ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2013, Vol. 5 ›› Issue (5): 387-389.doi: 10.3969/j.issn.16743865.2013.05.002

• 专栏 • 上一篇    下一篇

小儿止哮平喘颗粒对动物模型止咳化痰平喘作用的实验研究

彭征屏,冀晓华,邓云龙,安效先   

  1. 100091 北京,中国中医科学院西苑医院儿科
  • 出版日期:2013-10-25 发布日期:2019-06-18
  • 作者简介:彭征屏(1964-),女,副主任医师。研究方向:中西医结合儿科学。

Experimental study on antitussive expectorant and antiasthmatic effects of Zhixiao Pingchuan granule in animal models Peng Zhengping,Ji Xiaohua,Den Yunlong,et al. Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China

  • Online:2013-10-25 Published:2019-06-18

摘要:
目的观察小儿止哮平喘颗粒对动物模型的止咳化痰平喘作用。
方法以咳嗽、喘憋潜伏期,酚红排泌为指标,观察小儿止哮平喘颗粒对小鼠氨水引咳模型及气管段酚红法、豚鼠整体动物药物引喘模型的影响。
结果西药对照组、中浓度组、高浓度组引喘时间及跌倒时间与对照组比较差异均有统计学意义(P<0.05);对照组、低及中浓度组酚红浓度与高浓度组比较差异均有统计学意义(P<0.05)。
结论小儿止哮平喘颗粒对动物模型小鼠具有止咳化痰平喘作用。

关键词: 哮喘;咳嗽/治疗;止哮平喘颗粒/治疗应用;化痰;平喘;动物, 实验

Abstract:
ObjectiveTo investigate the antitussive,expectorant and antiasmatic effects of  Zhixiao Pingchuan granule(ZXPC) on animal models.
MethodsThe ammonia induced cough model in mice,phenol red secreting tests in mice and asthma induced by spraying method in guinea pig were adopted for observing the ZXPC effects of antitussion,expectorant and antiasthma.
ResultsZXPC can distinctly protract delitescence and increase musculus tracheal phenol red secretion.ZXPC could effectively proevent guinea pigs from asthma induced by histamine and acteylcholine mixture.
ConclusionZXPC has significant antitussive,expectorant and antiasmatic effects on animal models.

Key words: asthma;cough/therapy;Zhixiao Pingchuan granule/therapeutic use, phlegm, asthma, animal experimental