Abstract: Objective：To observe the effect of nursing intervention with 10% chloral hydrate taken orally in children requiring medical sedation.Methods：A total of 324 children admitted to Hunan Children's Hospital from January to December 2015 undergoing medical examination and requiring sedation were randomly divided into control group and observation group with 162 cases in each. The control group was sedated with 10% chloral hydrate,and routine nursing was performed. The observation group was intervened in addition to the routine nursing for the control group,such as the missionary health knowledge,psychological intervention and diet intervention. The duty nurse is responsible for guiding children to take oral chloral hydrate. Analyze and compare the sedative effect,sedation onset time,the incidence of adverse reactions and re-administration,and the satisfaction rate of parents between the two groups.Results：The effective rate of sedation in the observation group was 84.57% (137/162),which was significantly higher than that in the control group (58.02%,94/162) (P<0.01). The proportion of sedation onset time at 5 ~ 15 min in observation group was significantly higher than that in control group,while the proportion of the onset time of sedation >30 min was significantly lower than that in control group (P<0.01). The incidence of adverse reactions and the rate of re-administration in the observation group were significantly lower than those in the control group,with significant differences (P<0.01). The satisfaction rate of the family members in the observation group with sedation nursing intervention was significantly better than that in the control group,the difference being statistically significant (P<0.01).Conclusion：Effective nursing intervention can significantly improve the efficiency of oral administration of 10% chloral hydrate,reduce the onset time of sedation,and reduce adverse reactions. The satisfaction rate of family members is high,so it is worth applying widely clinically.

Key words: Medical examination, Nursing intervention, Oral 10% chloral hydrate, Child