurotrophic factor(BDNF) and insulin-like growth factor(IGF-1) in children with spastic cerebral palsy(CP for short).MethodsA total of 95 children with spastic cerebral palsy admitted to our hospital from October 2020 to February 2022 were selected as research subjects: 47 cases in the control group were given routine rehabilitation,and 48 cases in the observation group were additionally given core stability training.The scores of each area of the Gross Motor Function Test Scale 88(GMFM-88) were compared between the two groups.The surface electromyography(RMS) of adductor muscle and gastrocnemius muscle,and the level of nerve related factors(BDNF,IGF-1) were also compared.ResultsAfter intervention,the GMFM-88 D zone score and E zone score in the observation group were higher than those in the control group,the levels of adductor muscle RMS and gastrocnemius muscle RMS were lower than those in the control group,and the levels of BDNF and IGF-1 were higher than those in the control group,with statistical difference(P<0.05).ConclusionCore stability training has definite effect on children with spastic cerebral palsy,which can effectively improve the level of nerve-related factors,reduce muscle tension and improve gross motor function in children,and has clinical promotion value. Related Articles | Metrics

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A study on the mechanism of short-chain fatty acids produced by the intestinal flora affecting the core symptoms of autism spectrum disorder WU Jianye, XU Lei, KANG Beibei, JIANG Zhimei, XU Ruiyang, CHEN Ning 2022, 14 (6):  481-485.  Abstract ( 84 )   PDF (856KB) ( 135 )   Save The digestive system is one of the nine major systems of the human body and is an important system for the body to obtain and absorb nutrients. The gastrointestinal tract is the part where food is decomposed and absorbed, and the intestinal flora is distributed in different parts of the gastrointestinal tract, participating in the composition of the gastrointestinal system, which is conducive to the homeostasis of the intestine, while synthesizing some substances needed by the human body, playing a role in the digestion and absorption of food. The various substances synthesized by the intestinal flora play a role in the maintenance of the intestinal barrier, the suppression of intestinal inflammation, the human immune system, and neurodevelopment. In recent years, the incidence of autism spectrum disorders has shown an increasing trend year by year, and the comorbid diseases that accompany children with autism have also attracted the attention of scholars. Gastrointestinal disease is one of the common comorbid diseases in children with autism spectrum disorder, and many ASD children had diarrhea, constipation and other gastrointestinal diseases.However， the specific mechanism by which gastrointestinal disorders occur in ASD children is unclear. Studies have found that changes in the level of short-chain fatty acids produced by the intestinal flora in the intestine can affect the core symptom performance of ASD children.This finding has attracted the attention of scholars, and provides a new idea for the mechanism research and prevention of comorbid gastrointestinal diseases in ASD children. This article reviews the mechanisms by which short-chain fatty acids produced by intestinal flora affect the core symptoms of autism spectrum disorder. Related Articles | Metrics

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Analysis of viral pathogen spectrum in hospitalized children with respiratory tract infection in Baiyin area in recent 2 years ZHANG Lanyu, ZHUANG Wei, WANG Jiaomei 2022, 14 (6):  486-490.  Abstract ( 61 )   PDF (869KB) ( 22 )   Save ObjectiveTo analyze the epidemic law of main respiratory virus infection in hospitalized children with respiratory tract infection in Baiyin area.MethodsTotally 1 854 cases of children with respiratory tract infection were studied.IgM Antibody of respiratory virus was detected by indirect immunofluorescence.ResultsRespiratory virus was detected in 352 cases（19.0%）.PIV was detected in 164 cases，accounting for 46.6%;the number of PIV was the most in every month，PIV was the main virus of respiratory tract infection and PIV was the highest in August;IFVB was the second.IFVA was not detected.All kinds of virus were the lowest in November.The highest virus detection rate was in the 4 to 5 year old group(102 cases,23.5%)，the lowest in the ≤1 year old group(46 cases,11.4%).The PIV and RSV were dominant in the ≤1 year old group，and PIV was dominant in the other age groups.The virus detection rate in female was significantly higher than that in male（P<0.05）.The detection rate of virus in children with bronchial infection was the highest（24.9%），and that of PIV was the highest in all kinds of diseases.ConclusionPIV is the main viral pathogen in children with respiratory tract infection in Baiyin area，followed by IFVB.PIV infection is the highest in August.The infection rate of various viruses is the lowest in August and November，and the highest in children aged 4 to 5 years.The infection rate of virus in female was higher than that in male，the infection rate of virus in bronchial infections is the highest，and the proportion of virus in the same area changes with time. Related Articles | Metrics

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Risk factors and pathogenic bacteria of intrauterine infectious pneumonia in premature infants in ethnic minority areas CUI Peicong, HE Liqian, MENG Xiantao, AN Zhiguo, BU Shanshan, MA Weizhong 2022, 14 (6):  491-495.  Abstract ( 76 )   PDF (820KB) ( 47 )   Save ObjectiveTo investigate and analyze the risk factors of intrauterine infectious pneumonia in preterm infants, and to explore its etiological distribution.MethodsFrom January 2019 to August 2021, 60 premature infants with intrauterine infectious pneumonia and 60 healthy premature infants in our hospital were selected as research objects, which were set as observation group and control group.The data of preterm infants and their mothers in the observation group and the control group were compared, the risk factors of infectious pneumonia during intrauterine period in preterm infants were analyzed. The throat swab samples of premature infants with intrauterine infectious pneumonia were collected for bacterial culture, and the distribution of pathogenic bacteria of premature infants with intrauterine infectious pneumonia was counted.ResultsUnivariate analysis showed that between the observation group and the control group， there was statistical difference in amniotic fluid pollution,fetal distress, chorioamnionitis, maternal C reactive protein, late pregnancy fever, gestational hypertension and gestational diabetes mellitus (P<0.05); there were no statistically significant differences in maternal age, previous fertility, gestational age or fetal gender between the two groups(P>0.05). Multivariate Logistics regression analysis showed that amniotic fluid pollution, intrauterine distress, chorioamnionitis, maternal C-reactive protein ≥8.0 mg/L, fever in the third trimester, hypertension during pregnancy and gestational diabetes mellitus were the risk factors leading to intrauterine infectious pneumonia in premature infants(P<0.05). Among 60 cases of premature infants with intrauterine infectious pneumonia, 85 strains were isolated by pathogen culture, including 59 strains of gram-negative bacteria, 20 strains of gram-positive bacteria and 6 strains of fungi.ConclusionThe occurrence of intrauterine infectious pneumonia in premature infants is mainly related to amniotic fluid pollution, intrauterine distress, chorioamnionitis, maternal C-reactive protein, fever in the third trimester, hypertension during pregnancy,and gestational diabetes mellitus. Targeted preventive measures should be taken according to the risk factors, and prevention and treatment strategies should be formulated according to the distribution types of pathogenic bacteria of intrauterine infectious pneumonia in premature infants. Related Articles | Metrics

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Leukoencephalopathy with vanishing white matter: two cases of monozygotic twins and literature  review SU Huihong, LIN Caimei, ZHENG Xiaolan, WU Lingling 2022, 14 (6):  495-498.  Abstract ( 66 )   PDF (1532KB) ( 84 )   Save The clinical data and gene detection results of 2 children with leukoencephalopathy with vanishing white matter(VWM) in monozygotic twins were analyzed retrospectively. The children,female,were 4-year-and-10-month-old monozygotic twins. The elder of the twins was hospitalized for "abnormal gait for 2 months"; the younger of twins was hospitalized for "abnormal gait for 1 month". It was G3P3,and they were delivered at 37+4 weeks of gestation by cesarean section. The birth weight was 3 350 g and 3 250 g respectively. There was no history of asphyxia rescue at birth. They had normal development until after onset,both patients had abnormal gait,unstable walking,bilateral tendon hyperreflexia,and bilateral ankle clonus. Head plain scanning+enhancement+spectralanalysis+diffusion tensor imaging showed diffuse bilateral symmetric abnormal signals. The gene result showed a compound heterozygous mutation (not reported in China): EIF2B4 c.1544T>A (p.leu515gln),c.1445G>T (p.arg482leu). Their parents were both heterozygotes. VWM is one of the hereditary leukoencephalopathies,which is extremely rare. The diagnosis should be based on clinical manifestations,imaging and EIF2B gene analysis. Related Articles | Metrics

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Distribution of pathogenic bacteria in septic children and the significance of sCD14-ST in early diagnosis XIAO Ting, HUANG Xiaohua, CHEN Liping, WU Dingchang 2022, 14 (6):  499-503.  Abstract ( 97 )   PDF (833KB) ( 59 )   Save ObjectiveTo investigate the distribution of positive pathogenic bacteria in blood culture of neonates with sepsis and the value of sCD14-ST in early diagnosis.MethodsDetect the blood culture pathogens of septic children in the neonatal ward of the first hospital of Longyan City，Fujian Province from January 2019 to December 2019，and analyze the levels of sCD14-ST，WBC，N% and serum CRP.ResultsThe basic diseases of neonatal sepsis mainly included neonatal respiratory distress syndrome，accounting for 36.5%（19/52）.The pathogenic bacteria of term infants were mainly Escherichia coli and Staphylococcus aureus.Escherichia coli was the main pathogenic bacteria in premature infants. There was significant difference in sCD14-ST and serum CRP among the three groups（P＜0.05），but there was no significant difference in WBC，N% or PCT（P＞0.05）.There was significant difference in sCD14-ST between Gram-positive bacteria group and Gram-negative bacteria group（P＜0.01）.The areas under the curve for sCD14-ST and CRP were （ROCAUC=0.89,0.70），respectively. The diagnostic sensitivity and specificity of sCD14-ST were 88.5% and 86.7%.ConclusionEscherichia coli is the main pathogenic bacteria in neonatal sepsis.sCD14-ST has guiding value in early diagnosis. Related Articles | Metrics

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Expression and significance of Toll-like receptor in children with rotavirus enteritis and myocardial damage GU Xiaoling, CHEN Yin, LI Xiaolin, PENG Wenjuan, LIU Jingtao. 2022, 14 (6):  503-507.  Abstract ( 52 )   PDF (1235KB) ( 62 )   Save ObjectiveTo detect the expression and significance of Toll-like receptor 2/4（TLR2/4） in peripheral blood monocytes of children with rotavirus（RV） enteritis complicated with myocardial damage.MethodsTotally 25 cases of RV enteritis with myocardial damage and 25 cases of RV without myocardial damage were selected as the research subjects，another 25 healthy children were selected as the control group. Serum CK，CK-MB，LDH，AST，TNF-α，IL-8，CRP and INF-γ were detected by enzyme-linked immunosorbent assay（ELISA），TLR2/4 gene expression in peripheral blood monocytes of patients in each group was detected by real-time fluorescence quantitative PCR（RT-qPCR），the expression of TLR2/4 protein in peripheral blood monocytes was detected by flow cytometry.ResultsThe serum CK，CK-MB，LDH，AST，TNF-α，IL-8，CRP，INF-γ and the gene and protein expression of TLR2 and TLR4 in peripheral blood monocytes in the observation group and control group were higher than those in the healthy group（P＜0.05），and they were higher in the observation group than in the control group（P＜0.05）.ConclusionThe levels of TLR2 and TLR4 in peripheral blood monocytes of children with RV enteritis complicated with myocardial damageare significantly higher than those of children in control group and healthy group，which can be used as a diagnostic index for early diagnosis of RV enteritis complicated with myocardial damage. Related Articles | Metrics

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High risk factors of neonatal respiratory distress syndrome in twin pregnancy YIN Xue, YI Haiying, GAN Bin, YANG Shujie, YIN Nana, YAO Huajun, ZHANG Hai′e 2022, 14 (6):  508-512.  Abstract ( 90 )   PDF (821KB) ( 15 )   Save ObjectiveTo investigate the incidence and risk factors of neonatal respiratory distress syndrome（NRDS） in twin pregnancy.MethodsThe clinical data of 222 pairs（444 cases） of live twin newborns hospitalized in the Department of Neonatology of Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from January 2017 to December 2021 were analyzed retrospectively，including 51 pairs of twins（102 cases）(both with NRDS)(group A)，39 pairs of twins（78 cases）(one with NRDS)(group B ) and 132 pairs of twins（264 cases）(without NRDS)(group C).The general data of newborns and the incidence of NRDS in the three groups were compared.Results(1) Univariate analysis showed that there were significant differences in gestational age and birth weight between group A/group B and group C(P<0.001). There was a statistically significant difference in prenatal corticosteroid use between group A/group B and group C(P<0.001). The ratio of Apgar score ≤7 in 1 min between group A/group B and group C was statistically significant(P<0.001).（2）Taking group C as the control group，the gestational age，birth weight and prenatal corticosteroids use were included to construct a multivariate logistic regression equation. The results showed that twins with small gestational age，1 min Apgar score ≤7 and no prenatal use of corticosteroids were more likely to suffer from NRDS.Conclusion Twins with small gestational age，no prenatal use of corticosteroids and 1 min Apgar score ≤7 are more likely to develop NRDS. There are differences in NRDS between twins，which is related to gestational age and 1 min Apgar score ≤7.Therefore，prenatal use of corticosteroids should be standardized to prevent asphyxia;select appropriate delivery time and mode，to reduce the occurrence of NRDS.ConclusionTwins with small gestational age，no prenatal use of corticosteroids and 1 min Apgar score ≤ 7 are more likely to develop NRDS.There are differences in NRDS between twins，which is related to gestational age and 1 min Apgar score ≤7.Therefore，prenatal use of corticosteroids should be standardized to prevent asphyxia，select appropriate delivery time and mode，and reduce the occurrence of NRDS. Related Articles | Metrics

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Comparison of clinical features and cytokines in infants and young children with the first wheezing caused by Mycoplasma pneumoniae and respiratory syncytial virus SHAN Yuxia, CHEN Haixia, ZHU Ziwei, CHI Lei, YU lu 2022, 14 (6):  512-516.  Abstract ( 95 )   PDF (828KB) ( 42 )   Save ObjectiveTo explore the clinical characteristics and the expression of interferon-γ（IF-γ，Th1 cytokine），interleukin-4 and interleukin-33（IL-4，IL-33，Th2 cytokine） of infants and young children with the first wheezing caused by Mycoplasma pneumoniae（MP） and respiratory syncytial virus（RSV）.MethodsTotally 82 cases and 68 cases with respectively confirmed MP and RSV infection causing first-time wheezing in infants and young children were collected from January 2019 to December 2020，and they were regarded as MP and RSV infection group，and 30 healthy infants and young children were selected as healthy control group. The clinical characteristics of the MP group and the RSV group were compared，and the IFN-γ，IL-4 and IL-33 contents of the peripheral blood of the three groups were detected . The ratios of IFN-γ/IL-4 and IFN-γ/IL-33 were calculated and compared.ResultsCompared with the RSV infection group，MP infection group had an older age，shorter wheezing course，fewer proportion of fever,higher level of WBC count,lower proportion of lymphocyte，higher total IgE level，lower CRP level，with a statistical difference between the two groups（P＜0.05）.Compared with the health control group，IFN-γ levels decreased，IL-4 and IL-33 levels increased，and IFN-γ/IL-4 and IFN-γ/IL-33 ratios decreased in MP and RSV infection groups，and the differences were statistically significant（P＜0.05）.Compared with the MP infection group，the RSV infection group had lower IFN-γ levels，higher IL-4 and IL-33 levels，and lower ratio of IFN-γ/IL-4 and IFN-γ/IL-33, with a statistical difference between the two groups（P＜0.05）.ConclusionCytokines IFN-γ，IL-4，IL-33 and Th1/Th2 imbalance with Th2 advantaged response may be involved in the first wheezing caused by MP and RSV infection in infants and young children. Related Articles | Metrics

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Study on predictive efficacy of the thromboelastogram on abnormal coagulation in critically ill neonates LIAN Xiyuan, GUO Huiping, HE Kangkang, YANG Mei. 2022, 14 (6):  517-521.  Abstract ( 57 )   PDF (847KB) ( 24 )   Save ObjectiveTo investigate the relationship between thromboelastogram and severity of disease in critically ill neonates and its predictive efficacy for coagulation dysfunction.MethodsA total of 160 critically ill neonates admitted to our hospital from June 2021 to December 2022 were selected as the study subjects.According to the neonatal critical case Score(NCIS),there were 86 cases in the critical group(NCIS score:70 to 90 points) and 74 cases in the extremely critical group(NCIS score:<70 points).The parameters of thrombolysis diagram［reaction time(R time),coagulation time(K time),α Angle,maximum thrombolysis force(MA),fibroactivity index(EPL) and decreasing rate of coagulation amplitude(LY30)］ were compared between the two groups.Pearson correlation analysis was used to analyze the relationship between thrombolysis diagram parameters and NCIS score to analyze the abnormal coagulation function.The area under receiver operating characteristic curve(AUC) was used to evaluate the predictive efficacy of thromboelastogram parameters for coagulation abnormalities.ResultsR time and K time were shorter in critical group than in critical group,α Angle,MA,EPL and LY30 were higher than in critical group,the differences were statistically significant(P<0.05).According to Pearson correlation analysis,NCIS score was positively correlated with R time and K time(P<0.05),but negatively correlated with αAngle,MA,EPL and LY30(P<0.05).Among 160 critically ill neonates,84(52.50%) had coagulation dysfunction.Multivariate Logistic regression analysis showed that R time and LY30 were independent predictors of coagulation dysfunction in critically ill neonates(P<0.05).According to ROC curve analysis,the AUC of R time combined with LY30 predicting the occurrence of coagulation dysfunction in critically ill newborns was 0.912.ConclusionThrombolysis diagram is closely related to the severity of the condition of critically ill neonates,R time combined with LY30 has good efficacy in predicting coagulation dysfunction,which is worthy of clinical application. Related Articles | Metrics

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Changes of serum Irisin and Von will brand factor-cleaving protease in full-term asphyxiated newborns and their effects on neurological prognosis ZHOU Hong. 2022, 14 (6):  521-524.  Abstract ( 71 )   PDF (858KB) ( 34 )   Save ObjectiveTo investigate the changes of serum Irisin and Von will brand factor-cleaving protease（ADAMTS-13） levels in full-term asphyxiated newborns and their effects on the prognosis of neurological function.MethodsTotally 87 full-term asphyxia newborns treated in our hospital from August 2019 to February 2021 were selected as the asphyxia group（n=87）;87 healthy newborns were included in the same period as the control group（n=87）.The changes of serum Irisin and ADAMTS-13 levels in different groups were analyzed. All children were followed up to 3 months old to analyze the relationship between neurological development and serum Irisin and ADAMTS-13 in the two groups. Spearman was used to analyze the relationship between serum Irisin，ADAMTS-13 and NBNA score. The ROC curve was drawn to analyze the predictive efficacy  Related Articles | Metrics

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Comparison of the effects of two types of adenoidectomy on children with secretory otitis media complicating adenoid hypertrophy WANG Xin, LIU Zhijian, LIU Huiying, SUN Shuyang. 2022, 14 (6):  525-528.  Abstract ( 80 )   PDF (809KB) ( 88 )   Save ObjectiveTo investigate the efficacy of low temperature plasma adenoidectomy with that of electric aspiration adenoidectomy in the treatment of secretory otitis media in children with adenoid hypertrophy.MethodsFrom January 2021 to May 2022，70 children with secretory otitis media complicating adenoid hypertrophy were enrolled in our hospital.The randomized number table method was used to randomly divide them into two groups,with 35 in each. Group A(control group) received electric aspiration adenoidectomy + catheterization，while group B(observation group) received low temperature plasma adenoidectomy + catheterization）.Observe the treatment effect，hearing intensity before and after surgery，operation time，postoperative pain score,intra-operative bloodloss,incidence of adverse events and expression of serum inflammatory factors were observed.ResultsAfter treatment，the effective rate of group A was 71.4%，which was significantly lower than that of group B(97.1%) and the difference was statistically significant（P＜0.05）.The air conduction level and the bone conduction were significantly lower in the two groups after treatment，but the difference between the two groups was not statistically significant（P＞0.05）.The operation time，the pain score at 12h after operation and the intraoperative blood loss were significantly lower in group B than in group A，the difference being statistically significant（P＜0.05）.The incidence of adverse events in group A was 28.6%(10/35), significantly higher than that in group B(5.7%,2/35),and the difference was statistically significant（P＜0.05）.Serum IL-1β and TNF-α were significantly lower in group B than in group A at 1 month and 6 months after treatment（P＜0.05）.ConclusionLow-temperature plasma adenoidectomy combined with catheterization,compared with electric aspiration adenoidectomy, has a better effect，reducing the operation time，intraoperative blood loss and postoperative 12h pain score.The incidence of adverse events and the levels of serum IL-1β and TNF-α at 1 month and 6 months after treatment are reduced，but it has no particular effect on hearing improvement. Related Articles | Metrics

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Treatment forviral pneumonia in children based on Luomai-Xuanweifu theory ZHANG Xiuying, WANG Xuefeng, LIU Qing, YANG Mengfei. 2022, 14 (6):  529-531.  Abstract ( 77 )   PDF (774KB) ( 7 )   Save Viral pneumonia is an acute inflammation caused by a viral infection in lung parenchyma and(or) interstitial lung.Especially, in the 21st century,the viral pneumonia induced by new respiratory viruses, such as severe acute respiratory syndrome(SARS) coronavirus and new coronavirus(nCoV) has become a global public health problem facing humans.Most pathogens have no specific treatment.Traditional Chinese medicine has certain advantages and characteristics in preventing and treating childhood viral pneumonia because of its individualized syndrome differentiation. This article uses the Luomai-Xuanweifu theory as a guide to explore the pathogenesis and treatment of viral pneumonia in children. First, the origin of the Luomai-Xuanweifu theory is traced by mining the ancient and modern literature. Secondly, the interpretation of Luomai-Xuanweifu theory is made from the perspective of modern medicine.Based on the pathogenesis and pathological manifestations of viral pneumonia,it is proposed that obstruction of Luo and closure of Xuan is the key to the pathogenesis of viral pneumonia.Finally the treatment method of Tongluo Kaixuan is summarized, which is expected to provide clinical guidance. Related Articles | Metrics

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Analysis on rules of acupoint selection for children with autism spectrum disorder receiving acupuncture treatment based on complex network technique XING Chang, ZHANG Jinsheng, MA Yongqing. 2022, 14 (6):  532-538.  Abstract ( 97 )   PDF (973KB) ( 163 )   Save ObjectiveTo explore the core acupoints and compatibility rules of related acupoints in clinical acupuncture treatment for children with autism spectrum disorder(ASD) based on complex network technique.MethodsThe relevant articles of clinical trials on acupuncture treatment for children with autism spectrum disorder(ASD) were retrieved from CNKI, WanFang,VIP, CBM, PubMed and Web of Science published before April 2022.The database was established by using Microsoft Excel 2019.By using SPSS Modeler 18.0 software, the association rules of acupoints was analyzed, and then by using Gephi 0.9.2 software the complex network was analyzed and the complex network diagram was demonstrated.ResultsFinally, a total of 128 eligible articles containing 244 acupoint prescriptions and 154 acupoints were extracted.The total frequency of use of the 154 acupoints was 2 437.According to the frequency statistics and complex network k-core analysis,the core acupoints of clinical acupuncture treatment for ASD were mainly the acupoints selection of Jin's Three Needling therapy. Moreover, the association rules analysis also showed that the acupoints selection of Jin's Three Needling therapy had the highest correlation in the prescription of acupuncture for children with ASD. In addition to Jin's Three Needling therapy, according to Gephi analysis, acupoints such as Baihui(DU20), Zusanli(ST36), Neiguan(PC6), Sishencong(EX-HN1), Shenting(DU24), and Shenmen(HT7) had the higher value.These acupoints were also important acupoints in the treatment of children with ASD.ConclusionThe acupoints selected for acupuncture treatment for children with ASD are mainly distributed in the head, and local acupoints are mainly selected. Jin's Three Needling therapy is the most widely used, and clinical attention is paid to governing and regulating the mind. Related Articles | Metrics

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Treatment for children with Henoch-Schonlein purpura nephritis from "deficiency of kidney Yin, stagnated fire in the nest" ZHENG Shan, LUO Lei, WEN Zhongyu, CHANG Ke. 2022, 14 (6):  538-541.  Abstract ( 76 )   PDF (804KB) ( 359 )   Save This paper discusses the etiology, pathogenesis, course characteristics and clinical symptoms of Henoch-Schonlein purpura nephritis based on the theory of 'pathogen lodging in Shaoyin'. The deficiency of kidney yin is the primary condition of hidden pathogen storing in the body.The inducing factors were exposure to six excesses，diet irritation and contact with allergic substances．External evil is from the surface into the inside, gathering in the throat.It turns into heat after along period of time and becomes a latent fire. The latent fire consumes the fluid and blood and becomes stagnated. The stagnated fire is interconnected and becomes disease of the nest, and stays at kidney collaterals. Latent fire goes outside, and the conflict occurs between pathogenic qi and vital qi. The heat damages the blood collaterals, blood overflows to the skin, and blood seeps to urine, then skin ecchymosis or hematuria occurs.The latent fire is hidden and thepathogenic qi and vital qi are not in conflict, then there is no hematuria or skin ecchymosis. The latent and recurrent process of pathogenic qi is the basic feature of insidious pathogenic diseases.The treatment often depends on its stages, including acute stage and remission stage. In the acute stage, the treatment methods are clearing latent fire, activating blood circulation and dispelling blood stasis. In the remission stage, the treatment methods are nourishing Yin and blood and repairing kidney veins. Fumai decoction, Didang decoction and Liuwei Dihuang pill can be used flexibly in a comprehensive treatment for Henoch-Schonlein purpura nephritis. Eliminating the disease nest and removing the insidious pathogens can stop and reverse the persistent and refractory disease of nephritis. Related Articles | Metrics

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Clinical observation of self-made "Xiaoke paste" in treating children with acute cough of wind-cold to heat syndrome HUANG Jing, CHEN Anjing, LU Yunqian, WANG Yu. 2022, 14 (6):  542-545.  Abstract ( 77 )   PDF (791KB) ( 161 )   Save ObjectiveTo observe the curative effect of self-made "Xiaoke paste" in the treatment of acute cough in children with wind-cold to heat syndrome.MethodsA total of 114 children with acute cough who met the inclusion criteria were randomly divided into treatment group(n=56) and control group(n=58). On the basis of conventional treatment，"Xiaoke paste" or placebo were added respectively，and the course of treatment was 7 days. Before and after treatment，the main TCM syndromes and signs scores，the minor TCM syndrome scores，and the total scores of TCM syndromes and signs were observed，and the clinical efficacy and incidence of adverse events were evaluated.ResultsAfter treatment，the scores of main TCM syndromes and signs，the scores of secondary TCM syndromes，and the total scores of TCM syndromes and signs in the two groups were all lower than those before treatment,and the treatment group was lower than the control group,the difference being statistically significant（P＜0.05）.The total effective rates of the treatment group and the control group were 92.8%(52/56) and 77.6%(45/58)，respectively，and the treatment group was significantly higher than the control group（P＜0.05）.There were no serious adverse events in either group.Conclusion"Xiaoke paste" can significantly improve the symptoms of acute cough with wind-cold to heat syndrome in children，and the clinical control rate is significant. Related Articles | Metrics

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Meta-analysis of children idiopathic short stature treated by integrated traditional Chinese and western medicine CONG Ming, DONG Dan, LYU Keyao, WANG Xuefeng, WNAG Guanghai. 2022, 14 (6):  545-552.  Abstract ( 137 )   PDF (3823KB) ( 23 )   Save ObjectiveTo systematically evaluate the clinical effect of combining traditional Chinese with western medicine and western medicine alone in treating children's idiopathic short stature（ISS），and to provide evidence-based medical reference for clinical treatment of children's idiopathic short stature.MethodsResearchers retrieved CNKI，WANFANG，VIP，CBM and PubMed，the retrieval time for each database was from its establishment to May 31，2022.The literature which eventually met eligibility criteria was analyzed by RevMan 5.4.1 software provided by Cochrane website.ResultsA total of 18 randomized controlled clinical trials were included in the study，sample size being 1 572 cases，among which 782 were in experimental group and 790 cases in  Related Articles | Metrics