Abstract: Objective:To study the effect of Montelukast early intervention in wheezing of infants and in the prevention of asthma.
Methods:Between January 2013 and January 2015, 96 pediatric patients with wheezing were admitted to the Suzhou Municipal Hospital, and they were divided randomly into observation group and control group, each with 48 cases. The control group was treated with conventional therapy, while Montelukast sodium chewable tablets were given in observation group on the basis of treatment for control group. Observe the short-term effect and the clinical symptom score, and the incidence of asthma was followed up for 1.5 years.
Results:The total short-term rate was 93.75% in observation group and which was significantly higher than that of control group(79.17%), the difference being significant(P<0.05). After treatment, symptom scores for observation group significantly reduced, which were significantly lower than the control group, the difference being significant(P<0.05). Wheezing episodes for the observation group were significantly fewer than the control group, and the average duration was significantly shorter than the control group within 1 and a half years, the difference being significant(P<0.05). After 1 and a half years of follow-up, the incidence of asthma in the observation group was significantly lower than the control group, the difference being significant(P<0.05). No obvious adverse reaction occurred in both groups.
Conclusion：Montelukast early intervention can improve outcomes, alleviate clinical symptoms of acute exacerbation and reduce the incidence of asthma after wheezing.

Key words: Infant wheezing, Asthma, Montelakast sodium chewable tablets, Short-term effect