Abstract: Objective To analyze the clinical characteristics of neonatal pseudomonas putida infection in our hospital,and provide reference for clinical diagnosis and treatment.Methods The clinical data of 29 neonatal pseudomonas putida infection treated in the hospital from February 2017 to February 2023 were analyzed retrospectively.Results The average gestational age of 29 neonates was (33±4)weeks,including 9 full-term babies and 20 premature babies;the average birth weight was (2 187±1 053)g,including 13 very low birth weight infants.All patients were treated with broad-spectrum antibacterial drugs,and were mostly given long-term parenteral nutrition before infection.Twelve patients had mechanical ventilation,11 cases had a surgical history of gastrointestinal disease,and 11 cases had peripheral insertion of central catheters(PICC).The main clinical manifestations were fever,dyspnea,poor response and abdominal distension.Manifestations appeared (22±6)days after birth.Five cases(17.2%) infants were with low white blood cell (WBC) counts,11 cases(37.9%) had thrombocytopenia(<100×109/L),26 cases(89.7%) had elevated C-reactive protein (CRP),with the average CRP level being (64.7±62.5) mg/L;the average PCT level was increased,being (4.4±4.1)μg/L;interleukin-6 (IL-6) was significantly increased in 9 cases,of which interleukin of 4 cases was ＞5 μg/L;hemoglobin level was (101.0±22.8)g/L,and globulin level was (15.6±3.8)g/L,levels being low.Blood culture，sputum culture and bacterial culture of CSF were the identification methods,the bacteria were more sensitive to cefepime,amikacin and levofloxacin,and the prognosis was mostly good after anti-infection treatment.A total of 27 cases (93.1%) were cured and 2 cases (6.9%) died .Conclusion The neonates infected with pseudomonas putida are mainly blood-borne infections,and premature infants,low birth weight infants and immunocompromised infants are susceptible.Invasive operation increases the risk of infection with this bacteria,and cephalosporins,aminoglycosides and quinolones are preferred as antibiotics.Sensitive antibiotics should be selected for treatment,which has a better prognosis.

Key words:

Sepsis, Pseudomonas putida, Amikacin, Neonates, Premature infant