Abstract:

ObjectiveTo detect the common wheezing diseases in infants and serum levels of vitamin A in healthy children of the same age, to investigate the correlation between vitamin A levels and common wheezing diseases, and to provide new ideas for early identification and prevention of bronchial asthma.MethodsTotally 100 cases of infants with wheezing diseases admitted to our hospital from March 2017 to March 2018 were selected as the observation group and 100 healthy infants who were matched with the observation group in age, gender and time of treatment were selected as control group. Serum vitamin A of all subjects was measured to compare the difference in serum vitamin A between infants with wheezing disease and normal infants. The infants with vitamin A deficiency were treated with vitamin A preparation on the basis of basic treatment. The drug treatment was stopped after the vitamin A reached normal level. The patients were followed up for 3 months, 6 months and 12 months to compare the level of serum vitamin A and the number of wheezing episodes. The difference in the number of wheezing episodes between normal serum vitamin A group and vitamin A deficiency group was compared.ResultsThere were 68 cases of vitamin A deficiency and 32 cases of normal serum vitamin A in the observation group, 21 cases of vitamin A deficiency and 79 cases of normal serum vitamin A in the controls. The difference between the two groups was statistically significant(P<0.05).The levels of vitamin A of infants at 0～1 year and >1～3 years old in the observation group were significantly lower than those at the same age in the control group, and the difference was statistically significant(P<0.05). At 3,6 and 12 months of follow-up, there was a negative correlation between the level of serum vitamin A and the number of wheezing episodes in children with wheezing diseases(P<0.05).At 3,6 and 12 months of follow-up, there was significant difference in the number of wheezing episodes between normal serum vitamin A group and vitamin A deficiency group in the wheezing disease children(P<0.05).ConclusionThe level of serum vitamin A in infants with wheezing diseases is lower than that in healthy infants. There is a negative correlation between the level of serum vitamin A and the number of wheezing episodes. The lower the level of serum vitamin A, the higher number the wheezing episodes occur in infants with wheezing disease. After the correction of serum vitamin A in infants with wheezing diseases complicated with vitamin A deficiency, the number of wheezing episodes decreases.

Key words:

Wheezing, Vitamin A, Infants