常克教授治疗儿童咳嗽用药规律数据挖掘

doi:10.20274/j.cnki.issn.1674-3865.2025.03.015

Abstract

Abstract:

Objective To analyze the medication rules of Professor Chang Ke in the treatment of cough in children，and summarize his thoughts on the treatment for cough. Methods Collect the prescriptions of Professor Chang Ke for the treatment of cough in the outpatient department from November 1，2023 to November 1，2024，standardize the drug names in the prescriptions，establish a database on the ancient and modern medical record cloud platform，and use multiple analysis methods to analyze the collected data from multiple perspectives，in order to explore the medication rules of Professor Chang Ke in the treatment of cough. Results A total of 567 prescriptions involving 224 Chinese medicines were included. According to the analysis of the data from the cloud platform of ancient and modern medical records, it was concluded that the high?frequency drugs were Scutellaria baicalensis，Apricot kernel，Pinellia ternata，Belamcanda chinensis，Platycodon grandiflorus，etc. The drug properties were mainly cold，warm，slightly cold and flat，the flavors of the medicines were bitter，spicy，sweet and slightly bitter，and the meridians involved were mainly the lung，stomach and spleen meridians. The main types of drugs were antipyretic and detoxifying drugs，pharynx?benefiting drugs and wind?heat?dispelling drugs. Four groups of drugs were obtained by cluster analysis，and 6 core drugs were obtained by complex network analysis. Conclusion Professor Chang Ke treats cough mainly based on "restoring the dispersion and descent of lung qi". He is good at using Chinese medicines with the effect of removing heat and toxin, dispelling wind heat, resolving dampness and phlegm and benefiting throat.

Key words: Cough, Data mining, Chang ke, Medication rules, Child

CLC Number:

R725.6

Yali CUI, Ke CHANG. Data mining of medication rules of Professor Chang Ke in the treatment of cough in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 264-269.

Figures/Tables 12

Table 1

Table 2

Table 3

Fig. 1

Table 4

Fig. 2

Table 5

Fig. 3

Table 6

Fig. 4

Table 7

Fig. 5

References 13

[1]	田之魁, 王东军, 周宗慧, 等. 国内小儿咳嗽诊疗指南/共识质量评价[J]. 世界科学技术-中医药现代化, 2021, 23(9): 3401-3407.
[2]	中华中医药学会肺系病分会,中国民族医药学会肺病分会.急性气管-支气管炎中医诊疗指南[J].中国循证医学杂志,2021,21(12):1365-1372.
[3]	Irusen EM. Lung diseases——selected state of the art reviews[M]. London：InTech，2012.
[4]	中华医学会儿科学分会临床药理学组, 国家儿童健康与疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组, 等. 中国儿童咳嗽诊断与治疗临床实践指南(2021版)[J]. 中华儿科杂志, 2021, 59(9): 720-729.
[5]	钟赣生. 中药学[M]. 4版. 北京: 中国中医药出版社, 2016.
[6]	国家药典委员会. 中华人民共和国药典[M]. 北京: 中国医药科技出版社, 2020.
[7]	常克. 中医病证治验条辨[M]. 北京: 人民卫生出版社, 2009: 38-40.
[8]	马玲玲, 孙燕. 中药黄芩药理作用的研究进展[J]. 沈阳医学院学报, 2016, 18(2): 115-117.
[9]	杨国辉, 魏丽娟, 王德功, 等. 中药苦杏仁的药理研究进展[J]. 中兽医学杂志, 2017(4): 75-76.
[10]	赵玉升, 胡杰, 吴佳姝, 等. 苦杏仁炮制方法及药理作用研究进展[J]. 中医药导报, 2021, 27(3): 175-180.
[11]	李哲, 玄静, 赵振华, 等. 半夏化学成分及其药理活性研究进展[J]. 辽宁中医药大学学报, 2021, 23(11): 154-158.
[12]	李国信, 姜鸿, 邸子真. 射干抗炎药效物质基础研究[J]. 药物评价研究, 2010, 33(5): 384-387.
[13]	赖东兰, 许华, 江美容. 叶天士《幼科要略》学术思想及其在儿科的临床应用[J]. 环球中医药, 2018, 11(7): 1063-1065.

序号	药物	频次	频率（%）
1	黄芩	329	58.02
2	苦杏仁	320	56.44
3	半夏	308	54.32
4	射干	292	51.50
5	桔梗	248	43.74
6	枇杷叶	239	42.15
7	桑白皮	229	40.39
8	麻黄	227	40.04
9	葶苈子	225	39.68
10	枳壳	219	38.62
11	陈皮	205	36.16
12	知母	201	35.45
13	款冬花	197	34.74
14	牛蒡子	194	34.22
15	麦冬	176	31.04
16	紫菀	165	29.10
17	紫苏子	152	26.81
18	甘草	152	26.81
19	蝉蜕	151	26.63

序号	功效	频次	频率（%）
1	清热解毒	1 158	12.07
2	利咽	791	8.24
3	疏散风热	655	6.82
4	燥湿化痰	554	5.77
5	降逆止呕	549	5.72
6	消痰	531	5.53
7	润肠通便	528	5.50
8	清热泻火	523	5.45
9	利水消肿	482	5.02
10	泻肺平喘	454	4.73

序号	四气	频次	频率（%）
1	寒	2 860	29.80
2	温	2 324	24.21
3	微寒	1 664	17.34
4	平	985	10.26
5	微温	873	9.10
6	凉	383	3.99
7	大寒	342	3.56
8	热	24	0.25
9	大热	1	0.01

序号	五味	频次	频率（%）
1	苦	5 009	52.19
2	辛	4 465	46.52
3	甘	3 150	32.82
4	微苦	725	7.55
5	咸	528	5.50
6	酸	520	5.42
7	淡	422	4.40
8	涩	174	1.81
9	微辛	74	0.77
10	微甘	7	0.07
11	微酸	2	0.02
12	微咸	0	0.00
13	微涩	0	0.00

序号	归经	频次	频率（%）
1	肺	7 306	76.12
2	胃	3 746	39.03
3	脾	1 916	19.96
4	肝	1 833	19.10
5	心	1 384	14.42
6	肾	1 269	13.22
7	大肠	954	9.94
8	膀胱	864	9.00
9	小肠	182	1.90
10	胆	131	1.36
11	心包	120	1.25
12	三焦	41	0.43

Data mining of medication rules of Professor Chang Ke in the treatment of cough in children

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 12

References 13

Related Articles 15

Recommended Articles

Metrics

Comments

组别	中药组成
1	蝉蜕、知母、麦冬
2	桔梗、枳壳、款冬花、紫菀、桑白皮、牛蒡子
3	甘草、紫苏子、葶苈子、前胡
4	陈皮、半夏、枇杷叶、射干、麻黄、苦杏仁、黄芩

序号	中药	中药	支持度	置信度	提升度	共现度	序号	中药	中药	支持度	置信度	提升度	共现度
1	射干	黄芩	0.42	0.81	1.40	237	13	紫菀	款冬花	0.28	0.97	2.79	160
2	桔梗	枳壳	0.38	0.87	2.25	215	14	旋覆花	黄芩	0.22	0.89	1.53	126
3	枳壳	桔梗	0.38	0.98	2.24	215	15	旋覆花	款冬花	0.22	0.88	2.53	125
4	枇杷叶	射干	0.37	0.89	1.73	212	16	旋覆花	半夏	0.22	0.87	1.59	124
5	枇杷叶	黄芩	0.34	0.82	1.41	195	17	旋覆花	射干	0.21	0.84	1.63	119
6	陈皮	半夏	0.34	0.95	1.74	194	18	瓜蒌皮	苦杏仁	0.21	0.84	1.49	118
7	麻黄	黄芩	0.34	0.84	1.45	191	19	旋覆花	陈皮	0.21	0.83	2.30	118
8	麻黄	射干	0.33	0.83	1.61	189	20	前胡	苦杏仁	0.20	0.82	1.45	116
9	牛蒡子	射干	0.31	0.91	1.77	176	21	瓜蒌皮	黄芩	0.20	0.82	1.41	116
10	陈皮	黄芩	0.31	0.84	1.45	173	22	瓜蒌皮	葶苈子	0.20	0.82	2.07	115
11	牛蒡子	黄芩	0.30	0.87	1.50	168	23	旋覆花	桑白皮	0.20	0.81	2.01	115
12	款冬花	紫菀	0.28	0.81	2.78	160	24	旋覆花	枇杷叶	0.20	0.81	1.92	115

[1]	. Clinical practice guidelines for integrative Chinese and western medicine in children with enuresis (2025) [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 185-198.
[2]	Yuanjun LU, Na CHEN, Yang YANG, Man CHENG, Duojian LI, Qiuyue LI, Zhu CHEN. Differentiated treatment for central precocious puberty based on the five viscera and the theory of "Tiangui" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 203-207.
[3]	Junchao LIU, Jiaojiao LIU, Hong XU. Retrospective analysis of liver⁃softening and spleen⁃strengthening therapy for children with precocious puberty of spleen⁃deficiency and liver⁃hyperactivity type [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 208-212.
[4]	Hongyan SHEN, Xuefeng WANG, Xinmin HAN, Bin YUAN, Siyuan HU, Xinmin LI, Lei XIONG, Ping HE, Ying ZHOU, Xuerong ZHANG, Jingwen MU. Clinical study on the treatment for children with acute tonsillitis (external wind⁃heat syndrome) with Bangbo Ruexiao granule [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 213-220.
[5]	Yihan XIE, Siying MEI, Xilian ZHANG. Research progress on evaluation indexes for clinical trials of infantile epileptic spasms syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 221-225.
[6]	Lingyan XUE, Jianying LI, Chunlan HE, Lingli ZHAO. Impact of short chain fatty acids and microbial community structure in feces on infants and young children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 226-230.
[7]	Lijuan ZHENG, Fumin XUE, Jing YU. Diagnostic value of GGT combined with DBIL for biliary atresia in different age groups of children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 231-236.
[8]	Haifei XIAO, Na WANG. Clinical observation of Xiaoer Dingchuan oral solution combined with western medicine treatment in the treatment of children with asthmatic bronchitis [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 242-245.
[9]	Huishuang CHEN, Qingling GUO, Lu DAI. Analysis of risk factors for retinopathy in very low birth weight infants [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 246-250.
[10]	Shengze ZHENG, Yanhong QIN, Feng ZHANG. Professor Qin Yanhong's clinical experience in differentiated treatment of functional constipation in children with the "multi⁃organ coordination" concept [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 251-255.
[11]	Zicheng ZHAO, Siyu WU, Pengfei YAN. Acupuncture combined with drug therapy in the treatment of childhood tic disorder based on the theory of Midnight⁃noon Ebb⁃flow [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 256-259.
[12]	Shiqing XU, Bin XIE, Xuefeng WANG. Professor Wang Xuefeng's experience in treating functional abdominal pain in children based on the theory of "treating middle Jiao through balancing" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 260-263.
[13]	Bo QI, Yuyan CHEN, Xiaoming WANG, Shen CHENG. Exploration of molecular mechanism of Tiaohe Zhidong prescription in the treatment of childhood tic disorders based on network pharmacology and molecular docking technology [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 270-276.
[14]	SHEN Hongyan, ZHANG Xiuying, TAN Chunying, SHANG Tao, MENG Bin, MU Jingwen, TIAN Zhifan, E Mingxin, WANG Xuefeng. A multi center clinical study on the adjuvant treatment with Fuxiong powder for children with Mycoplasma pneumoniae pneumonia [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(2): 93-98.
[15]	WU Pan, HUANG Tingyue, ZHANG Zhanling, WANG Xuefeng. Meta analysis and GRADE evaluation of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(2): 98-108.