Abstract: Objective:To investigate the protective effect of Schisandrin B(Sch B) on liver damage by Sodium valproate in SD rats.Methods:30 SD rats had been administered respectively with Sodium valproate, Sch B + Sodium valproate and Normal Saline (NS) for 2 weeks, and then serum ALT and AST were determined.Results:The level of serum ALT and AST in Sodium valproate group were significantly elevated in contrast with NS group (72.29±4.14, 67.26±2.38; 39.80±5.92,33.00±4.59 IU/L;P<0.05). But there were no significant difference between in Sch B + Sodium valproate group and in NS group (32.29±3.68,34.25±5.29;39.80±5.92, 33.00±4.59 IU/L;P>0.05).Conclusions:Sch B can reduce hepatic damages caused by Sodium valproate prominently.

Key words: liver damage；Sch B, Sodium valproate, rat, animal experiment