Abstract: Objective To investigate the distribution of positive pathogenic bacteria in blood culture of neonates with sepsis and the value of sCD14-ST in early diagnosis.Methods Detect the blood culture pathogens of septic children in the neonatal ward of the first hospital of Longyan City，Fujian Province from January 2019 to December 2019，and analyze the levels of sCD14-ST，WBC，N% and serum CRP. Results The basic diseases of neonatal sepsis mainly included neonatal respiratory distress syndrome，accounting for 36.5%（19/52）.The pathogenic bacteria of term infants were mainly Escherichia coli and Staphylococcus aureus.Escherichia coli was the main pathogenic bacteria in premature infants. There was significant difference in sCD14-ST and serum CRP among the three groups（P＜0.05），but there was no significant difference in WBC，N% or PCT（P＞0.05）.There was significant difference in sCD14-ST between Gram-positive bacteria group and Gram-negative bacteria group（P＜0.01）.The areas under the curve for sCD14-ST and CRP were （ROCAUC=0.89,0.70），respectively. The diagnostic sensitivity and specificity of sCD14-ST were 88.5% and 86.7%. Conclusion Escherichia coli is the main pathogenic bacteria in neonatal sepsis.sCD14-ST has guiding value in early diagnosis.

Key words: Sepsis, Blood culture, sCD14-ST, Infant,newborn