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25 December 2019, Volume 11 Issue 6 Previous Issue    Next Issue

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Research on the medication rule of famous veteran doctor of TCM-Zhao Kun-in prescriptions containing Aconiti lateralis radix praeparata based on data mining WANG Yanhui, SONG Guihua, ZHAO Kun 2019, 11 (6):  461-464.  doi: 10.3969/j.issn.1674-3865.2019.06.001 Abstract ( 170 )   Save Objective:To explore the medication rule of famous veteran doctor of TCM-Zhao Kun-in prescription containing Aconiti lateralis radix praeparata.Methods:Based on the establishment of prescription database, the method of association rules was used to analyze the following items in the prescriptions containing Aconiti laterlis radix praeparata, including the frequency of single drug, frequency of drug combination, the association rules and the core drug combinations.Results:The prescriptions containing Aconiti lateralis radix praeparata were commonly used for treating asthma, cough and common cold. The drugs with highest frequency were Aconiti lateralis radix praeparata, Ephedrae herba, Farfarae flos, Houttuynia cordata thunb, Armeniacae semen amarum, Phragmitis rhizoma, Gypsum fibrosum and so on. The drug combinations with highest frequency were 'Aconiti lateralis radix praeparata and Ephedrae herba', 'Aconiti lateralis radix praeparata and Paeoniae radix rubra', and 'Aconiti lateralis radix praeparata and Pseudostellariae radix'. The drug association rules with the confidence being more than 0.9 were 'Aconiti lateralis radix praeparata→Ephedrae herba','Aconiti lateralis radix praeparata→Farfarae flos', 'Paeoniae radix rubra→Aconiti lateralis radix praeparata', and'Paeoniae radix alba→Ephedrae herba, Aconiti lateralis radix praeparata', and so on. The core drug combinations of association rules for treating asthma, cough and common cold had some similarities to Mahuang Fuzi Xixin decoction and Xiaoqinglong decoction.Conclusion:The prescriptions containing Aconiti lateralis radix praeparata developed by Pro. Zhao are widely used in pediatric pulmonary disease syndrome. The prescription medication is more concentrated, and the combination method is clear. Related Articles | Metrics

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Professor Li Naigeng's experience in treating infantile fever YUAN Yang, CHEN Guangming, LI Zhiwu, MU Guiping, YANG Lixia, Li Naigeng 2019, 11 (6):  465-467.  doi: 10.3969/j.issn.1674-3865.2019.06.002 Abstract ( 153 )   Save Fever is one of the most common symptoms in pediatrics, and its etiology is diverse. It is necessary to examine the causes of fever in clinical practice. Professor Li Naigeng believes that the treatment for children's fever should not only treat the symptoms of fever, but also treat children's fever according to the cause of fever. First of all, we should distinguish exogenous fever from internal injury fever. When treating exogenous fever, we should follow the principle of "medication based on eliminating pathogenic factors", treat the disease as early as possible, control the situation, and dispel pathogenic factors. In the treatment of fever due to internal injury, attention should be paid to strengthening the body and protecting Yang and nourishing yin. The treatment should focus on taking care of children's spleen and stomach, and make good use of external treatment.  Related Articles | Metrics

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Analysis of professor Zhao Kun's experience in treating bronchopneumonia in children YU Suping, ZHAO Kun, ZHANG Yan, SONG Guihua, GUAN Zhiwei, GUO Yanrong, BAI Yufan 2019, 11 (6):  468-470.  doi: 10.3969/j.issn.1674-3865.2019.06.003 Abstract ( 142 )   Save Bronchopneumonia is a common respiratory disease in children. It belongs to the category of pneumonia and wheezing in traditional Chinese medicine. Professor Zhao Kun has rich clinical experience in treating this disease. In the early stage of treatment, the treatment should focus on superficial symptoms, so promoting lung qi and relieving cough and asthma are the main points; in the middle stage, the treatment should focus on phlegm and toxin, which is to clear lung, remove toxin and phlegm and relieve lung and asthma; in the recovery stage, the treatment should focus on deficiency, which is to nourish yin and clear heat, supplement qi and invigorate spleen, and warm yang and disperse coldness; in the long term, the treatment should focus on blood stasis, to activate blood circulation and remove blood stasis. Professor Zhao Kun, the tutor, also has unique opinions on the prescriptions for different stages of the disease, which has achieved good clinical efficacy. Related Articles | Metrics

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Professor Li Yingcun's experience in using Dunhuang Children's Cold Dysentery Prescription in treating children's dysentery of deficiency-cold type YE Hong, LI Yingcun, LI Xinhao, LI Junke, JI Wenda, WU Xinfeng 2019, 11 (6):  471-474.  doi: 10.3969/j.issn.1674-3865.2019.06.004 Abstract ( 135 )   Save Professor Li Yingcun is a well-known expert in the study of Chinese medical literature in Dunhuang， the leader of Dunhuang medical discipline in the 12th Five-Year Plan of the State Administration of Traditional Chinese Medicine， and the vice-president of the Basic Medical College of Gansu University of Traditional Chinese Medicine. He has been engaged in clinical work of traditional Chinese medicine for a long time. He is good at excavating ancient books， devoting himself to research， thinking deeply and exploring the root causes of the development of modern diseases ,and he has rich experience. Especially， Prof. Li is good at using Dunhuang ancient medical prescriptions to treat medical diseases flexibly， and has achieved remarkable effects. It is my honor to be the successor of Professor Li Yingcun's academic experience， and has benefited a lot. Now I will introduce Prof. Li's experience in using Child Cold Dysentery Prescription in the treatment of infantile diarrhea of deficiency-cold type. Related Articles | Metrics

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Analysis of Prof. Shi Zhenggang's experience in treating pediatric urticaria LIU Yao, LIU Chi, SHI Zhenggang 2019, 11 (6):  474-476.  doi: 10.3969/j.issn.1674-3865.2019.06.005 Abstract ( 145 )   Save Urticaria is also known as rash and sputum in traditional Chinese medicine， and based on different clinical syndromes, the treatment of expelling wind， to clear heat and cold is used. Prof. Shi has been working on pediatric clinical work for over 30 years. He proposes that the "wind" plays a vital role in the pathogenesis of urticaria in children，and the reserved external "wind" and the inside "Fuxie" are the cause of the disease. The external "wind" and the "evil spirits" violating the body of "Fuxie" is the common pathogenesis of the disease. The "wind" should be expelled to control the disease in the acute attack period， and in the remission period the body should be strengthened and regulated so that the disease is no longer relapsed when there is "wind" again. Related Articles | Metrics

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Experience of GE Meifei in treating recurrent respiratory tract infection in children with the combination of internal with external treatment QU Feng, GE Meifei 2019, 11 (6):  477-479.  doi: 10.3969/j.issn.1674-3865.2019.06.006 Abstract ( 156 )   Save This paper introduces Professor Ge's experience in preventing and treating recurrent respiratory tract infection in children. Professor Ge thinks that the physiological characteristics of children are the intrinsic factors of their being prone to repeated respiratory tract infection, the incomplete cleaning of chronic lesions is the main cause of its "being easy to recur", and the bad diet and living habits are the inducing factors. She treats the disease by stages and syndrome differentiation according to the principle of " symptomatic treatment in acute condition and radical treatment in chronic case " ，and the treatment features the combination of internal with external treatment, emphasing both the prevention and the treatment. It has been proved that the patient compliance is higher and the clinical effect is more significant in this combined treatment. Related Articles | Metrics

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Treatment for pulmonary diseases in children based on liver  WANG Shiyuan, SONG Guihua 2019, 11 (6):  480-482.  doi: 10.3969/j.issn.1674-3865.2019.06.007 Abstract ( 128 )   Save Pulmonary diseases in children are common and frequently-occurring diseases in pediatrics, most of which are treated based on lung. However, because of its complex etiology, it is by no means possible to treat the lung alone. The function of liver is closely related to the physiology and pathology of lung; therefore, the liver is closely related to pulmonary diseases in children. In view of the close relationship between liver and lung, it is common to treat liver in clinic. Children's lung diseases, such as cough, pneumonia, asthma and so on, can be treated based on the liver, and the differential treatment includes regulating the liver, calming the liver, soothing the liver, clearing the liver, nourishing the liver and softening the liver, in order to achieve the effect of regulating liver and benefiting lung, and reducing qi and relieving asthma. Related Articles | Metrics

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Clinical effects of Kechuanping granules in adjuvant therapy for bronchial asthma attack in children and its effect on the level of leukotriene CUI Heqing, SHANG Lili. 2019, 11 (6):  483-487.  Abstract ( 106 )   Save ObjectiveTo observe the clinical efficacy of Kechuanping granules in children with cold asthma in the attack of bronchial asthma, and its effect on serum LTB4 and urine LTE4 levels. MethodsSixty children with cold asthma in the attack of bronchial asthma, who were admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from December 1, 2017 to December 31, 2018, were selected as research subjects. They were randomly divided into 31 cases in observation group and 29 cases in control group. The control group was treated with western medicine routinely, and the observation group was treated with Kechuanping granules orally on the basis of the treatment for control group. After 7 days, the changes in the clinical efficacy and TCM syndrome total score of the two groups were observed; the serum LTB4 and urine LTE4 levels were measured by enzyme-linked immunosorbent assay before and after treatment.ResultsThe total clinical effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the total score of TCM syndromes in both groups was significantly lower than that before treatment, and the difference was statistically significant (P<0.05); the total score of TCM syndromes in the observation group was significantly lower than that in the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the levels of serum LTB4 and urine LTE4 in the two groups were significantly lower than those before treatment, and the difference was statistically significant (P<0.05). After treatment, serum LTB4 and urine LTE4 levels in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05).ConclusionKechuanping granules can significantly improve the TCM syndrome scores of children with cold asthma during bronchial asthma attack and improve clinical efficacy. Kechuanping granules can reduce serum LTB4 and urinary LTE4 levels in children with bronchial asthma, and its mechanism may be related to the reduction of LTs levels in children. Related Articles | Metrics

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Effect of Huxiang compatibility of five meridians combined with acupuncture on language ability of children with autism spectrum disorder HE Jinhua, WANG Paoqiu, QIN Rong, YUAN Liping, LIU Zhixiong, LIU Hongwen. 2019, 11 (6):  487-491.  Abstract ( 111 )   Save ObjectiveTo observe the effect of Huxiang compatibility of five meridians combined with acupuncture on language ability of children with autism spectrum disorder.MethodsFrom April 2016 to March 2019,69 children with autism spectrum disorder were treated in our rehabilitation center. According to whether the children and their families received acupuncture treatment and cooperated with us, they were divided into observation group(n=40) and control group(n=29).The control group received early comprehensive rehabilitation intervention(behavior correction, interpersonal relationship development, sensory integration, etc.), and the observation group was treated with Huxiang compatibility of five meridians combined with acupuncture on the basis of the treatment for the control group. Before and after treatment, Gesell development scale and children's Autism Behavior Scale(ABC) were used for testing, and S-S language development retardation was evaluated in the two groups. The clinical treatment efficiency of the two groups was compared.ResultsThere was no significant difference in language score Gesell, ABC or S-S language development between the two groups before treatment(P>0.05).After 3 and 6 months of rehabilitation intervention, the scores of Gesell language and S-S language development of the two groups were higher than those before treatment, while that of ABC was lower(P<0.05).The results of repeated measurement variance analysis showed that time effect, grouping effect and interaction effect of Gesell scale score, ABC scale score and S-S language development assessment score had statistical significance(P<0.05),indicating that the Gesell language occurrence score and S-S language development assessment score of the two groups were generally on the rise, while the ABC language disorder behavior score was on the decline, and the observation time point was related to the difference in Gesell, ABC and S-S scores. Six months after treatment, the Gesell scale scores and the clinical efficiency S-S language level in the treatment group were significantly higher than those in the control group（P<0.05）.ConclusionEarly intervention with Huxiang compatibility of five meridians combined with acupuncture for children with autism spectrum disorder can improve autism behavior and language ability. Related Articles | Metrics

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Progress in the application of bedside ultrasound in the follow-up of umbilical vein catheterization in very-low-birth-weight infants LIANG Zhenhua, LIU Guiliang, LI Liuqing, HUANG Hanwu. 2019, 11 (6):  492-496.  Abstract ( 102 )   Save Umbilical vein catheterization has been widely used in premature infants with very low birth weight; however, while establishing a "life channel" for premature infants, it may also bring about various catheter-related complications, and even lead to accidental death of premature infants. The occurrence of complications is closely related to the inaccurate localization of catheter tip and the displacement of catheter tip, and there is a lack of feasible methods for effective follow-up and maintenance of catheters. In recent years, with the introduction of bedside B-ultrasound for severe cases, bedside ultrasound has a good application value and prospect in the localization and follow-up of umbilical vein catheters in premature infants. Related Articles | Metrics

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Development of family-centered hospice care for children in China ZHANG Min 2019, 11 (6):  496-498.  Abstract ( 119 )   Save This paper discusses the 10-year development of hospice care for children in China, summaries the main activities in the family-centered hospice care, and analyzes the problems in its development. It proposes that the mode of informationalized multidisciplinary cooperation is the future direction of development in family-centered hospice care for children. Related Articles | Metrics

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Clinical value of laboratory test indicators in children with Henoch-Schonlein purpura ZHENG Lijuan, YU Jing, LI Xiaoqin , WANG Xianghui. 2019, 11 (6):  499-502.  Abstract ( 141 )   Save ObjectiveTo investigate the changes in immune function, lymphocyte subsets, IgE, platelet, D-dimer and urinary microalbumin in children with Henoch-Schonlein purpura and their clinical value.MethodsEighty children with Henoch-Schonlein purpura who were hospitalized in our hospital from June 2016 to June 2018 were enrolled. Among them, there were 40 patients with gastrointestinal symptoms as the first symptoms, and 40 patients with skin purpura as the first symptom. Another 40 children with acute gastroenteritis who were hospitalized during the same period were included in the study. The IgG, IgA, IgM, C3, C4, IgE, CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, platelet, D-dimer, and urinary microalbumin were compared between the three groups. ResultsThere were no significant differences in IgG, IgM, C3, C4 or platelet among the three groups (P>0.05). IgA, D-dimer, CD8+, CD19+ and urinary microalbumin were higher in the two groups of children with Henoch-Schonlein purpura than those in the acute gastroenteritis group, while CD3+, CD4+, CD4+/CD8+ were lower, the difference being statistically significant (P<0.05); there was no significant difference between the two groups of children with Henoch-Schonlein purpura (P>0.05). IgE was higher in children with Henoch-Schonlein purpura (skin purpura) than in children with Henoch-Schonlein purpura(gastrointestinal symptoms as the first symptoms) and those with acute gastroenteritis (P<0.05).There was no significant difference in IgE between children with Henoch-Schonlein purpura (gastrointestinal symptoms as the first symptom) and those with acute gastroenteritis(P>0.05).ConclusionThe clinical detection of IgA, lymphocyte subsets, D-dimer and urinary microalbumin is beneficial to the early diagnosis of children with Henoch-Schonlein purpura with gastrointestinal symptoms as the first symptoms. Related Articles | Metrics

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Therapeutic effect of oral muscle training combined with scalp acupuncture on dysarthria in children with spastic cerebral palsy HUANG Yuzhu, LI Xiaojie, ZHOU Li, ZHU Qiong, WANG Ting. 2019, 11 (6):  502-505.  Abstract ( 119 )   Save ObjectiveTo explore the clinical efficacy of oral muscle training combined with scalp acupuncture in the treatment of dysarthria in children with spastic cerebral palsy.MethodsSixty-six children with spastic cerebral palsy admitted to the Third Affiliated Hospital of Jiamusi University from June 2018 to June 2019 were randomly divided into experimental group and control group, 33 cases in each group. Both groups were treated for 6 months. The control group was trained in oral muscles. The experimental group received oral muscle training combined with scalp acupuncture treatment. The S-S language development retardation scale and the simple oral motor function scale were used to evaluate the language function and mouth movement of the two groups before and after treatment.ResultsAfter 6 months of treatment, the speech developmental quotient and understanding development quotient of the two groups were significantly higher than those before treatment, and the improvement level of the experimental group was significantly higher than that of the control group (P<0.05). The level of function of the mandible, lip, tongue and the whole mouth was significantly higher than that before treatment, and the improvement level of the experimental group was significantly higher than that of the control group (P<0.05).ConclusionOral muscle training and scalp acupuncture treatment for dysarthria in children with spastic cerebral palsy can effectively improve children's language function and improve oral motor function, and has significant clinical efficacy. Related Articles | Metrics

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Clinical observation of ultrasonic bulk resin in restoration of primary molar defect after root canal therapy XIANG Shanshan, CONG Fan 2019, 11 (6):  506-509.  Abstract ( 152 )   Save ObjectiveTo observe the clinical effect of ultrasonic bulk resin in restoration of primary molar defect after root canal therapy.MethodsTotally 78 children(126 primary molars) were included in the study, and they were randomly divided into two groups according to their visit to the hospital: 40 children(64 molars) in observation group and 38 children(62 molars) in control group. In observation group, the children were treated with SonicFill ultrasonic resin after root canal therapy, while the children in control group received Filtek Z350 resin after root canal therapy. The operation time, satisfaction after surgery, and the integrity, edge fitness and staining at 6 and 12 months after treatment were compared between the groups.ResultsThe operation time of experimental group was lower than that of control group, there was significant difference between two groups（P<0.05）.There was no significant difference between the two groups in postoperative satisfaction degree（P>0.05）. There was no significant difference between the two groups in integrity, edge fitness or staining after a follow-up of 6 months and 12 months（P>0.05）.ConclusionUltrasonic bulk resin in restoration of primary molar defect after root canal therapy can get superior clinical effect in a short time, and the operation time is shortened. It provides a better choice for resin filling in the tooth therapy for children. Related Articles | Metrics

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Clinical analysis of immunoglobulin and complement changes in children infected with EB virus GAO Jian, LI Fen. 2019, 11 (6):  509-511.  Abstract ( 147 )   Save ObjectiveTo analyze the changes of immunoglobulin and complement in children infected with EB virus. MethodsFrom January 1, 2017 to June 1, 2019, 100 children with EBV infection were treated in Shenyang Children's Hospital, and they were selected as the study subjects (the observation group), and 100 healthy children were selected as the control group at the same time. The complement level and serum immunoglobulin level of children in the two groups were detected by scatter turbidimetry, and the levels of C4, C3, IgE, IgA, IgM, IgG, CD56+, CD19+, CD4+, CD3+ were compared. ResultsThere was no significant difference in IgA between the observation group and the control group(P>0.05); C4, C3, IgE, IgM and IgG in the observation group were significantly higher than those in the control group(P<0.05). CD56+, CD19+ and CD3+ in the observation group were significantly higher than those in the control group, while CD4+ was significantly lower than that in the control group(P<0.05).ConclusionEpstein-Barr virus infection is closely related to immunoglobulin in children, and is significantly related to the decrease of CD4+. Related Articles | Metrics

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Analysis of clinical features of pertussis syndrome in infants HAN Fei, WU Chunxue, XU Hanyun. 2019, 11 (6):  512-515.  Abstract ( 135 )   Save ObjectiveTo investigate the clinical features of pertussis syndrome in infants, and to provide evidence for the diagnosis and treatment of the disease. MethodsA total of 68 infants with pertussis syndrome aged under 3 years old treated in the Emergency Ward of Jiangxi Children's Hospital from December 2017 to December 2018 were chosen as the research subjects. Among them, 32 cases were ≤6 months, 36 cases were >6 months; 50 cases were mild cases, and 18 cases were severe cases. Clinical data were compared among the groups. ResultsThe peak incidence was in winter and spring. All patients were admitted to hospital with cough as the chief complaint. In the group of infants under 6 months old, the number of cases of facial flushing, cyanosis after cough, chicken-like echo and severe cases, and white blood cell count in routine blood testing were higher than those in the group of infants over 6 months old; the cases whose spastic cough disappeared in one week were fewer than the group of infants over 6 months, and the hospitalization time was longer; the differences were statistically significant（P<0.05). The severe group was significantly younger than the mild group (P<0.01). The incidence of cyanosis after cough, the incidence of gastroesophageal reflux, the incidence of mixed virus infection, the hospitalization time and the routine white blood cell count in the severe group were significantly higher than those in the mild group; the differences were statistically significant (P<0.05). The hospitalization time of 68 children was 3 to 26 days, and the average hospitalization time was 9.02 days. After anti-infective, aerosol inhalation and supportive treatment, 36 patients (52.9%) were cured and discharged from hospitals, 30 patients (44.1%) had clinical symptoms improved, and 2 patients (2.9%) were further treated in PICU due to exacerbation.ConclusionPertussis syndrome is more common in infants and young children, paroxysmal spastic cough is a common manifestation, and the clinical manifestations in children under 6 months who have pertussis syndrome are more typical; the cases combined with gastroesophageal reflux, mixed infection, and marked increase in white blood cell count need to be alert to the possibility of developing into serious cases. Related Articles | Metrics

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Effect of propranolol combined with pingyangmycin sclerotherapy for infants with hemangioma and the risk factors analysis of tumor location and tumor area XIAO Yong, XIA Renpeng, ZOU Chanjuan, MA Tidong, ZHAO Fan, LI Bixiang. 2019, 11 (6):  516-520.  Abstract ( 142 )   Save ObjectiveTo compare the curative effect of surgical treatment with that of oral propranolol combined with pingyangmycin sclerotherapy in 3-month old infants with hemangioma, and to analyze the influencing factors related to tumor location and tumor area.MethodsForty hemangioma infants treated from April 2018 to October 2018 in our hospital were selected, including 20 patients receiving surgery and 20 receiving medication(oral propranolol+pingyangmycin sclerotherapy). The clinical efficacy and adverse reactions were retrospectively analyzed. Various risk factors potentially affecting tumor location and tumor area, such as child birth weight, pregnancy history, age, progesterone use history, vitamins excess, premature, placental abnormalities, and hypertension during pregnancy, were analyzed by multivariate logistic regression analysis to obtain independent risk factors.Results(1)There was no significant difference in the total effective rate between the two groups(P>0.05). (2)The number of adverse reactions in massive bleeding(>100 mL) and high fever(>38 ℃) in medication group was lower than that in surgery group, and the difference was statistically significant(P<0.05). (3)Analysis of risk factors of tumor location: child birth weight≤2 500 g and progesterone use history were independent risk factors for hemangiomas mainly in head and neck. Hemangioma incidence in head and neck was 13.698 times and 18.744 times that of tumor occuring in limbs and other parts, respectively. (4)Analysis of risk factors of tumor area: multiple pregnancy history was an independent risk factor for hemangioma area > 6 cm2. Its incidence was 17.896 times that of tumor area ≤6 cm2.ConclusionOral propranolol combined with pingyangmycin sclerotherapy is effective with few adverse reactions in treatment of 3-month old infants with hemangioma, which is worthy of clinical application. Moreover, it is essential to screen mothers' records of taking medication during pregnancy. Pregnant women taking progesterone with gestational age <37 weeks and several pregnancies should be given timely intervention treatment to avoid the occurrence and development of infant hemangiomas. Related Articles | Metrics

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Relationship between serum level of vitamin A and common wheezing diseases in infants LIU Chang, XU Hao, FAN Yuwen 2019, 11 (6):  521-524.  Abstract ( 105 )   Save ObjectiveTo detect the common wheezing diseases in infants and serum levels of vitamin A in healthy children of the same age, to investigate the correlation between vitamin A levels and common wheezing diseases, and to provide new ideas for early identification and prevention of bronchial asthma.MethodsTotally 100 cases of infants with wheezing diseases admitted to our hospital from March 2017 to March 2018 were selected as the observation group and 100 healthy infants who were matched with the observation group in age, gender and time of treatment were selected as control group. Serum vitamin A of all subjects was measured to compare the difference in serum vitamin A between infants with wheezing disease and normal infants. The infants with vitamin A deficiency were treated with vitamin A preparation on the basis of basic treatment. The drug treatment was stopped after the vitamin A reached normal level. The patients were followed up for 3 months, 6 months and 12 months to compare the level of serum vitamin A and the number of wheezing episodes. The difference in the number of wheezing episodes between normal serum vitamin A group and vitamin A deficiency group was compared.ResultsThere were 68 cases of vitamin A deficiency and 32 cases of normal serum vitamin A in the observation group, 21 cases of vitamin A deficiency and 79 cases of normal serum vitamin A in the controls. The difference between the two groups was statistically significant(P<0.05).The levels of vitamin A of infants at 0～1 year and >1～3 years old in the observation group were significantly lower than those at the same age in the control group, and the difference was statistically significant(P<0.05). At 3,6 and 12 months of follow-up, there was a negative correlation between the level of serum vitamin A and the number of wheezing episodes in children with wheezing diseases(P<0.05).At 3,6 and 12 months of follow-up, there was significant difference in the number of wheezing episodes between normal serum vitamin A group and vitamin A deficiency group in the wheezing disease children(P<0.05).ConclusionThe level of serum vitamin A in infants with wheezing diseases is lower than that in healthy infants. There is a negative correlation between the level of serum vitamin A and the number of wheezing episodes. The lower the level of serum vitamin A, the higher number the wheezing episodes occur in infants with wheezing disease. After the correction of serum vitamin A in infants with wheezing diseases complicated with vitamin A deficiency, the number of wheezing episodes decreases. Related Articles | Metrics

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Therapeutic effect of Three-Character massage on children with upper respiratory tract infection complicated with febrile convulsions PENG Feng, CHEN Aiming 2019, 11 (6):  525-528.  Abstract ( 176 )   Save ObjectiveTo explore the clinical effect of Three-Character massage on children with upper respiratory tract infection complicated with febrile convulsion.MethodsTotally 102 children with upper respiratory tract infection complicated with febrile convulsion admitted to Xiangyang Traditional Chinese Medicine Hospital from March 2016 to December 2018 were randomly divided into observation group and control group, with 51 cases each. According to the principle of western medicine treatment, the two groups were given antipyretic and sedative treatment, timely oxygen and liquid supplement support treatment, and appropriate anti-infection treatment according to the situation. On this basis, the observation group was given Three-Character massage treatment, 5 days as a course. The number of children with a second convulsion, duration of the convulsions, time of complete fever regression, improvement of catarrh symptoms of upper respiratory tract infection (runny nose, nasal obstruction, cough) and clinical effect were observed.ResultsAfter treatment, the number of children with a second convulsion, the duration of the convulsions, the time of complete fever regression and the time of disappearance of catarrh symptoms of upper respiratory tract infection in the observation group were significantly shorter than those in the control group, and the difference was statistically significant (P<0.05); the total clinical effective rate of the observation group was 98.04%(50/51), significantly higher than 74.51%(38/51) in the control group, the difference being statistically significant(P<0.05).ConclusionThree-Character massage has obvious curative effect on children with upper respiratory tract infection combined with febrile convulsion. It can rapidly relieve fever, reduce the frequency of convulsion recurrence, shorten the duration of recurrent convulsion, and quickly improve catarrh symptoms of upper respiratory tract infection. Related Articles | Metrics

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Evaluation of pulmonary function in infants with wheezing and the effectiveness of drug intervention KONG Yali, LIAN Pengqiang, AN Ni, ZHENG Ping, ZENG Zhiyong. 2019, 11 (6):  528-533.  Abstract ( 103 )   Save ObjectiveTo explore the guiding role of pulmonary function assessment for drug intervention program in infants with wheezing.MethodsA total of 312 children with asthma less than or equal to 5 years old admitted to our hospital from April 2016 to March 2019 were enrolled. The children were randomly divided into observation group and control group, 156 cases in each group. During week 1-4, the children in observation group were given inhalation of glucocorticoid+beta 2 receptor agonist + oral montelukast sodium, while the children in control group were given montelukast sodium only. During week 5-8, the children in observation group were given inhalation of glucocorticoid + oral montelukast sodium, while the children in control group were given montelukast sodium only. During week 9-12, the children in observation group were given montelukast sodium only, while the control group was not given any drug intervention. The difference in asthma symptom score and the number of wheezing relapses among different groups were compared.ResultsIn the infants with positive asthma prediction index (API), moderate obstruction and positive diastolic test, the asthmatic symptoms were milder in the observation group after 8 and 12 weeks of treatment, while the asthmatic symptoms were milder in the severe obstructive patients after 4, 8 and 12 weeks of treatment(P<0.05), but there was no significant difference in the improvement of asthmatic symptoms of patients with negative API, mild obstruction and negative diastolic test between the two intervention schemes(P>0.05). The recurrence rate of wheezing within 12 weeks in positive API, moderate and severe obstruction and positive diastolic test patients was significantly lower in the observation group than in the control group(P<0.05), but there was no significant difference in the recurrence rate of negative API, mild obstruction and negative diastolic test patients between the two intervention programs(P>0.05).ConclusionFor infants with wheezing, API prediction, tidal analysis and bronchodilation test can be used to evaluate pulmonary function in the early stage of the disease, which is helpful for the scientific formulation of drug intervention programs. For children whose pulmonary function assessment suggests progress to asthma, the combination regimen of glucocorticoid, beta-2 receptor agonist and leukotriene receptor antagonist should be given as soon as possible, and the medication regimen should be adjusted according to the course and condition of the disease and family condition. Related Articles | Metrics

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Study on the rule of medication in traditional Chinese medicine treatment for tic disorder based on literature analysis HUANG Tingyue, WANG Xuefeng. 2019, 11 (6):  534-539.  Abstract ( 204 )   Save ObjectiveTo analyze the prescription rule and TCM treatment of traditional Chinese medicine in the treatment of children with tic disorder, and to provide evidence for clinical treatment.MethodsUsing the keyword search method, the clinical research literature on the treatment with Chinese medicine and integrated traditional Chinese and western medicine for children with tic disorder published from January 2009 to January 2019 in the Chinese Academic Journal Full-text Database(CNKI) and Chongqing Weipu Database was searched. Download and read the full text, standardize the drugs, prescriptions and terminology in the literature, and extract the relevant information such as the title, publication date, prescription and Chinese medicine, etc.. Excel software was used for frequency analysis and SPSS 20.0 software was used for cluster analysis.ResultsA total of 128 articles were selected in this literature study. A total of 131 prescriptions were collected, involving 160 kinds of drugs. The Chinese medicines with higher frequency of use were debark peony root, Chinese thorowax root, gambir plant nod, liquorice root, stiff silkworm, tall gastrodia tuber, and Indian bread. The efficacy of the drugs was classified and counted. The drugs for calming liver wind and reinforcing deficiency were the most widely used, followed by the drugs for relieving exterior syndrome and clearing heat. Cluster analysis revealed 8 pairs of commonly used drugs and 4 groups of medicines. The drug pairs were tall gastrodia tuber and gambir plant nod, grassleaf sweetflag rhizome and milkwort root, debark peony root and Zhigancao, bile arisaema and tabasheer, bone fossil of big mammals and oyster shell, and immature orange fruit and bamboo shavings. The medicine groups were: dried tangerine peel, pinellia tuber and Indian bread; habitat, turtle shell and earthworm; stiff silkworm, cicada slough and scorpion; prepared rehmannia root and common yam rhizome.ConclusionThe change of liver wind inside the body is the main pathgenesis of tic disorder, and sputum heat, Yin-deficiency and external wind are closely related to the development of tic disorder. The treatment is mainly through calming liver wind, assisted by nourishing Yin and blood and relieving wind and exterior syndrome.  Related Articles | Metrics

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Analysis of drug use for chronic cough in children based on traditional Chinese medicine inheritance assistant system ZHOU Peng, LI Shuai. 2019, 11 (6):  539-543.  Abstract ( 138 )   Save ObjectiveThrough the assistant platform of traditional Chinese medicine inheritance， this paper discussed and analyzed the prescriptions of traditional Chinese medicine for chronic cough in children in China KNOWN database， to find out the law of drug use.MethodsCollect prescriptions for chronic cough in children in KNOWN database， and analyze the law of drug combination in prescriptions with the help of traditional Chinese medicine inheritance assistant system.ResultsTotally 248 prescriptions were screened， involving 185 kinds of traditional Chinese medicines. Frequency and association rules of drug use in prescriptions were analyzed. Altogether 12 core drug combinations and 6 new prescriptions were found. In the TCM treatment for children with chronic cough, the commonly used drugs were apricot,Herba ephedrae, aster, dried orange peel, Rhizoma pinelliae, carthworm, cicada slough, peach seed and Carthamus tinctorious.ConclusionThrough data analysis, it is found that phlegm-resolving drugs， insect drugs and blood-activating drugs are the main drugs of traditional Chinese medicine in the treatment of children's chronic cough in KNOWN database. The results of this study have certain guiding significance and reference value for the prescription law in the treatment of children's chronic cough. Related Articles | Metrics

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Analysis of large dose of Rhizoma Atractylodis macrocephalae for functional constipation in children SONG Zhe, ZHANG Heng, ZHANG Baoqing. 2019, 11 (6):  544-546.  Abstract ( 161 )   Save With the change of living habits, children with functional constipation become more common in pediatric clinics. Prolonged and unhealed constipation is more likely to lead to a variety of complications, and has a great impact on the growth and development of children. So doctors and parents of children should pay attention to it. Traditional Chinese medicine has a significant effect in the treatment of functional constipation in children. The clinical use of high-dose Rhizoma Atractylodis macrocephalae for children with functional constipation has significant efficacy and high safety. Related Articles | Metrics

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Analysis of high risk factors for failure of newborn in hearing screening in Shenyang area WANG Fang, LI Hongbo, GUO Yin. Dadong 2019, 11 (6):  547-549.  Abstract ( 101 )   Save ObjectiveTo investigate the risk factors for the failure of newborn in hearing screening.MethodsA total of 1 262 neonates were tested for hearing by otoacoustic emissions(OAE) and automatic auditory brainstem response(AABR) from January 2014 to July 2018 in our hospital. All the data of the newborn and their mothers were analyzed retrospectively. The electronic medical record includes: neonatal gestational age, neonatal gender, mode of delivery, maternal age, neonatal bilirubin encephalopathy, neonatal asphyxia, hyperbilirubinemia, and premature rupture of membranes. Univariate and multivariate logistic regression analysis was used to explore the risk factors affecting hearing loss.ResultsIn the 1 262 cases, 64 cases(5.07%) failed in the hearing screening, of which 36 cases(56.25%) failed in both ears, 15 cases(23.44%) failed in the left ear and 13(20.31%) in the right ear. Univariate and further Logistics regression analysis showed that gestational age <32W, neonatal bilirubin encephalopathy, neonatal asphyxia, hyperbilirubinemia, and premature rupture of membranes were independent risk factors for neonatal in failure hearing screening(P<0.01).ConclusionGestational age <32W, neonatal bilirubin encephalopathy, neonatal asphyxia, hyperbilirubinemia and premature rupture of membranes are risk factors for neonatal hearing loss. Hearing screening measures should be adopted to make early detection and intervention in order to reduce the incidence of hearing loss in the newborn. Related Articles | Metrics

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Effect analysis of evidence-based nursing in rehabilitation nursing for children with cerebral palsy WU Yingying, SHANG Qing, ZHANG Qingmei. 2019, 11 (6):  550-553.  Abstract ( 135 )   Save ObjectiveTo study the effect of evidence-based nursing in rehabilitation nursing for children with cerebral palsy.MethodsA total of 106 children with cerebral palsy admitted to our hospital from April 2016 to March 2019 were selected as subjects. These children were divided into observation group(evidence-based nursing) and control group (conventional nursing)， each with 53 cases. After one month of intervention， the two groups were compared in self-care ability， motor function， mental development index， the time for relieving symptoms of cerebral palsy, length of hospital stay, satisfaction degree of parents and the clinical effect.ResultsAfter intervention, the observation group had higher self-care ability， motor function and mental development index than the control group (P<0.05); relief time of cerebral palsy symptom and hospitalization time were shorter (P<0.05); the satisfaction degree of family members was higher (P<0.05). The efficacy of observation group(98.11%,52/53) was higher than that of the control group (86.79%,46/53) (P<0.05).ConclusionEvidence-based nursing for children with cerebral palsy can improve self-care ability， motor function and mental development index， improve symptoms and shorten hospitalization time， and increase family satisfaction degree and nursing efficacy， so it is worth promoting. Related Articles | Metrics