Abstract:
Objective
To investigate the diagnostic value of determination of prothrombin time(PT) and C-reactive protein(CRP) in early childhood bacterial sepsis.
Methods
From March 2015 to May 2016, 30 children with bacterial sepsis and 30 children with common fever were treated in Hunan Children's Hospital, and they were assigned to study group and control group respectively. The prothrombin time and C-reactive protein(CRP) concentration in peripheral blood of the two groups were detected and recorded 24 hours after onset, and the accuracy of diagnosis was compared.
Results
The prothrombin time and C-reactive protein in the study group were significantly higher than those in the control group(P<0.05). The combined determination of prothrombin time and C-reactive protein was more specific than either of the two indexes. The false-positive rate and specificity were decreased.
Conclusion
The combined detection of prothrombin time and C-reactive protein can improve the diagnosis specificity of early bacterial septicemia in children and reduce the false positive rate of diagnosis. It is helpful in the early diagnosis of the disease.

Key words: Sepsis, Prothrombin time, C-reactive protein, Diagnosis, Children