Abstract:

ObjectiveTo investigate the changes in immune function, lymphocyte subsets, IgE, platelet, D-dimer and urinary microalbumin in children with Henoch-Schonlein purpura and their clinical value.MethodsEighty children with Henoch-Schonlein purpura who were hospitalized in our hospital from June 2016 to June 2018 were enrolled. Among them, there were 40 patients with gastrointestinal symptoms as the first symptoms, and 40 patients with skin purpura as the first symptom. Another 40 children with acute gastroenteritis who were hospitalized during the same period were included in the study. The IgG, IgA, IgM, C3, C4, IgE, CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, platelet, D-dimer, and urinary microalbumin were compared between the three groups. ResultsThere were no significant differences in IgG, IgM, C3, C4 or platelet among the three groups (P>0.05). IgA, D-dimer, CD8+, CD19+ and urinary microalbumin were higher in the two groups of children with Henoch-Schonlein purpura than those in the acute gastroenteritis group, while CD3+, CD4+, CD4+/CD8+ were lower, the difference being statistically significant (P<0.05); there was no significant difference between the two groups of children with Henoch-Schonlein purpura (P>0.05). IgE was higher in children with Henoch-Schonlein purpura (skin purpura) than in children with Henoch-Schonlein purpura(gastrointestinal symptoms as the first symptoms) and those with acute gastroenteritis (P<0.05).There was no significant difference in IgE between children with Henoch-Schonlein purpura (gastrointestinal symptoms as the first symptom) and those with acute gastroenteritis(P>0.05).ConclusionThe clinical detection of IgA, lymphocyte subsets, D-dimer and urinary microalbumin is beneficial to the early diagnosis of children with Henoch-Schonlein purpura with gastrointestinal symptoms as the first symptoms.

Key words:

Henoch-Schonlein purpura, Gastrointestinal symptoms, Skin purpura, Early diagnosis, Child