Abstract:

ObjectiveTo analyze the prescription rule and TCM treatment of traditional Chinese medicine in the treatment of children with tic disorder, and to provide evidence for clinical treatment.MethodsUsing the keyword search method, the clinical research literature on the treatment with Chinese medicine and integrated traditional Chinese and western medicine for children with tic disorder published from January 2009 to January 2019 in the Chinese Academic Journal Full-text Database(CNKI) and Chongqing Weipu Database was searched. Download and read the full text, standardize the drugs, prescriptions and terminology in the literature, and extract the relevant information such as the title, publication date, prescription and Chinese medicine, etc.. Excel software was used for frequency analysis and SPSS 20.0 software was used for cluster analysis.ResultsA total of 128 articles were selected in this literature study. A total of 131 prescriptions were collected, involving 160 kinds of drugs. The Chinese medicines with higher frequency of use were debark peony root, Chinese thorowax root, gambir plant nod, liquorice root, stiff silkworm, tall gastrodia tuber, and Indian bread. The efficacy of the drugs was classified and counted. The drugs for calming liver wind and reinforcing deficiency were the most widely used, followed by the drugs for relieving exterior syndrome and clearing heat. Cluster analysis revealed 8 pairs of commonly used drugs and 4 groups of medicines. The drug pairs were tall gastrodia tuber and gambir plant nod, grassleaf sweetflag rhizome and milkwort root, debark peony root and Zhigancao, bile arisaema and tabasheer, bone fossil of big mammals and oyster shell, and immature orange fruit and bamboo shavings. The medicine groups were: dried tangerine peel, pinellia tuber and Indian bread; habitat, turtle shell and earthworm; stiff silkworm, cicada slough and scorpion; prepared rehmannia root and common yam rhizome.ConclusionThe change of liver wind inside the body is the main pathgenesis of tic disorder, and sputum heat, Yin-deficiency and external wind are closely related to the development of tic disorder. The treatment is mainly through calming liver wind, assisted by nourishing Yin and blood and relieving wind and exterior syndrome. 

Key words:

Tic disorder, Traditional Chinese medicine treatment, Efficacy of traditional Chinese medicine, Cluster analysis, Children