基于数据挖掘探讨许华教授干预造血干细胞移植后患儿经验

doi:10.20274/j.cnki.issn.1674-3865.2026.02.013

Abstract

Abstract:

Objective To explore the patterns of traditional Chinese medicine (TCM) usage in Professor Xu Hua's interventions for pediatric patients post-hematopoietic stem cell transplantation (HSCT) through data mining techniques， summarize her clinical experience， and provide references for promoting the clinical application of TCM in the field of pediatric HSCT. Methods Prescriptions from pediatric patients treated by Professor Xu Hua at the First Affiliated Hospital of Guangzhou University of Chinese Medicine (outpatient or inpatient) between January 1， 2021， and December 12， 2024， were collected. Various data mining techniques， including frequency， dosage， and property analysis of TCM， association rule analysis， complex network construction， core TCM clustering analysis， and community analysis of compatible TCM， were employed to objectively present Professor Xu Hua's medication patterns. Results A total of 230 prescriptions involving 177 TCM herbs were included. The four natures of the herbs were predominantly warm， neutral， and slightly warm， while the five flavors were mainly sweet， pungent， and bitter. The meridians most frequently targeted were the spleen， lung， and stomach. The top five herb pairs with the highest co-occurrence frequency were Pinellia ternata(Fabanxia)-Poria(Fuling)， stir-fried Atractylodes macrocephala(Fuchaobaizhu)-Poria(Fuling)， stir-fried Atractylodes macrocephala(Fuchaobaizhu)-Pinellia ternata(Fabanxia)， tangerine peel(Chenpi)-stir-fried Atractylodes macrocephala(Fuchaobaizhu)， and tangerine peel(Chenpi)-Poria(Fuling). Herb pairs with 100% confidence included honey-fried Ephedra(Mimahuang)-bitter apricot kernel(Kuxingren)， Peucedanum praeruptorum(Qianhu)-bitter apricot kernel(Kuxingren)， dragon bone(Longgu)-oyster shell(Muli)， Ilex pubescens(Maudongqing)-honey-fried Ephedra(Mimahuang)， Ilex pubescens(Maudongqing)-bitter apricot kernel(Kuxingren)， and clam shell(Haqiao)-Pinellia ternata(Fabanxia). Six categories of core TCM prescriptions were identified， with Category 1(comprising Pseudostellaria heterophylla(Taizishen)， Poria(Fuling)， stir-fried Atractylodes macrocephala(Fuchaobaizhu)， Aucklandia lappa(Muxiang)， Pueraria lobata(Gegen)， Pogostemon cablin(Guanghuoxiang)， Pinellia ternata(Fabanxia)， tangerine peel(Chenpi)， charred hawthorn(Jiaoshanzha)， and licorice slice(Gancaopian) containing the most frequently used herbs. Conclusion Professor Xu Hua's interventions for pediatric patients post-HSCT primarily focus on strengthening the spleen's function， complemented by replenishing qi and nourishing yin， regulating the lung and kidney， resolving phlegm， and dispelling stasis. She prefers using herbs that serve both medicinal and dietary purposes， aiding in the generation and circulation of qi， blood， and body fluids in post-HSCT children， thereby improving the dysfunction or deficiency of multiple organs.

Key words: Hematopoietic stem cell transplantation, Traditional Chinese medicine, Famous physician experience, Medication patterns, Data mining, Child

CLC Number:

R272

Baoyi HUANG, Lichen YI, Yabin CHEN, Hua XU. Exploring Professor Xu Hua's experience in treating pediatric patients post-hematopoietic stem cell trans⁃plantation based on data mining[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(2): 157-167.

Figures/Tables 14

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References 31

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药物	频次	频率（%）	最小剂量（g）	平均剂量（g）	最大剂量（g）	药物	频次	频率（%）	最小剂量（g）	平均剂量（g）	最大剂量（g）
甘草片	168	73.04	4	6.05	12	苦杏仁	62	26.96	8	9.84	10
茯苓	155	67.39	10	15.26	50	炙甘草	61	26.52	5	9.13	10
麸炒白术	154	66.96	8	10.51	15	人参片	60	26.09	6	12.85	20
法半夏	147	63.91	6	8.96	10	酒萸肉	58	25.22	10	12.84	15
焦山楂	132	57.39	10	12.92	30	炒酸枣仁	51	22.17	10	17.16	20
陈皮	128	55.65	3	7.30	10	山药	49	21.30	15	18.88	30
太子参	102	44.35	10	15.69	30	五指毛桃	48	20.87	15	23.85	30
木香	91	39.57	4	6.53	10	姜厚朴	46	20.00	8	12.30	15
葛根	88	38.26	10	16.07	30	茯神	42	18.26	10	17.86	20
广藿香	87	37.83	5	8.56	10	款冬花	42	18.26	5	5.64	10
牡蛎	75	32.61	15	29.80	30	蜜麻黄	42	18.26	8	11.00	15
砂仁	72	31.30	3	6.47	10	麸炒枳实	37	16.09	8	11.19	15
苍术	67	29.13	8	11.01	15	甘草泡地龙	37	16.09	10	14.05	15
防风	63	27.39	10	19.44	30	前胡	34	14.78	8	9.71	10
黄芪	63	27.39	5	9.76	10	五味子	34	14.78	5	6.18	10

中药A	中药B	支持度（%）	A→B置信度（%）	B→A置信度（%）	提升度（%）	中药A	中药B	支持度（%）	A→B置信度（%）	B→A置信度（%）	提升度（%）
法半夏	茯苓	46.96	73.47	69.68	1.09	太子参	茯苓	30.00	67.65	44.52	1.00
麸炒白术	茯苓	45.22	67.53	67.10	1.00	太子参	麸炒白术	30.00	67.65	44.81	1.01
麸炒白术	法半夏	43.04	64.29	67.35	1.01	木香	麸炒白术	29.57	74.73	44.16	1.12
陈皮	麸炒白术	41.74	75.00	62.34	1.12	广藿香	焦山楂	29.13	77.01	50.76	1.34
陈皮	茯苓	41.30	74.22	61.29	1.10	葛根	焦山楂	28.70	75.00	50.00	1.31
焦山楂	茯苓	40.43	70.45	60.00	1.05	木香	茯苓	28.70	72.53	42.58	1.08
焦山楂	麸炒白术	40.00	69.70	59.74	1.04	焦山楂	木香	28.26	49.24	71.43	1.24
陈皮	焦山楂	38.26	68.75	66.67	1.20	木香	法半夏	27.83	70.33	43.54	1.10
陈皮	法半夏	38.26	68.75	59.86	1.08	葛根	茯苓	26.52	69.32	39.35	1.03
广藿香	葛根	37.39	98.85	97.73	2.58	广藿香	法半夏	26.09	68.97	40.82	1.08
葛根	木香	35.65	93.18	90.11	2.36	广藿香	茯苓	26.09	68.97	38.71	1.02
木香	广藿香	35.65	90.11	94.25	2.38	葛根	法半夏	26.09	68.18	40.82	1.07
太子参	焦山楂	31.74	71.57	55.30	1.25	太子参	陈皮	26.09	58.82	46.88	1.06
葛根	麸炒白术	30.87	80.68	46.10	1.20	太子参	木香	24.78	55.88	62.64	1.41
麸炒白术	广藿香	30.43	45.45	80.46	1.20	葛根	太子参	24.35	63.64	54.90	1.43

中药A	中药B	A→B置信度（%）	B→A置信度（%）	支持度（%）	提升度（%）	中药A	中药B	A→B置信度（%）	B→A置信度（%）	支持度（%）	提升度（%）
蜜麻黄	苦杏仁	100.00	67.74	18.26	3.71	甘草泡地龙	法半夏	91.89	23.13	14.78	1.44
前胡	苦杏仁	100.00	54.84	14.78	3.71	鸡内金	麸炒白术	91.30	13.64	9.13	1.36
龙骨	牡蛎	100.00	37.33	12.17	3.07	款冬花	苦杏仁	90.48	61.29	16.52	3.36
毛冬青	蜜麻黄	100.00	64.29	11.74	5.48	黄芩片	法半夏	89.66	17.69	11.30	1.40
毛冬青	苦杏仁	100.00	43.55	11.74	3.71	毛冬青	茯苓	88.89	15.48	10.43	1.32
蛤壳	法半夏	100.00	16.33	10.43	1.56	蜜麻黄	法半夏	88.10	25.17	16.09	1.38
广藿香	葛根	98.85	97.73	37.39	2.58	西洋参	牡蛎	86.96	26.67	8.70	2.67
毛冬青	法半夏	96.30	17.69	11.30	1.51	鸡内金	焦山楂	86.96	15.15	8.70	1.52
蛤壳	蜜麻黄	95.83	54.76	10.00	5.25	茯神	麸炒白术	85.71	23.38	15.65	1.28
蛤壳	苦杏仁	95.83	37.10	10.00	3.56	通草	法半夏	84.62	14.97	9.57	1.32
款冬花	法半夏	95.24	27.21	17.39	1.49	干石斛	牡蛎	84.00	28.00	9.13	2.58
广藿香	木香	94.25	90.11	35.65	2.38	苦杏仁	法半夏	83.87	35.37	22.61	1.31
前胡	蜜麻黄	94.12	76.19	13.91	5.15	麸炒枳实	麸炒白术	83.78	20.13	13.48	1.25
五味子	茯苓	94.12	20.65	13.91	1.40	甘草泡地龙	苦杏仁	83.78	50.00	13.48	3.11
葛根	木香	93.18	90.11	35.65	2.36	佛手	法半夏	83.33	13.61	8.70	1.30

参数	数值
节点个数	177
边个数	4 345
平均路径长度	1.724
平均节点度	49.096
网络直径	3
平均聚类系数	0.874

中药	度中心性	接近中心性	介数中心性	中药	度中心性	接近中心性	介数中心性
甘草片	0.88	0.89	933.96	苦杏仁	0.60	0.72	263.14
茯苓	0.85	0.87	740.97	炙甘草	0.64	0.73	285.72
麸炒白术	0.81	0.84	600.12	人参片	0.67	0.75	376.63
法半夏	0.82	0.85	712.04	酒萸肉	0.57	0.70	165.75
焦山楂	0.77	0.81	476.75	炒酸枣仁	0.59	0.71	158.42
陈皮	0.78	0.82	493.75	山药	0.44	0.64	75.14
太子参	0.69	0.76	277.93	五指毛桃	0.59	0.71	176.71
木香	0.65	0.74	218.20	姜厚朴	0.61	0.72	244.69
葛根	0.66	0.75	271.35	茯神	0.59	0.71	186.79
广藿香	0.63	0.73	205.34	蜜麻黄	0.42	0.63	80.34
牡蛎	0.64	0.73	233.56	款冬花	0.41	0.63	51.33
砂仁	0.66	0.75	294.80	麸炒枳实	0.46	0.65	92.09
苍术	0.68	0.76	306.32	甘草泡地龙	0.37	0.61	29.78
防风	0.61	0.72	211.48	五味子	0.40	0.62	58.67
黄芪	0.57	0.70	148.60	前胡	0.38	0.62	51.77

Exploring Professor Xu Hua's experience in treating pediatric patients post-hematopoietic stem cell trans⁃plantation based on data mining

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类别	中药组成
类别1	太子参、茯苓、麸炒白术、木香、葛根、广藿香、法半夏、陈皮、焦山楂、甘草片
类别2	牡蛎、砂仁、苍术、防风、黄芪、炙甘草、人参片、酒萸肉、炒酸枣仁、山药、五指毛桃、姜厚朴、茯神、建曲、龙骨、鸡内金、西洋参、白术
类别3	蜜麻黄、苦杏仁、前胡、款冬花、甘草泡地龙、毛冬青、蛤壳
类别4	麸炒枳实、地黄、乌梅、当归、土茯苓、蝉蜕
类别5	五味子、党参片、黄芩片、连翘、通草、北柴胡、佛手、麸炒枳壳、桂枝、鸡血藤、丹参、仙鹤草、熟地黄、浙贝母、薏苡仁、紫菀、紫苏梗
类别6	干鱼腥草、辛夷、炒苍耳子、白芷

社团	中药组成
社团1	干石斛、玄参、灯心草、酒女贞子、墨旱莲、麦冬、牡丹皮、炒麦芽、白芍、白茅根、炒稻芽、白薇、菝葜、麻黄、桑螵蛸、金樱子肉、糯稻根、牛膝、玉米须、浮小麦、醋龟甲、半枝莲、山慈菇、益智仁
社团2	淫羊藿、川芎、柏子仁、小茴香、化橘红、淡附片、赤芍、肉桂、火麻仁、百部、细辛、全蝎、桑白皮、白屈菜、盐菟丝子、酒苁蓉、射干、鹅管石、百合、青黛、炒僵蚕、地骨皮、重楼、干姜
社团3	泽泻、茵陈、莲子、猪苓、白花蛇舌草、芡实、车前子、醋延胡索、乌梅炭、广金钱草、诃子、黄连片、海金沙、山楂炭、龙胆、栀子、虎杖、佩兰、布渣叶、两面针、蚕砂、青皮、丁香
社团4	紫草、知母、徐长卿、芦根、地肤子、紫苏叶、荆芥穗、桔梗、苦参、岗梅、淡豆豉、白鲜皮、大青叶、青蒿、生石膏、鹅不食草
社团5	夏枯草、豆蔻、淡竹叶、净山楂、猫爪草、皂角刺、槟榔、滑石、当归尾、金银花、醋没药、醋乳香、枸杞子、决明子、青葙子、白扁豆、广东神曲

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