Chinese Pediatrics of Integrated Traditional and Western Medicine

The protective effect of Schisandrin B(Sch B) on liver damage by Sodium valproateZHU Yan，WANG Junping. Liaoning Vocational College of Economic Technology，Shenyang 110122，China

2012, 4 (5): 405-406. doi: 10.3969/j.issn.16743865.2012.05.010

Abstract ( 291 )

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ObjectiveTo investigate the protective effect of Schisandrin B(Sch B) on liver damage by Sodium valproate in SD rats.
Methods30 SD rats had been administered respectively with Sodium valproate, Sch B + Sodium valproate and Normal Saline (NS) for 2 weeks, and then serum ALT and AST were determined.
ResultsThe level of serum ALT and AST in Sodium valproate group were significantly elevated in contrast with NS group (72.29±4.14, 67.26±2.38; 39.80±5.92,33.00±4.59 IU/L;P<0.05). But there were no significant difference between in Sch B + Sodium valproate group and in NS group (32.29±3.68,34.25±5.29;39.80±5.92, 33.00±4.59 IU/L;P>0.05).
ConclusionsSch B can reduce hepatic damages caused by Sodium valproate prominently.

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The multicenter study of bacterial pathogens and drug sensitivity in children with respiratory tract infection in Baoji city#br# WEI Shengyun,TANG Shubin,LI Wenjun,et al.Department of Pediatrics，Baoji Peole's Hospital，Baoji 721000,China

2012, 4 (5): 407-414. doi: 10.3969/j.issn.16743865.2012.05.011

Abstract ( 326 )

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ObjectiveTo summarize spectrum of bacterial pathogens and bacteriasensitive drugs of Baoji children with acute lower respiratory infections (ALRI).
MethodsFrom 201008 to 201107 in three domain District of Baoji City,the children from five hospital pediatric inpatient department with acute lower respiratory tract infection made,a retrospective pooled analysis in 6 234 cases about sputum culture identification and drug susceptibility test results.
Results(1)Of 6 234 cases of censorship specimens,1 827 cases were with positive result, the positive rate being 29.31%.The 1 882 coculture pathogens were divided into 23 kinds and the first 5 pathogens were Escherichia coli(20.72%),Klebsiella pneumoniae(17.48%),Streptococcus pneumoniae(16.84%),Pseudomonas aeruginosa(6.59%),Staphylococcus aureus(6.32%).(2)About 66.05% ALRI pathogens were G- bacteria,the vast majority of Enterobacteriaceae accounted for 86.56%,and Escherichia coli,Klebsiella pneumoniae highest in the first two accounted for 57.84%;G+cocci accounted for 29.05%;fungi ranked the seven.(3)Escherichia coli and Klebsiella pneumoniae were highly sensitive to Amoxicillin/Clavulanic acid,Ticarcillin/Clavulanic acid,Cefoxitin,Cefoperazone/Sulbactam,Piperacillin/Cilostazol Tazobactam,and could be used as an empiric antimicrobial treatment.All G- bacteria had no resistance to Imipenem.Pseudomonas aeruginosa in the region was highly sensitive to Ceftazidime.Resistance rate of streptococcus pneumoniae to penicillin was 70.57%,highly sensitive to the one to fourgeneration cephalosporins and amoxicillin/Clavulanic acid.Children in the region with lower respiratory tract sputum staphylococcus mainly had Staphylococcus aureus and coagulasenegative staphylococci(CNS),with oxacillin resistance rate being 92.69% and 82.69%;Streptococcus in the region leading to bacterial ALRI in children accounted for only 3.03% , highly sensitive to the antibiotics, so penicillin was still the preferred antibiotic.(4)Enterobacteriaceae as ALRI predominant pathogen in children had serious resistance,and opportunistic pathogen and opportunistic infection rates were likely to increase.
ConclusionsIn Baoji children ALRI bacterial pathogen spectrum has clear region and time features.Klebsiella pneumoniae,Escherichia coli,Pseudomonas aeruginosa,Streptococcus pneumoniae are 4 common pathogens in 0~14 yearold children in Baoji;pathogenic bacteria are mainly Gramnegative Enterobacteriaceae,and each age group has its own characteristics;antimicrobial susceptibility is obvious,and drug resistance problem is very grim.

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