Abstract:
Objective: To investigate the effects of the combined use of tanshinone ⅡA and naloxone on nerve injury in neonates with hypoxic-ischemic encephalopathy.
Methods: Sixty-six neonates with hypoxic-ischemic encephalopathy were equally randomized into tanshinone ⅡA plus naloxone,naloxone,and control groups.The conventional symptomatic treatment was given to the neonates in the three groups;the neonates in tanshinone ⅡA plus naloxone and naloxone groups were respectively given combined treatment for 10~14 days or naloxone treatment alone for 5~7 days. Neurological scores were assessed at birth and at the end of treatment, and the serum levels of neuron specific enolase were determined.
Results: Compared with before treatment,the neurological scores were increased to different degrees,while the serum neuron specific enolase levels were decreased after treatment;those changes were the most obvious in the combined treatment group(P<0.01).After treatment,the neurological scores were the highest,while the serum neuron specific enolase levels were the lowest in the combined treatment group compared with the other two groups(P<0.01).
Conclusion: The use of tanshinone ⅡA plus naloxone in the treatment of hypoxic-ischemic encephalopathy can significantly attenuate nerve injury.

Key words: Hypoxic-ischemic encephalopathy, Tanshinone ⅡA, Naloxone, Neonates