Abstract:

ObjectiveTo compare the curative effect of surgical treatment with that of oral propranolol combined with pingyangmycin sclerotherapy in 3-month old infants with hemangioma, and to analyze the influencing factors related to tumor location and tumor area.MethodsForty hemangioma infants treated from April 2018 to October 2018 in our hospital were selected, including 20 patients receiving surgery and 20 receiving medication(oral propranolol+pingyangmycin sclerotherapy). The clinical efficacy and adverse reactions were retrospectively analyzed. Various risk factors potentially affecting tumor location and tumor area, such as child birth weight, pregnancy history, age, progesterone use history, vitamins excess, premature, placental abnormalities, and hypertension during pregnancy, were analyzed by multivariate logistic regression analysis to obtain independent risk factors.Results(1)There was no significant difference in the total effective rate between the two groups(P>0.05). (2)The number of adverse reactions in massive bleeding(>100 mL) and high fever(>38 ℃) in medication group was lower than that in surgery group, and the difference was statistically significant(P<0.05). (3)Analysis of risk factors of tumor location: child birth weight≤2 500 g and progesterone use history were independent risk factors for hemangiomas mainly in head and neck. Hemangioma incidence in head and neck was 13.698 times and 18.744 times that of tumor occuring in limbs and other parts, respectively. (4)Analysis of risk factors of tumor area: multiple pregnancy history was an independent risk factor for hemangioma area > 6 cm2. Its incidence was 17.896 times that of tumor area ≤6 cm2.ConclusionOral propranolol combined with pingyangmycin sclerotherapy is effective with few adverse reactions in treatment of 3-month old infants with hemangioma, which is worthy of clinical application. Moreover, it is essential to screen mothers' records of taking medication during pregnancy. Pregnant women taking progesterone with gestational age <37 weeks and several pregnancies should be given timely intervention treatment to avoid the occurrence and development of infant hemangiomas.

Key words:

Hemangioma is infants, Propranolol, Pingyangmycin, Children