ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2012, Vol. 4 ›› Issue (5): 405-406.doi: 10.3969/j.issn.16743865.2012.05.010

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The protective effect of Schisandrin B(Sch B) on liver damage by Sodium valproateZHU Yan,WANG Junping. Liaoning Vocational College of Economic Technology,Shenyang 110122,China

  

  • Published:2012-10-25 Online:2019-05-24

Abstract:
ObjectiveTo investigate the protective effect of Schisandrin B(Sch B) on liver damage by Sodium valproate in SD rats.
Methods30 SD rats had been administered respectively with Sodium valproate, Sch B + Sodium valproate and Normal Saline (NS) for 2 weeks, and then serum ALT and AST were determined.
ResultsThe level of serum ALT and AST in Sodium valproate group were significantly elevated in contrast with NS group (72.29±4.14, 67.26±2.38; 39.80±5.92,33.00±4.59 IU/L;P<0.05). But there were no significant difference between in Sch B + Sodium valproate group and in NS group (32.29±3.68,34.25±5.29;39.80±5.92, 33.00±4.59 IU/L;P>0.05).
ConclusionsSch B can reduce hepatic damages caused by Sodium valproate prominently.

Key words: liver damage;Sch B, Sodium valproate, rat, animal experiment